Results 31 to 40 of about 253,994 (316)

Role of Oxidative Stress in Ocular Diseases Associated with Retinal Ganglion Cells Degeneration

Antioxidants, 2021
Ocular diseases associated with retinal ganglion cell (RGC) degeneration is the most common neurodegenerative disorder that causes irreversible blindness worldwide. It is characterized by visual field defects and progressive optic nerve atrophy.
Eugene Yu-Chuan Kang, Pei-Kang Liu, Yao-Tseng Wen, Peter M. J. Quinn, Sarah R. Levi, Nan-Kai Wang, Rong-Kung Tsai   +6 more
doaj   +1 more source

AxoNet: an AI-based tool to count retinal ganglion cell axons [PDF]

Sci Rep 10, 8034 (2020), 2019
Goal: In this work, we develop a robust, extensible tool to automatically and accurately count retinal ganglion cell axons in images of optic nerve tissue from various animal models of glaucoma. Methods: The U-Net convolutional neural network architecture was adapted to learn pixelwise axon count density estimates, which were then integrated over the ...
arxiv   +1 more source

Magnetic resonance imaging indicator of the causes of optic neuropathy in IgG4-related ophthalmic disease

BMC Medical Imaging, 2019
Background The following study investigates the involvement of optic neuropathy in IgG4-related ophthalmic diseases (IgG4-ROD) based on the magnetic resonance imaging (MRI) data, and different imaging features of IgG4-ROD related optic neuropathy related
Jing Li, Yan Zhang, Hang Zhou, Lei Wang, Zhenchang Wang, Hongyang Li   +5 more
doaj   +1 more source

Tempol improves optic nerve histopathology and ultrastructures in cisplatin-induced optic neuropathy in rats by targeting oxidative stress—Endoplasmic reticulum stress—Autophagy signaling pathways

Frontiers in Cellular Neuroscience, 2023
IntroductionOptic neuropathy is an affection of the optic neurons, which ends with blindness and occurs either primarily due to direct affection of the optic nerve or secondarily as a complication of chronic diseases and/or adverse effects of their ...
Amira Ebrahim Alsemeh, Mohey A. E. Hulail, Hanan E. L. Mokhtar, Reham Talaat Eldemerdash, Ioan Banatean-Dunea, Liana Mihaela Fericean, Maha Abdelhamid Fathy, Ahmed Hamed Arisha, Ahmed Hamed Arisha, Tarek Khamis, Tarek Khamis   +10 more
doaj   +1 more source

Assessment of optic nerve and optic tract alterations in patients with orbital space-occupying lesions using probabilistic diffusion tractography [PDF]

International Journal of Ophthalmology, 2019
AIM: To investigate the diffusion changes in both the optic nerve and optic tract in orbital space-occupying lesion patients with decreased visual acuity, and its clinical significance using probabilistic diffusion tractography (PDT).
Chun-Nan Wu, Shao-Feng Duan, Xue-Tao Mu, Yi Wang, Peng-Yu Lan, Xiao-Lu Wang, Kun-Cheng Li   +6 more
doaj   +1 more source

Automatic Segmentation of the Optic Nerve Head Region in Optical Coherence Tomography: A Methodological Review [PDF]

arXiv, 2021
The optic nerve head represents the intraocular section of the optic nerve (ONH), which is prone to damage by intraocular pressure. The advent of optical coherence tomography (OCT) has enabled the evaluation of novel optic nerve head parameters, namely the depth and curvature of the lamina cribrosa (LC).
arxiv  

The Prevalence of diabetic optic neuropathy in type 2 diabetes mellitus [PDF]

Zanco Journal of Medical Sciences, 2017
Background and objective: As diabetes mellitus a common health problem, it is well known that it can lead to optic neuropathy that affects the optic nerve functions.
Ali A. Taqi Al-Saffar
doaj   +1 more source

Stem Cell Ophthalmology Treatment Study (SCOTS): bone marrow-derived stem cells in the treatment of Leber′s hereditary optic neuropathy

Neural Regeneration Research, 2016
The Stem Cell Ophthalmology Treatment Study (SCOTS) is currently the largest-scale stem cell ophthalmology trial registered at ClinicalTrials.gov (identifier: NCT01920867).
Jeffrey N Weiss, Steven Levy, Susan C Benes   +2 more
doaj   +1 more source

Supervised Segmentation with Domain Adaptation for Small Sampled Orbital CT Images [PDF]

arXiv, 2021
Deep neural networks (DNNs) have been widely used for medical image analysis. However, the lack of access a to large-scale annotated dataset poses a great challenge, especially in the case of rare diseases, or new domains for the research society. Transfer of pre-trained features, from the relatively large dataset is a considerable solution.
arxiv  

Scattered Light Imaging: Resolving the substructure of nerve fiber crossings in whole brain sections with micrometer resolution [PDF]

NeuroImage 233, 117952 (2021), 2020
For developing a detailed network model of the brain based on image reconstructions, it is necessary to spatially resolve crossing nerve fibers. The accuracy hereby depends on many factors, including the spatial resolution of the imaging technique. 3D Polarized Light Imaging (3D-PLI) allows the three-dimensional reconstruction of nerve fiber tracts in ...
arxiv   +1 more source