Reactive astrocytes and therapeutic potential in focal ischemic stroke
Neurobiology of Disease, 2016 Astrocytes are specialized and the most abundant cell type in the central nervous system (CNS). They play important roles in the physiology of the brain.
Gourav Roy Choudhury, Shinghua Ding
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Downregulation of STAT3 transcription factor reverses synaptotoxic phenotype of reactive astrocytes associated with prion diseases [PDF]
Acta Neuropathologica CommunicationsIn neurodegenerative diseases, including prion diseases, astrocytes adopt reactive phenotypes that persist throughout disease progression. While astrocyte reactivity may initially serve as a protective response to prion infection, it transitions into a ...
Rajesh Kushwaha +3 more
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Research progress on the role of exercise-regulated reactive astrocytes in the prevention and treatment of Parkinson’s disease [PDF]
Frontiers in Aging NeuroscienceAstrocytes generally perform protective roles, such as the release of neurotrophic factors, glutamate metabolism, transfer of healthy mitochondria to neurons, and maintenance of the blood-brain barrier. Nonetheless, in the context of Parkinson’s disease (
Quan Yang, Chunyu Zhuang
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Optogenetic regulation of chloride ions in reactive astrocytes may mitigate Parkinson’s disease pathology [PDF]
Scientific ReportsRecent investigations underscore the pivotal role of reactive astrocytes in the pathogenesis of Parkinson’s disease (PD). As PD advances, reactive astrocytes lose their ability to degrade α-Synuclein (α-Syn) aggregates while concurrently increasing r ...
Eun Jung Lee +2 more
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The GLP1R Agonist Semaglutide Inhibits Reactive Astrocytes and Enhances the Efficacy of Neural Stem Cell Transplantation Therapy in Parkinson's Disease Mice [PDF]
Advanced ScienceCell transplantation offers a promising approach for treating Parkinson's disease (PD), but the limited survival of transplanted cells remains a major challenge. Reactive astrocytes, abundant in PD brains, may exacerbate this issue.
Dan Song +6 more
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Protocol for the longitudinal study of neuroinflammation and reactive astrocytes in Lcn2CreERT2 mice [PDF]
STAR ProtocolsSummary: During brain disease, astrocytes can reprogram into a reactive state that alters many of their functions. Here, we present a protocol for studying neuroinflammation and reactive astrogliosis in mice using lipopolysaccharide (LPS) from E.
Teresa Ubina +5 more
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The Diverse Roles of Reactive Astrocytes in the Pathogenesis of Amyotrophic Lateral Sclerosis [PDF]
Brain SciencesAstrocytes displaying reactive phenotypes are characterized by their ability to remodel morphologically, molecularly, and functionally in response to pathological stimuli.
Kangqin Yang, Yang Liu, Min Zhang
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Frontiers in Cellular Neuroscience, 2023 Accaumulating studies focus on the effects of C3-positive A1-like phenotypes and S100A10-positive A2-like phenotypes of reactive astrocytes on spinal cord injury (SCI), however the origins and dynamic changes of C3- and S100A10-positive reactive ...
Qing Zhao +11 more
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Advances of researches on astrocytes in inflammatory diseases of central nervous system [PDF]
Jichu yixue yu linchuang, 2023 Astrocytes respond to various forms of central nervous system (CNS) damage which are activated to be reactive astrocytes and participate in tissue repairing, initiation and progression of neuroinflammatory diseases in CNS through neuroprotective or ...
LI Liya, QIN Pei
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Non-cell autonomous astrocyte-mediated neuronal toxicity in prion diseases
Acta Neuropathologica Communications, 2021 Under normal conditions, astrocytes perform a number of important physiological functions centered around neuronal support and synapse maintenance. In neurodegenerative diseases including Alzheimer’s, Parkinson’s and prion diseases, astrocytes acquire ...
Rajesh Kushwaha +4 more
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