Stretch stress propels glutamine dependency and glycolysis in optic nerve head astrocytes [PDF]
Frontiers in Neuroscience, 2022 Glaucoma is an optic neuropathy that leads to irreversible blindness, the most common subtype of which is typified by a chronic increase in intraocular pressure that promotes a stretch injury to the optic nerve head.
Nathaniel Pappenhagen +4 more
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Optic nerve head astrocytes contribute to vascular associated effects [PDF]
Frontiers in Medicine, 2022 PurposeThis study was conducted in order to test the expression of vasoactive substances within rat lamina cribrosa (LC) and optic nerve head (ONH) astrocytes, so as to investigate the role and potential mechanism of ONH astrocytes in vascular associated
Yanmin Dong +8 more
doaj +4 more sources
Differential Activation of Glioprotective Intracellular Signaling Pathways in Primary Optic Nerve Head Astrocytes after Treatment with Different Classes of Antioxidants [PDF]
Antioxidants, 2020 Optic nerve head astrocytes are the specialized glia cells that provide structural and trophic support to the optic nerve head. In response to cellular injury, optic nerve head astrocytes undergo reactive astrocytosis, the process of cellular activation ...
Anita K. Ghosh +7 more
doaj +4 more sources
Astrocyte heterogeneity within white matter tracts and a unique subpopulation of optic nerve head astrocytes [PDF]
iScience, 2022 Summary: Much of what we know about astrocyte form and function is derived from the study of gray matter protoplasmic astrocytes, whereas white matter fibrous astrocytes remain relatively unexplored. Here, we used the ribotag approach to isolate ribosome-
Arpan G. Mazumder +3 more
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Cyclic stretch increases transglutaminase 2-mediated serotonylation of extracellular fibronectin in cultured optic nerve head astrocytes: a pilot study [PDF]
Matrix Biology PlusBackground: Glaucoma is a leading cause of blindness characterized by progressive degeneration of the optic nerve. Elevated intraocular pressure, typically associated with glaucoma, exerts biomechanical strain on the optic nerve head, where ...
Rajiv S. Rangan +9 more
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The role of aquaporin-4 in optic nerve head astrocytes in experimental glaucoma. [PDF]
PLoS ONE, 2021 PurposeTo study aquaporin channel expression in astrocytes of the mouse optic nerve (ON) and the response to IOP elevation in mice lacking aquaporin 4 (AQP4 null).MethodsC57BL/6 (B6) and AQP4 null mice were exposed to bead-induced IOP elevation for 3 ...
Elizabeth Kimball +6 more
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Caveolin-1 defines astrocyte mechanobiology in the glial lamina of the optic nerve head [PDF]
Frontiers in Cellular NeuroscienceThe optic nerve head is the principal site of retinal ganglion cell axonal injury in primary open angle glaucoma, where astrocyte mechanobiology and extracellular matrix remodeling are thought to play critical roles in disease progression.
Anja K. Hoffmann +9 more
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Neurobiology of Disease, 2003 3α-Hydroxysteroid dehydrogenase (3α-HSD) isoforms (AKR1C1–AKR1C4) are aldo-keto reductases that metabolize steroids and other substances in many tissues including the CNS.
O.A Agapova +6 more
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Sigma 1 receptor regulates ERK activation and promotes survival of optic nerve head astrocytes. [PDF]
PLoS ONE, 2017 The sigma 1 receptor (S1R) is a unique transmembrane protein that has been shown to regulate neuronal differentiation and cellular survival. It is expressed within several cell types throughout the nervous system and visceral organs, including neurons ...
Jing Zhao +5 more
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Astrocyte responses to experimental glaucoma in mouse optic nerve head.
PLoS ONE, 2020 PurposeTo delineate responses of optic nerve head astrocytes to sustained intraocular pressure (IOP) elevation in mice.MethodsWe elevated IOP for 1 day to 6 weeks by intracameral microbead injection in 4 strains of mice.
Sarah Quillen +5 more
doaj +3 more sources