Results 31 to 40 of about 1,824,086 (180)

Optic nerve head: A gatekeeper for vitreous infectious insults?

Frontiers in Immunology, 2022
The axons of retinal ganglion cells (RGCs) pass through the optic nerve head (ONH) and form the optic nerve (ON). The ONH serves as an anatomical interface between the vitreous cavity and subarachnoid space.
Wenwen Lai, Wenwen Lai, Jie Huang, Jie Huang, Wangyi Fang, Saiyue Deng, Yi Xie, Wei Wang, Tong Qiao, Gezhi Xu, Gezhi Xu, Xiaowei Wang, Fengfei Ding, Fengfei Ding   +13 more
doaj   +1 more source

Data_Sheet_1_Stretch stress propels glutamine dependency and glycolysis in optic nerve head astrocytes.PDF

, 2022
Glaucoma is an optic neuropathy that leads to irreversible blindness, the most common subtype of which is typified by a chronic increase in intraocular pressure that promotes a stretch injury to the optic nerve head.
Eric Yin (1797763), Denise M. Inman (13202796), Charles C. Kiehlbauch (13202793), Autumn B. Morgan (13202790), Nathaniel Pappenhagen (13202787)   +4 more
core   +1 more source

Activation of epidermal growth factor receptor signals induction of nitric oxide synthase-2 in human optic nerve head astrocytes in glaucomatous optic neuropathy

Neurobiology of Disease, 2003
Glaucoma is an optic neuropathy that is associated with elevated intraocular pressure in most patients. We have previously demonstrated that the mechanism by which pressure damages optic nerve axons involves excessive nitric oxide generated by inducible ...
Bin Liu, Arthur H Neufeld
doaj   +1 more source

Network analysis of human glaucomatous optic nerve head astrocytes

BMC Medical Genomics, 2009
Background Astrocyte activation is a characteristic response to injury in the central nervous system, and can be either neurotoxic or neuroprotective, while the regulation of both roles remains elusive.
Bhattacharya Sanjoy K, Yankovsky Nick, Rahkmatulin Eugene, Brennan Richard J, Dezso Zoltan, Sviridov Eugene, Zvereva Svetlana, Serebryiskaya Tatiana, Nikolsky Yuri, Nikolskaya Tatiana, Agapova Olga, Hernandez M Rosario, Shestopalov Valery I   +12 more
doaj   +1 more source

Quantitative MRI Uncovers Subtle Cortical Damage in Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether myelin‐sensitive quantitative MRI reveals microstructural abnormalities in normal‐appearing cortex (NACtx) in myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), indicating that conventional MRI underestimates remission residual cortical injury.
Valentina Camera, Agnese Tamanti, Silvia Messina, Nicola Dall'Osto, Teresa Maltempo, Stefano Ziccardi, Matteo Foschi, Maria Grazia Piscaglia, Diana Ferraro, Francesco Crescenzo, Francesca Rossi, Albulena Bajrami, Sabrina Marangoni, Damiano Marastoni, Francesca Benedetta Pizzini, Maria Isabel Leite, Roberta Magliozzi, Patrick Waters, Massimiliano Calabrese, Jacqueline Palace, Ruth Geraldes   +20 more
wiley   +1 more source

Astrocyte polarization in glaucoma: a new opportunity

Neural Regeneration Research, 2022
Astrocyte polarization is a new concept which is similar to microglia polarization and in which astrocytes are classified as A1 (neurotoxic) and A2 (neuroprotective).
Yi-Xin Liu, Hao Sun, Wen-Yi Guo
doaj   +1 more source

Additively Manufactured Geometry‐Reconfigurable Soft Neural Probes With Monolithic Multifunctionality

Advanced Functional Materials, EarlyView.
A geometry‐reconfigured additive manufacturing strategy converts planar printed soft materials into soft compact neural probes with integrated hydrogel electrodes and microfluidic channels. The resulting NeuroMAP platform enables scalable multichannel recording, localized chemical delivery, stable in vivo electrophysiological recording, and reduced ...
Hyunjin Lee, Xinyi Wang, Sirui Li, Jihyang Park, Hyunseok Lee, Jianting Yao, Kedar Narayan, Yuqi Wang, Jiashu Ren, Yueqi Deng, Salahuddin Ahmed, Denver I. Greenawalt, Archana Pandiyan, Loganathan Veeramuthu, Chi‐Ching Kuo, Tao Zhou   +15 more
wiley   +1 more source

Early reduction of microglia activation by irradiation in a model of chronic glaucoma. [PDF]

PLoS ONE, 2012
Glaucoma is a neurodegenerative disease that results in the progressive decline and ultimate death of retinal ganglion cells (RGCs). While multiple risk factors are associated with glaucoma, the mechanisms leading to onset and progression of the disease ...
Alejandra Bosco, Samuel D Crish, Michael R Steele, Cesar O Romero, Denise M Inman, Philip J Horner, David J Calkins, Monica L Vetter   +7 more
doaj   +1 more source

CCN2/CTGF—A Modulator of the Optic Nerve Head Astrocyte

Frontiers in Cell and Developmental Biology, 2022
In primary open-angle glaucoma (POAG), a neurodegenerative disease of the optic nerve (ON) and leading cause of blindness, the optic nerve head (ONH) undergoes marked structural extracellular matrix (ECM) changes, which contribute to its permanent ...
Andrea E. Dillinger, Gregor R. Weber, Matthias Mayer, Magdalena Schneider, Corinna Göppner, Andreas Ohlmann, Mikhail Shamonin, Gareth J. Monkman, Rudolf Fuchshofer   +8 more
doaj   +1 more source

Human iPSC‐Derived Tissue‐Engineered Nigrostriatal Pathway for Chronic Restoration of Dopaminergic Axon Tracts in a Rat Parkinson's Model

Advanced Healthcare Materials, EarlyView.
Inspired by conventional cell therapy and emerging bioengineering approaches, the tissue‐engineered nigrostriatal pathway (TE‐NSP) has an anatomically‐inspired design comprising a population of human dopaminergic neurons with unidirectional, long‐projecting axon tracts.
Wisberty J. Gordián‐Vélez, Dimple Chouhan, Kevin D. Browne, James Lim, Saarang P. Karandikar, Rodrigo A. España, John E. Duda, H. Isaac Chen, D. Kacy Cullen   +8 more
wiley   +1 more source