Results 71 to 80 of about 125,571 (334)

Optic Disc Imaging by Heidelberg Retinal Tomogram in Congenital Optic Disc Anomaly

Indian Journal of Ophthalmology, 2004
We evaluated two cases of congenital optic disc anomaly with the Heidelberg Retinal Tomograph (HRT) that could be mistaken for glaucomatous optic disc. One was an optic disc coloboma with a visual field defect and the other had an optic disc pit without ...
Kunjam Vallam, Sekhar G
doaj  

Radial optic neurotomy as a treatment for anterior ischemic optic neuropathy secondary to optic disc drusen

GMS Ophthalmology Cases, 2014
[english] Importance: Radial optic neurotomy (RON) was first described by Opremcak as a treatment for patients with central retinal vein occlusion (CRVO).
Pinxten, Isabel, Stalmans, Peter
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Prevalence of optic disc hemorrhages in rural central India. The Central Indian Eye and Medical Study. [PDF]

PLoS ONE, 2013
PURPOSE: To determine the frequency of optic disc hemorrhages in a rural Indian population. METHODS: The population-based Central Indian Eye and Medical Study included 4711 subjects. Mean age was 48.5±12.9 years (range: 30-100 years).
Jost B Jonas, Vinay Nangia, Anshu Khare, Maithili Kulkarni, Arshia Matin, Ajit Sinha, Krishna Bhojwani, Prabhat Nangia, Songhomitra Panda-Jonas   +8 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Membrane tissue on the optic disc may cause macular schisis associated with a glaucomatous optic disc without optic disc pits

Clinical Ophthalmology, 2013
Saori Takashina,1 Wataru Saito,1 Kousuke Noda,1 Maki Katai,2 Susumu Ishida11Department of Ophthalmology, Hokkaido University Graduate School of Medicine, 2Ophthalmology, Sapporo Teishin Hospital, Sapporo, JapanAbstract: This article reports a case of ...
Takashina S, Saito W, Noda K, Katai M, Ishida S   +4 more
doaj  

Multicolor imaging in optic disc swelling

Indian Journal of Ophthalmology, 2017
Differentiating optic disc edema (ODE) from pseudo optic disc edema (PODE) continues to pose a diagnostic dilemma. Current report highlights the role of multicolor imaging (MC) in differentiating ODE from PODE.
Nicey Roy Thomas, Prachi Subhedar Ghosh, Maitreyi Chowdhury, Kumar Saurabh, Rupak Roy   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source