Results 11 to 20 of about 1,824,086 (180)

Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure

Molecular Neurodegeneration, 2023
Background The optic nerve is an important tissue in glaucoma and the unmyelinated nerve head region remains an important site of many early neurodegenerative changes. In both humans and mice, astrocytes constitute the major glial cell type in the region,
Arpan G. Mazumder, Amélie M. Julé, Daniel Sun   +2 more
doaj   +2 more sources

cAMP/PKA pathway and mitochondrial protection in oxidative stress-induced optic nerve head astrocytes [PDF]

Neural Regeneration Research, 2021
Keun-Young Kim, Won-Kyu Ju
doaj   +2 more sources

Stretch strain shifts optic nerve head astrocyte metabolism to enrich α-ketoglutarate and the pentose phosphate pathway [PDF]

Scientific Reports
Optic nerve head (ONH) astrocyte deformation contributes to glaucoma pathology by increasing extracellular matrix (ECM) deposition which promotes fibrosis in the ONH.
Usa Suwannasual, Katherine R. Smart, Olivia Young, Eul Hyun Suh, Teresa D. Golden, Denise M. Inman   +5 more
doaj   +2 more sources

Astrocytes from lamina cribrosa are involved in the autoregulatory function of optic nerve head vessels in vitro

Frontiers in Molecular Biosciences
PurposeTo investigate the role of the lamina cribrosa (LC) astrocytes in the autoregulatory capacity of optic nerve head (ONH) vessels and to explore the underlying molecular mechanisms.MethodsThe Oxygen-glucose deprivation/reperfusion model (OGD/R) in ...
Xiaoxiao Feng, Xiaoxiao Feng, Wenjia Zhang, Wenjia Zhang, Tingting Wan, Tingting Wan, Kangwei Jiao, Kangwei Jiao, Liwei Zhang, Liwei Zhang, Changhui Li, Changhui Li, Libo Xiao, Libo Xiao   +13 more
doaj   +3 more sources

Astrocytes in the optic nerve head express putative mechanosensitive channels

, 2015
Purpose To establish whether optic nerve head astrocytes express candidate molecules to sense tissue stretch. Methods: We used conventional PCR, quantitative PCR, and single-cell reverse transcription PCR (RT–PCR) to assess the expression of various ...
Sun, Daniel, Jakobs, Tatjana, Choi, Hee Joo   +2 more
core   +5 more sources

Aquaporin 4 is not present in normal porcine and human lamina cribrosa

PLoS ONE, 2022
Aquaporin 4 is absent from astrocytes in the rodent optic nerve head, despite high expression in the retina and myelinated optic nerve. The purpose of this study was to quantify regional aquaporin channel expression in astrocytes of the porcine and human
Elizabeth C. Kimball, Sarah Quillen, Mary E. Pease, Casey Keuthan, Aru Nagalingam, Donald J. Zack, Thomas V. Johnson, Harry A. Quigley   +7 more
doaj   +2 more sources

Astrocytes in the Optic Nerve Are Heterogeneous in Their Reactivity to Glaucomatous Injury

Cells, 2023
The optic nerve head is thought to be the site of initial injury to retinal ganglion cell injury in glaucoma. In the initial segment of the optic nerve directly behind the globe, the ganglion cell axons are unmyelinated and come into direct contact to ...
Ying Zhu, Rui Wang, Anthony C. Pappas, Philip Seifert, Andrej Savol, Ruslan I. Sadreyev, Daniel Sun, Tatjana C. Jakobs   +7 more
doaj   +1 more source

The heterogeneity of astrocytes in glaucoma

Frontiers in Neuroanatomy, 2022
Glaucoma is a leading cause of blindness with progressive degeneration of retinal ganglion cells. Aging and increased intraocular pressure (IOP) are major risk factors. Lowering IOP does not always stop the disease progression.
Yunjing Tang, Yunjing Tang, Yongjiang Chen, Danian Chen, Danian Chen   +4 more
doaj   +1 more source

Pathogenesis of Glaucoma

Encyclopedia, 2022
Glaucoma, a neurodegenerative disease, has a varied pathogenesis scenario, including elevated intraocular pressure (IOP), and hypoxic conditions in the retina.
Jason Macanian, Sansar C. Sharma
doaj   +1 more source

Astrocytes of the eye and optic nerve: heterogeneous populations with unique functions mediate axonal resilience and vulnerability to glaucoma

Frontiers in Ophthalmology, 2023
The role of glia, particularly astrocytes, in mediating the central nervous system’s response to injury and neurodegenerative disease is an increasingly well studied topic.
Paul F. Cullen, Daniel Sun
doaj   +1 more source