Results 41 to 50 of about 2,091 (202)
Identification of Variants in Four Families With Inherited Eye Disorders by Whole Exome Sequencing
Molecular Genetics &Genomic Medicine, Volume 13, Issue 9, September 2025.Our study identified mutations in genes in families associated with different eye disorders. We also explored the effect of a novel variant identified in the ALMS1 gene by using patient‐specific cells. Finally, previously published data was compiled to establish the genotype–phenotype relation.
Afeefa Jarral +5 more
wiley +1 more source
Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis. [PDF]
, 2015 The degradation of phagosomes, derived from the ingestion of photoreceptor outer segment (POS) disk membranes, is a major role of the retinal pigment epithelium (RPE). Here, POS phagosomes were observed to associate with myosin-7a, and then kinesin-1, as
Diemer, Tanja +6 more
core +1 more source
Fast visible and extended nearinfrared multispectral fundus camera [PDF]
, 2019 We present a multispectral fundus camera that performs fast imaging of the ocular posterior pole in the visible and near-infrared (400 to 1300 nm) wavelengths through 15 spectral bands, using a flashlight source made of light-emitting diodes, and CMOS ...
Alterini, Tommaso +5 more
core +2 more sources
Aging Cell, Volume 24, Issue 9, September 2025.Cigarette exposure can induce the senescence of retinal pigment epithelium (RPE). The accumulation of naphthalene metabolites, namely 1,2‐dihydronaphthalene and 1,2‐naphthoquinone, in rats is a key factor in this process. In ARPE‐19 cells, the plasma of rats exposed to cigarette smoke can cause a significant increase in the level of reactive oxygen ...
Tingting Cui +16 more
wiley +1 more source
Acta Ophthalmologica, Volume 103, Issue 6, Page 615-621, September 2025.Abstract This review covers a seminal study of the relation between exposure to the glucagon‐like peptide 1 (GLP‐1) agonist semaglutide and incident non‐arteritic anterior ischaemic optic neuropathy (NAION) in a neuro‐ophthalmology clinic setting, subsequent studies in unselected populations, a meta‐analysis of clinical trials and pathophysiology ...
Abdullah Amini +2 more
wiley +1 more source
Contribution to the Optic Nerve [PDF]
, 2018 Optic nerve head drusen (ONHD) represent congenital anomaly, which is a form of calcium degeneration of optic nerve head axons. They are initially asymptomatic but may causes progressive optic neuropathy. They are presented as acellular, hyaline deposits
Radenković, Marija
core +1 more source
Acta Ophthalmologica, Volume 103, Issue 6, Page e385-e393, September 2025.Abstract Purpose This trial evaluated the noninferiority of a relaxed compared to a strict treat‐and‐extend treatment strategy in patients with neovascular Age‐related macular degeneration (AMD). Methods Multicenter, randomized, controlled, phase IV, non‐inferiority clinical trial.
Damian Jaggi +9 more
wiley +1 more source
Colorimetric analysis of eye fundus structures with multispectral retinography [PDF]
, 2021 The analysis of the eye fundus is critical to prevent retinal and choroidal diseases since most of them cause no symptoms at early stages. Treating them when the very first signs appear is crucial to avoid vision losses.
Alterini, Tommaso +3 more
core +2 more sources
Frequency of retinal findings after 8 years in the Bifocal Lenses in Nearsighted Kids (BLINK) Study
Ophthalmic and Physiological Optics, Volume 45, Issue 6, Page 1475-1484, September 2025.Abstract Purpose The purpose of the study is to report the frequency of retinal findings in myopic children and determine the association with the amount of myopia or axial length. Design The BLINK study was a myopia control, multi‐centre randomised clinical trial following myopic children with multifocal soft contact lenses. Participants Children aged
Krystal L. Schulle +44 more
wiley +1 more source
Circumscribed choroidal hemangioma: A case report and literature review [PDF]
, 2016 Choroidal hemangioma is a rare congenital ocular tumor that can present as either circumscribed or diffuse. Circumscribed choroidal hemangioma (CCH) typically manifests as a red-orange mass within the posterior pole and appears similar to other ocular ...
Berry, Morgan, Lucas, Linda J.H.
core +2 more sources