Results 1 to 10 of about 136,615 (295)

Progress in Gene Therapy to Prevent Retinal Ganglion Cell Loss in Glaucoma and Leber’s Hereditary Optic Neuropathy

Neural Plasticity, 2018
The eye is at the forefront of the application of gene therapy techniques to medicine. In the United States, a gene therapy treatment for Leber’s congenital amaurosis, a rare inherited retinal disease, recently became the first gene therapy to be ...
Sara E. Ratican, Andrew Osborne, Keith R. Martin   +2 more
doaj   +1 more source

Gut microbiota regulates optic nerve fiber myelination

Frontiers in Cell and Developmental Biology
IntroductionRecent evidence supports the hypothesis of an association between gut microbiota and the pathogenesis of retinal and eye diseases, suggesting the existence of a gut-eye axis.
Giulia Ronchi, Davide Pellegrino, Marwa El Soury, Olga Amato, Francesco Gaia, Sajjad Farzin, Raffaele Nuzzi, Marijana Basic, Silvia Bolsega, Stefano Geuna, Matilde Cescon, Kirsten Haastert-Talini, Kirsten Haastert-Talini, Giovanna Gambarotta   +13 more
doaj   +1 more source

OPHTHALMOSCOPIC EVALUATION OF THE OPTIC NERVE HEAD

Zdravniški Vestnik, 2002
Background. Optic nerve diseases, such as glaucomas, lead to changes in the intrapapillary and parapapillary region of the optic nerve head.Conclusions.
Marija Zupan, Kristina Mikek, Smiljana Gruden   +2 more
doaj  

Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

Neural Regeneration Research
Several studies have found that transplantation of neural progenitor cells (NPCs) promotes the survival of injured neurons. However, a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical application ...
Tong Li, Hui-Min Xing, Hai-Dong Qian, Qiao Gao, Sheng-Lan Xu, Hua Ma, Zai-Long Chi   +6 more
doaj   +1 more source

Artificial Intelligence for Screening of Multiple Retinal and Optic Nerve Diseases.

JAMA Netw Open, 2022
Dong L, He W, Zhang R, Ge Z, Wang YX, Zhou J, Xu J, Shao L, Wang Q, Yan Y, Xie Y, Fang L, Wang H, Wang Y, Zhu X, Wang J, Zhang C, Wang H, Wang Y, Chen R, Wan Q, Yang J, Zhou W, Li H, Yao X, Yang Z, Xiong J, Wang X, Huang Y, Chen Y, Wang Z, Rong C, Gao J, Zhang H, Wu S, Jonas JB, Wei WB.   +36 more
europepmc   +1 more source

Axonal mitophagy in retinal ganglion cells

Cell Communication and Signaling
Neurons, exhibiting unique polarized structures, rely primarily on the mitochondrial production of ATP to maintain their hypermetabolic energy requirements.
Yang Liang, Yulin Li, Qing Jiao, Muyang Wei, Yan Wang, Aoteng Cui, Zhihui Li, Guangyu Li   +7 more
doaj   +1 more source

Animal models of optic nerve diseases [PDF]

Eye, 2004
openaire   +2 more sources

Chromatic Pupillometry Methods for Assessing Photoreceptor Health in Retinal and Optic Nerve Diseases. [PDF]

Front Neurol, 2019
Rukmini AV, Milea D, Gooley JJ.
europepmc   +1 more source

Environmental Exposures and Oxidative Stress in Retinal and Optic Nerve Diseases: Mechanisms, Consequences, and Therapeutic Opportunities. [PDF]

Antioxidants (Basel)
Roberson JK, Bauer AN, Lopez-Ramirez A, Jenness DB, Cruz Zayas S, Cooke Bailey JN, Woodlief TL.   +6 more
europepmc   +1 more source

The therapeutic potential of bone marrow mesenchymal stem cells-derived exosomes for retinal and optic nerve diseases. [PDF]

Front Cell Dev Biol
Shi M, Qi S, Qi F, Wang C.
europepmc   +1 more source