Results 21 to 30 of about 87,111 (260)

Optic Neuritis or Inflammatory Optic Neuropathy: a review

Journal of Ophthalmology, 2022
According to the literature, there are two equivalent terms "optic neuritis" and "inflammatory optic neuropathy". Classification, pathogenesis and clinical manifestations are ambiguous.
N. M. Moyseyenko
doaj   +1 more source

Toxic damage of the optic nerve by smoking a tobacco mixture using a hookah

Российский офтальмологический журнал, 2022
Recent years have seen an increase in tobacco mixture smokers using hookahs. Dangerous substances released during smoking cause substantial harm to the entire body, and bring about visual impairment with toxic optical neuropathy. Eye structures which are
E. E. Ioyleva, A. А. Bratchuk, M. R. Khabazova   +2 more
doaj   +1 more source

NRF2 Deficiency Disrupts Mitochondrial Homeostasis via NDUFS7 in Trabecular Meshwork

Research
The trabecular meshwork (TM) plays a pivotal role in maintaining intraocular pressure (IOP) by regulating aqueous humor outflow. Nuclear factor erythroid 2-related factor 2 (NRF2) was identified as a key transcriptional controller of TM redox balance and
Xuejing Yan, Shen Wu, Xiaowei Fan, Qian Li, Yufei Teng, Ningli Wang, Jingxue Zhang   +6 more
doaj   +1 more source

Role of Oxidative Stress in Ocular Diseases Associated with Retinal Ganglion Cells Degeneration

Antioxidants, 2021
Ocular diseases associated with retinal ganglion cell (RGC) degeneration is the most common neurodegenerative disorder that causes irreversible blindness worldwide. It is characterized by visual field defects and progressive optic nerve atrophy.
Eugene Yu-Chuan Kang, Pei-Kang Liu, Yao-Tseng Wen, Peter M. J. Quinn, Sarah R. Levi, Nan-Kai Wang, Rong-Kung Tsai   +6 more
doaj   +1 more source

Mechanical activation of PIEZO1 drives AP-1–dependent PTGS2/PGE2 signaling and corneal inflammation

iScience
Summary: Abnormal mechanical stimulation, such as eye rubbing, is a critical risk factor for corneal diseases, yet the molecular mechanisms linking mechanical stimulation to inflammation remain unclear.
Zongzheng Zou, Xiuqing Qian, Jifeng Ren, Yuqing Wang, Yuqi Liu, Aojun Luo, Mengyuan Guo, Hui Tong, Ruiran Li, Shanshan Li, Haixia Zhang   +10 more
doaj   +1 more source

Gene therapy for optic nerve disease [PDF]

Eye, 2004
There has been recent interest in the potential use of gene therapy techniques to treat ocular disease. In this article, we consider the optic nerve diseases that are potentially most amenable to gene therapy.We discuss the recent success of gene transfer experiments in animal models of glaucoma, optic neuritis, Leber's hereditary optic neuropathy ...
K R G, Martin, H A, Quigley
openaire   +2 more sources

Transcriptomic Differences Between Human Trabecular Meshwork Stem Cells and Trabecular Meshwork Cells Reveal Specific Biomarker Profiles

Current Issues in Molecular Biology
Glaucoma is a leading cause of irreversible blindness, normally associated with dysfunction and degeneration of the trabecular meshwork (TM) as the primary cause.
Rong Du, Ajay Kumar, Enzhi Yang, Jingxue Zhang, Ningli Wang, Yiqin Du   +5 more
doaj   +1 more source

Tempol improves optic nerve histopathology and ultrastructures in cisplatin-induced optic neuropathy in rats by targeting oxidative stress—Endoplasmic reticulum stress—Autophagy signaling pathways

Frontiers in Cellular Neuroscience, 2023
IntroductionOptic neuropathy is an affection of the optic neurons, which ends with blindness and occurs either primarily due to direct affection of the optic nerve or secondarily as a complication of chronic diseases and/or adverse effects of their ...
Amira Ebrahim Alsemeh, Mohey A. E. Hulail, Hanan E. L. Mokhtar, Reham Talaat Eldemerdash, Ioan Banatean-Dunea, Liana Mihaela Fericean, Maha Abdelhamid Fathy, Ahmed Hamed Arisha, Ahmed Hamed Arisha, Tarek Khamis, Tarek Khamis   +10 more
doaj   +1 more source

Guidelines for Pediatric Radiotherapy Simulation: A Report From the Children's Oncology Group Radiation Oncology Discipline

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric radiation therapy presents unique challenges compared to adult treatments, including those of immobilization, potential need for sedation, and the critical importance of accurate, reproducible positioning. Additionally, heightened attention to imaging doses is necessary to minimize long‐term toxicity in survivors.
Parham Alaei, Stephen Mihalcik, Sujith Baliga, Young Kwok, Dana Casey, Eric Ehler, Christiane Burton, John C. Breneman, Daphne A. Haas‐Kogan, Suzanne L. Wolden, Arnold C. Paulino, Nadia N. Laack, Natia Esiashvili, Sarah Milgrom, Christine Hill‐Kayser, Thomas J. Fitzgerald, John A. Kalapurakal, Chia‐Ho Hua   +17 more
wiley   +1 more source

Stem Cell Ophthalmology Treatment Study (SCOTS): bone marrow-derived stem cells in the treatment of Leber′s hereditary optic neuropathy

Neural Regeneration Research, 2016
The Stem Cell Ophthalmology Treatment Study (SCOTS) is currently the largest-scale stem cell ophthalmology trial registered at ClinicalTrials.gov (identifier: NCT01920867).
Jeffrey N Weiss, Steven Levy, Susan C Benes   +2 more
doaj   +1 more source