Results 41 to 50 of about 1,825 (178)

Dietary intake of whale oil–containing ω‐3 long‐chain polyunsaturated fatty acids attenuates choroidal neovascularization in mice

The FASEB Journal, Volume 39, Issue 4, 28 February 2025.
Whale oil suppresses choroidal neovascularization (CNV) in laser‐induced mice model of age‐related macular degeneration. Dietary intake of whale oil rich in ω‐3 long‐chain polyunsaturated fatty acids (LCPUFAs) reduced CNV. Whale oil feeding increases plasma ω‐3 LCPUFAs and decreases ω‐6 LCPUFAs, modulating intraocular cytokines and chemokine ...
Ryoji Yanai, Genta Yasunaga, Shunya Tsuji, Takeshi Honda, Arihiro Iwata, Eiji Miyagawa, Koji Yoshida, Mitsuhiro Kishimoto, Hiroki Sakai, Yoshihiro Fujise, Masataka Asagiri, Yoshinori Mitamura   +11 more
wiley   +1 more source

Congenital anomalies of the optic nerve in one family. [PDF]

, 1992
Journal ArticleWe present three cases of congenital optic disc anomalies in one family who underwent an extensive diagnostic workup to exclude any intracranial pathology.
Digre, Kathleen B., Mortenson, Steven
core  

Retinal thinning differentiates treatment effects in relapsing multiple sclerosis below the clinical threshold

Annals of Clinical and Translational Neurology, Volume 12, Issue 2, Page 345-354, February 2025.
Abstract Objective To investigate retinal layer thinning as a biomarker of disease‐modifying treatment (DMT) effects in relapsing multiple sclerosis (RMS). Methods From an ongoing prospective observational study, we included patients with RMS, who (i) had an optical coherence tomography (OCT) scan within 6 to 12 months after DMT start (rebaseline) and ≥
Gabriel Bsteh, Harald Hegen, Nik Krajnc, Fabian Föttinger, Patrick Altmann, Michael Auer, Klaus Berek, Barbara Kornek, Fritz Leutmezer, Stefan Macher, Tobias Monschein, Markus Ponleitner, Paulus Rommer, Christiane Schmied, Karin Zebenholzer, Gudrun Zulehner, Tobias Zrzavy, Florian Deisenhammer, Franziska Di Pauli, Berthold Pemp, Thomas Berger   +20 more
wiley   +1 more source

Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis. [PDF]

, 2015
The degradation of phagosomes, derived from the ingestion of photoreceptor outer segment (POS) disk membranes, is a major role of the retinal pigment epithelium (RPE). Here, POS phagosomes were observed to associate with myosin-7a, and then kinesin-1, as
Diemer, Tanja, Esteve-Rudd, Julian, Jiang, Mei, Lillo, Concepción, Lopes, Vanda S, Rump, Agrani, Williams, David S   +6 more
core   +1 more source

Study of macular and optic disk blood flow by angio‐OCT in Glucose‐6‐Phosphate Dehydrogenase (G6PD) deficient men and age‐related G6PD‐normal subjects [PDF]

, 2018
Purpose: The reported prevalence of Glucose‐6‐Phosphate Dehydrogenase (G6PD) deficiency in Sardina, Italy, ranges from 8% to 15%. Hemizygous males have totally deficient erythrocytes.
Boscia F, D'Amico-Ricci G, Giancipoli E, Marzano J, Pinna A, Porcu T   +5 more
core   +1 more source

Intravitreal Administration of Avacincaptad Pegol in a Nonhuman Primate Model of Dry Age‐Related Macular Degeneration

Pharmacology Research &Perspectives, Volume 13, Issue 1, February 2025.
Effect of intravitreal administration of sodium iodate on cynomolgus macaque macula over time. Macula cross sections taken with SD‐OCT. ABSTRACT The lack of effective treatments for dry age‐related macular degeneration (AMD) is in part due to a lack of a preclinical animal model that recapitulates features of the clinical state including macular ...
Rintaro Fujii, Mayumi Matsushita, Yoshitaka Itani, Aldric Hama, Takahiro Natsume, Hiroyuki Takamatsu   +5 more
wiley   +1 more source

Massively Parallel Screening of Toll/Interleukin‐1 Receptor (TIR)‐Derived Peptides Reveals Multiple Toll‐Like Receptors (TLRs)‐Targeting Immunomodulatory Peptides

Advanced Science, Volume 12, Issue 1, January 9, 2025.
Exploring TIR‐Binding Peptides for TLR‐Targeted Therapeutics: This study develops a comprehensive parallel screening method to discover novel TIR‐binding peptides from unexplored TIR domain surfaces. The constructed peptide library, TIR surfacesome, reveals hundreds of TIR‐binding peptides that inhibit TLR signaling, demonstrate anti‐inflammatory ...
Yun Lim, Tae Kyeom Kang, Meong Il Kim, Dohyeon Kim, Ji Yul Kim, Sang Hoon Jung, Keunwan Park, Wook‐Bin Lee, Moon‐Hyeong Seo   +8 more
wiley   +1 more source

A New Ocular Phenotype Combining Juvenile Glaucoma and Doyne Honeycomb Retinal Dystrophy (Malattia Leventinese) due to a Novel EFEMP1 Pathogenic Variant

American Journal of Medical Genetics Part A, Volume 197, Issue 1, January 2025.
ABSTRACT Doyne honeycomb retinal dystrophy (DHRD), also termed malattia leventinese (MLVT), is a dominantly inherited ocular disease characterized by the progressive accumulation of macular and peripapillary drusenoid material beneath the retinal pigment epithelium in the Bruch membrane.
Oscar F. Chacon‐Camacho, Thania Ordaz‐Robles, Marion A. Cid‐García, Olivia Yepes‐Rodríguez, Rocio Arce‐González, Alan Martínez‐Aguilar, Juan Carlos Zenteno   +6 more
wiley   +1 more source

Optic nerve head segmentation [PDF]

, 2004
Reliable and efficient optic disk localization and segmentation are important tasks in automated retinal screening. General-purpose edge detection algorithms often fail to segment the optic disk due to fuzzy boundaries, inconsistent image contrast or ...
Basu, A., Fletcher, E., Hunter, Andrew, Kennedy, L., Lowell, J., Ryder, R., Steel, D.   +6 more
core   +1 more source

Identifying the retinal layers from optical coherence tomography images using a 3D segmentation method

IET Image Processing, Volume 19, Issue 1, January/December 2025.
The paper proposes a novel automated method of retinal layer segmentation from spectral domain optical coherence tomography images in 3‐dimensional (3D) space. 3D segmentation utilizes more information than 2D segmentation and therefore leads to more accurate and reliable segmentation than 2D segmentation. This automated method performance demonstrates
Akter Hossain, Andrea Giani, Victor Chong, Sobha Sivaprasad, Tasin R. Bhuiyan, Theodore Smith, Manaswini Pradhan, Alauddin Bhuiyan   +7 more
wiley   +1 more source