Results 21 to 30 of about 424,514 (174)

Dissecting the angiogenic mechanism of pachychoroid polypoidal choroidal vasculopathy

iMeta, Volume 5, Issue 5, October 2026.
A prognosis‐oriented classification system was established to distinguish Pachy PCV from Non‐pachy PCV using a large multicenter dataset. Comparative plasma multi‐omics profiling of Pachy PCV, Non‐pachy PCV, and normal controls revealed unique upregulation of the fluid shear stress and atherosclerosis (FSS‐AS) and HIF‐1 signaling pathways in Pachy PCV.
Xinyu Zhao, Tiantian Cheng, Wenfei Zhang, Xingwang Gu, Qing Zhao, Yaning Chen, Lihui Meng, Jiaqi Zhang, Bintao Qiu, Lili Li, Shiyu Cheng, Zicheng Wang, Chuting Wang, Yuelin Wang, Zuyi Yang, Zhengming Shi, Ye Guo, Shengzhi Liu, Youxin Chen   +18 more
wiley   +1 more source

Insights into the modulation of age‐related macular degeneration: Molecular and systems‐level perspectives

Acta Ophthalmologica, Volume 104, Issue S293, Page S4-S35, October 2026.
ENGLISH SUMMARY In developed countries, age‐related macular degeneration (AMD) is the leading cause of visual impairment in the aging population. Understanding of its pathogenesis is limited and the number of patients is predicted to continue rising. AMD is classified into two main forms: dry and neovascular AMD (dAMD and nAMD, respectively).
Hanna Heloterä
wiley   +1 more source

The m.14484T>C MT‐ND6 Mutation Presenting with a Hereditary Spastic‐Paraparesis Phenotype

Movement Disorders Clinical Practice, EarlyView.
Gabriel Amorelli, Christelle Nilles, Gerald Pfeffer, Matthew Joel, Davide Martino   +4 more
wiley   +1 more source

ORBIT‐AMD: Ordinal Risk, Bilateral Imaging, and Trajectory Learning for Age‐Related Macular Degeneration in Multi‐Cohorts

Advanced Science, Volume 13, Issue 53, 24 September 2026.
Eligibility flow and real‐world AMD burden in the UKB retinal imaging cohort and TMUEH external‐validation cohort. Overview of the ORBIT‐AMD architecture, integrating retinal representation pretraining, bilateral eye‐graph modeling and concept bottleneck learning to support ordered risk, bilateral context, interpretable lesion concepts, longitudinal ...
Xuehao Cui, Dejia Wen, Patrick Yu‐Wai‐Man, Xiaorong Li   +3 more
wiley   +1 more source

A Review of Artificial Intelligence in Ophthalmology: Key Aspects, Challenges, and Future Directions

Eye &ENT Research, Volume 3, Issue 3, Page 125-154, September 2026.
ABSTRACT Artificial intelligence (AI) is increasingly reshaping ophthalmology because the specialty depends heavily on structured imaging, quantitative measurements, and repeatable diagnostic workflows. This review provides a clinically grounded and translationally oriented synthesis of AI in ophthalmology, covering methodological foundations ...
Partha Pratim Ray
wiley   +1 more source

Diagnosing Optic Disc Drusen in the Modern Imaging Era:A Practical Approach

, 2020
Optic disc drusen (ODD) are a well-recognised cause of an elevated optic disc appearance. When visible with ophthalmoscopy and fundus photography, ODD are readily identified. Yet, in more subtle cases of ODD, ancillary testing may be needed to render the
Sibony, P. A., Rothenbuehler, S. P., Hamann, S., Costello, F., the Optic Disc Drusen Studies Consortium, Optic Disc Drusen Studies Consortium, Costello, F, Sibony, PA, Rothenbuehler, SP, Hamann, S, F Costello, null the Optic Disc Drusen Studies Consortium, SP Rothenbuehler, PA Sibony, S Hamann   +13 more
core   +1 more source

Systematic Analysis of Plasma‐Derived Extracellular Vesicle‐Enriched Samples in Age‐Related Macular Degeneration Reveals Oxidative Stress Linked to Altered Lipid and Protein Profiles

Journal of Extracellular Biology, Volume 5, Issue 9, September 2026.
ABSTRACT Vision impairment caused by age‐related macular degeneration (AMD) is a global health priority. Retinal pathology is driven by ageing and exacerbated by genetic and environmental risk factors. Peripheral blood circulation is increasingly recognised as a contributor to disease initiation and progression, and a source of biomarkers to support ...
Marzena Kurzawa‐Akanbi, Jennifer Haggarty, Carina Hansohn, Mohamed T. Patel, Angela J. Cree, Peisi Teo, Milly Armstrong, Nathan Coles, Mark Platt, Helen Griffiths, Heather J. Cordell, Ahmad Khundakar, Pola Goldberg Oppenheimer, Phillip Whitfield, Andrew Lotery, Henning Urlaub, Sina Mozaffari‐Jovin, Majlinda Lako   +17 more
wiley   +1 more source

Revised Swedish visual field standards for a driver's licence: Threshold perimetry as a predictor of eligibility according to the current Swedish and current Norwegian suprathreshold standards

Acta Ophthalmologica, Volume 104, Issue 6, Page e709-e717, September 2026.
Abstract Purpose To explore whether threshold perimetry can predict fulfilment of the current Swedish and current Norwegian Esterman perimetry standards for Group 1 driver's licence, and differences in compliance between the former and current Swedish visual field standards.
Wid Saadi, Tomas Bro, Susanna Sagerfors
wiley   +1 more source

Idiopathic Intracranial Hypertension Is Characterized by a Distinct Proteomic Profile

Annals of Neurology, Volume 100, Issue 2, Page 255-267, August 2026.
Objectives The pathophysiology of idiopathic intracranial hypertension (IIH) is poorly understood and disease‐specific biomarkers are lacking. We aimed to shed light on IIH pathophysiology and identify disease‐specific biomarkers. Methods This prospective cross‐sectional cohort study included patients with new‐onset IIH and age‐, body mass index‐, and ...
Santosh D. Bhosale, Arkadiusz Nawrocki, Johanne J. Korsbæk, Nadja S. Hansen, Fabian Foettinger, Nik Krajnc, Mathias J. Norvig, Niclas L. Eriksen, Stefan Macher, Berthold Pemp, Connar S.J. Westgate, Christian B. Pedersen, Frantz R. Poulsen, Sune Munthe, Gabriel Bsteh, Martin R. Larsen, Rigmor H. Jensen, Dagmar Beier   +17 more
wiley   +1 more source

Choroidal Leakage during Daratumumab Therapy: A Desensitization‐Based Strategy for Treatment Continuation in Relapsed/Refractory Multiple Myeloma

eJHaem, Volume 7, Issue 4, August 2026.
ABSTRACT Background Daratumumab is widely used in relapsed/refractory multiple myeloma, but ocular adverse events are rare and not well‐characterized. Case Presentation A 68‐year‐old woman developed acute blurred vision during the second day of her first daratumumab infusion.
Metban Mastanzade, Zafer Cebeci, Kıvanç Koruk, Kerem Yiğit, Gül Beste Can, Sevgi Kalayoglu Beşışık   +5 more
wiley   +1 more source