Caveolin-1 defines astrocyte mechanobiology in the glial lamina of the optic nerve head [PDF]
Frontiers in Cellular NeuroscienceThe optic nerve head is the principal site of retinal ganglion cell axonal injury in primary open angle glaucoma, where astrocyte mechanobiology and extracellular matrix remodeling are thought to play critical roles in disease progression.
Anja K. Hoffmann +9 more
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Multimodal imaging and clinical evolution of an optic nerve head granuloma with prominent overlying vessels in ocular sarcoidosis: a case report and literature review [PDF]
Frontiers in NeurologyBackgroundSarcoidosis is a multisystem granulomatous disorder of unclear etiology, histopathologically characterized by noncaseating granulomas. Ocular involvement is among the most common extrapulmonary manifestations, whereas optic nerve involvement ...
Jiahao Xiong, Jiyue Tan, Jun Xiao
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Applications of Optical Coherence Tomography in Optic Nerve Head Diseases: A Narrative Review [PDF]
DiagnosticsOptical coherence tomography (OCT) is a non-invasive imaging tool that is currently used in the evaluation and management of neuro-ophthalmic disorders. The detailed ability to visualize the optic nerve head, peripapillary retinal nerve fiber layer, and ...
Mohamed M. Khodeiry +4 more
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Cyclic stretch increases transglutaminase 2-mediated serotonylation of extracellular fibronectin in cultured optic nerve head astrocytes: a pilot study [PDF]
Matrix Biology PlusBackground: Glaucoma is a leading cause of blindness characterized by progressive degeneration of the optic nerve. Elevated intraocular pressure, typically associated with glaucoma, exerts biomechanical strain on the optic nerve head, where ...
Rajiv S. Rangan +9 more
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Stretch stress propels glutamine dependency and glycolysis in optic nerve head astrocytes
Frontiers in Neuroscience, 2022 Glaucoma is an optic neuropathy that leads to irreversible blindness, the most common subtype of which is typified by a chronic increase in intraocular pressure that promotes a stretch injury to the optic nerve head.
Nathaniel Pappenhagen +4 more
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Papilledema in Space Flight: Pathogenesis, Diagnostics and Monitoring
Oftalʹmologiâ, 2020 Some Russian cosmonauts in space flight have revealed swelling of the optic nerve head of varying severity. Four clinical cases presented in this article.
I. A. Makarov, S. N. Danilichev
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American Journal of Ophthalmology Case Reports, 2022 Purpose: Blunt ocular trauma rarely results in optic nerve avulsion. Here, we report a case of incomplete optic nerve avulsion caused by the impact of a badminton shuttlecock. Observations: The patient was a 16-year-old healthy male.
Yuto Kawamata +3 more
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The Automated Expert Support System for Optic Nerve Head Morphological Description
Oftalʹmologiâ, 2020 Purpose. To develop the automated expert support system for optic nerve head morphological description in normal conditions and in pathology.Methods. The proposed expert support system is based on the integration algorithm of luminance samples along the ...
E. G. Tanaeva, R. G. Khafizov
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Frontiers in Neurology, 2020 Indirect traumatic optic neuropathy (ITON) is an injury to the optic nerve due to head trauma and usually results in partial or complete loss of vision. In order to advance a mechanistic understanding of the injury to the optic nerve, we developed a head
Yang Li +6 more
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Atypical acute presentation of an optic nerve sheath meningioma
American Journal of Ophthalmology Case Reports, 2020 Purpose: Primary optic nerve sheath meningiomas (ONSM) are benign lesions that typically present with findings of painless proptosis (59%), optic nerve pallor (55%), and decreased peripheral vision (35%). Herein we share an atypical case of a patient who
Cole Holan +3 more
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