Results 11 to 20 of about 915,551 (289)

Abnormal mitosis in reactive astrocytes [PDF]

Acta Neuropathologica Communications, 2020
Although abnormal mitosis with disarranged metaphase chromosomes or many micronuclei in astrocytes (named “Alzheimer I type astrocytes” and later “Creutzfeldt-Peters cells”) have been known for nearly 100 years, the origin and mechanisms of this ...
Alexander Sosunov, Xiaoping Wu, Robert McGovern, Charles Mikell, Guy M. McKhann, James E. Goldman   +5 more
doaj   +6 more sources

Heterogeneity of reactive astrocytes [PDF]

Neuroscience Letters, 2014
Astrocytes respond to injury and disease in the central nervous system (CNS) with a process referred to as reactive astrogliosis. Recent progress demonstrates that reactive astrogliosis is not a simple all-or-none phenomenon, but is a finely gradated continuum of changes that range from reversible alterations in gene expression and cell hypertrophy, to
Anderson, Mark A, Ao, Yan, Sofroniew, Michael V   +2 more
openaire   +6 more sources

Reactive Astrocytes in Brain Metastasis [PDF]

Frontiers in Oncology, 2017
Brain metastasis, the secondary growth of malignant cells within the central nervous system (CNS), exceeds the incidence of primary brain tumors (i.e., gliomas) by tenfold and are seemingly on the rise owing to the emergence of novel targeted therapies ...
David Wasilewski, Neibla Priego, Coral Fustero-Torre, Manuel Valiente   +3 more
doaj   +4 more sources

Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1

Stem Cell Reports, 2017
Summary: Amyotrophic lateral sclerosis (ALS) is a fatal and rapidly progressing motor neuron disease. Astrocytic factors are known to contribute to motor neuron degeneration and death in ALS.
Pratibha Tripathi, Natalia Rodriguez-Muela, Joseph R. Klim, A. Sophie de Boer, Sahil Agrawal, Jackson Sandoe, Claudia S. Lopes, Karolyn Sassi Ogliari, Luis A. Williams, Matthew Shear, Lee L. Rubin, Kevin Eggan, Qiao Zhou   +12 more
doaj   +2 more sources

β-lactolin, a Monoamine Oxidase B Inhibitory Lactopeptide, Suppresses Reactive Oxygen Species Production in Lipopolysaccharide-Stimulated Astrocytes

Applied Sciences, 2021
Astrocytes are known to regulate normal brain function. Monoamine oxidase B (MAO-B), an enzyme highly expressed in astrocytes, metabolizes dopamine (DA) and induces reactive oxygen species (ROS) production.
Shiori Akiyama, Tatsuhiro Ayabe, Chika Takahashi, Rena Ohya, Yasuhisa Ano   +4 more
doaj   +2 more sources

An update on reactive astrocytes in chronic pain [PDF]

Journal of Neuroinflammation, 2019
Chronic pain is a critical clinical problem with an increasing prevalence. However, there are limited effective prevention measures and treatments for chronic pain.
Ting Li, Xuhui Chen, Chuanhan Zhang, Yue Zhang, Wenlong Yao   +4 more
doaj   +3 more sources

Reactive astrocytes secrete the chaperone HSPB1 to mediate neuroprotection. [PDF]

Sci Adv
Molecular chaperones are protective in neurodegenerative diseases by preventing protein misfolding and aggregation, such as extracellular amyloid plaques and intracellular tau neurofibrillary tangles in Alzheimer’s disease (AD).
Yang F, Beltran-Lobo P, Sung K, Goldrick C, Croft CL, Nishimura A, Hedges E, Mahiddine F, Troakes C, Golde TE, Perez-Nievas BG, Hanger DP, Noble W, Jimenez-Sanchez M.   +13 more
europepmc   +7 more sources

SRF is required for maintenance of astrocytes in non-reactive state in the mammalian brain [PDF]

, 2021
Astrocytes play several critical roles in the normal functioning of the mammalian brain, including ion homeostasis, synapse formation, and synaptic plasticity.
Gutmann, David H, Ramanan, Narendrakumar, Soman, Sumitha, Das, Soumen, Virmani, Garima, Jain, Monika, Lu, Paul P Y, Thumu, Surya Chandra Rao, Monika Jain, Sumitha Soman, David H. Gutmann, Narendrakumar Ramanan, Paul P. Y. Lu, Soumen Das, Garima Virmani, Surya Chandra Rao Thumu   +15 more
core   +1 more source

Notch1 and Galectin-3 Modulate Cortical Reactive Astrocyte Response After Brain Injury

Frontiers in Cell and Developmental Biology, 2021
After a brain lesion, highly specialized cortical astrocytes react, supporting the closure or replacement of the damaged tissue, but fail to regulate neural plasticity.
Tais Novaki Ribeiro, Lina Maria Delgado-García, Marimelia A. Porcionatto   +2 more
doaj   +1 more source

The Role of Reactive Astrocytes in Brain Ischemia and Neurotrauma [PDF]

, 2006
Astrocytes are the most abundant cell type in the central nervous system (CNS) and increasing evidence now suggests that they play an active role in various brain functions.
Li, Lizhen 1977-, Li, Lizhen
core   +2 more sources