Results 31 to 40 of about 135,492 (203)

Tempol improves optic nerve histopathology and ultrastructures in cisplatin-induced optic neuropathy in rats by targeting oxidative stress—Endoplasmic reticulum stress—Autophagy signaling pathways

Frontiers in Cellular Neuroscience, 2023
IntroductionOptic neuropathy is an affection of the optic neurons, which ends with blindness and occurs either primarily due to direct affection of the optic nerve or secondarily as a complication of chronic diseases and/or adverse effects of their ...
Amira Ebrahim Alsemeh, Mohey A. E. Hulail, Hanan E. L. Mokhtar, Reham Talaat Eldemerdash, Ioan Banatean-Dunea, Liana Mihaela Fericean, Maha Abdelhamid Fathy, Ahmed Hamed Arisha, Ahmed Hamed Arisha, Tarek Khamis, Tarek Khamis   +10 more
doaj   +1 more source

Distribution of choline acetyltransferase (ChAT) immunoreactivity in the brain of the teleost cyprinus carpio [PDF]

, 2018
Cholinergic systems play a role in basic cerebral functions and its dysfunction is associated with deficit in neurodegenerative disease. Mechanisms involved in human brain diseases, are often approached by using fish models, especially cyprinids, given ...
Casini, Arianna, Cioni, Carla, Toni, Mattia, Vaccaro, Rosa   +3 more
core   +2 more sources

NRF2 Deficiency Disrupts Mitochondrial Homeostasis via NDUFS7 in Trabecular Meshwork

Research
The trabecular meshwork (TM) plays a pivotal role in maintaining intraocular pressure (IOP) by regulating aqueous humor outflow. Nuclear factor erythroid 2-related factor 2 (NRF2) was identified as a key transcriptional controller of TM redox balance and
Xuejing Yan, Shen Wu, Xiaowei Fan, Qian Li, Yufei Teng, Ningli Wang, Jingxue Zhang   +6 more
doaj   +1 more source

Pharmacogenetics of ophthalmic topical β-blockers [PDF]

, 2008
Glaucoma is the second leading cause of blindness worldwide. The primary glaucoma risk factor is elevated intraocular pressure. Topical β-blockers are affordable and widely used to lower intraocular pressure.
McCarty, Catherine A., Patchett, Richard, Sidjanin, Duska J., Smith, Edward M., Wilke, Russell A.   +4 more
core   +1 more source

Therapeutic potential of co-enzyme Q10 in retinal diseases [PDF]

, 2017
Coenzyme Q10 (CoQ10) plays a critical role in mitochondrial oxidative phosphorylation by serving as an electron carrier in the respiratory electron transport chain.
Marcheggiani, Fabio, Reilly, James, Shu, Xinhua, Tiano, Luca, Tohari, Ali Mohammad, Zhang, Xun, Zhou, Xinzhi   +6 more
core   +1 more source

Assessment of optic nerve and optic tract alterations in patients with orbital space-occupying lesions using probabilistic diffusion tractography [PDF]

International Journal of Ophthalmology, 2019
AIM: To investigate the diffusion changes in both the optic nerve and optic tract in orbital space-occupying lesion patients with decreased visual acuity, and its clinical significance using probabilistic diffusion tractography (PDT).
Chun-Nan Wu, Shao-Feng Duan, Xue-Tao Mu, Yi Wang, Peng-Yu Lan, Xiao-Lu Wang, Kun-Cheng Li   +6 more
doaj   +1 more source

Neuroprotection in a Novel Mouse Model of Multiple Sclerosis [PDF]

, 2013
The authors acknowledge the support of the Barts and the London Charity, the Multiple Sclerosis Society of Great Britain and Northern Ireland, the National Multiple Sclerosis Society, USA, notably the National Centre for the Replacement, Refinement ...
A Compston, AJ Coles, BB Thomas, C Bjartmar, CKS Leung, D Baker, DA Bechtold, David Baker, DB Fernandes, DW Hampton, E Bettelli, E Bettelli, F Hafezi, G Feng, G Pryce, Gavin Giovannoni, J Goverman, J Oh, JA Black, JA Cohen, JK O’Neill, JM Coquet, K Raju, Katie Lidster, KM Galetta, L Steinman, LS Talman, LS Talman, M Kleinewietfeld, Mark D. Baker, MM Morris-Downes, Pablo Villoslada, Pete Coffey, Peter Munro, R Dutta, R Kapoor, S Al-Izki, S Al-Izki, S Al-Izki, S Gnanapavan, S Mader, Samuel J. Jackson, SG Waxman, SJ Piddlesden, T Hayton, T Svingen, X Wang, Y Guan, Z Ahmed, Zubair Ahmed   +49 more
core   +4 more sources

Transcriptomic Differences Between Human Trabecular Meshwork Stem Cells and Trabecular Meshwork Cells Reveal Specific Biomarker Profiles

Current Issues in Molecular Biology
Glaucoma is a leading cause of irreversible blindness, normally associated with dysfunction and degeneration of the trabecular meshwork (TM) as the primary cause.
Rong Du, Ajay Kumar, Enzhi Yang, Jingxue Zhang, Ningli Wang, Yiqin Du   +5 more
doaj   +1 more source

Applications of Optical Coherence Tomography in Optic Nerve Head Diseases: A Narrative Review

Diagnostics
Optical coherence tomography (OCT) is a non-invasive imaging tool that is currently used in the evaluation and management of neuro-ophthalmic disorders. The detailed ability to visualize the optic nerve head, peripapillary retinal nerve fiber layer, and ...
Mohamed M. Khodeiry, Elizabeth Colvin, Mohammad Ayoubi, Ximena Mendoza, Maja Kostic   +4 more
doaj   +1 more source

Image analysis of optic nerve disease [PDF]

Eye, 2004
Existing methodologies for imaging the optic nerve head surface topography and measuring the retinal nerve fibre layer thickness include confocal scanning laser ophthalmoscopy (Heidelberg retinal tomograph), optical coherence tomography, and scanning laser polarimetry.
openaire   +2 more sources