Results 21 to 30 of about 915,551 (289)
Neurotoxic Reactive Astrocytes Drive Defective Myelination in Acute Perinatal White Matter Injury. [PDF]
, 2022 Introduction: Acute perinatal white matter injury (apWMI) is the most common form of brain injury in preterm infants, yet the mechanisms underlying neurologic dysmaturation in this disease are far from understood.
Renz, Patricia +6 more
core +2 more sources
Astrocytic 4R tau expression drives astrocyte reactivity and dysfunction [PDF]
JCI Insight, 2022 The protein tau and its isoforms are associated with several neurodegenerative diseases, many of which are characterized by greater deposition of the 4-repeat (4R) tau isoform; however, the role of 4R tau in disease pathogenesis remains unclear. We created antisense oligonucleotides (ASOs) that alter the ratio of 3R to 4R tau to investigate the role of
Lubov A. Ezerskiy +9 more
openaire +4 more sources
Journal of Pharmacological Sciences, 2020 The pathophysiological roles of astrocytes in the reactive state are thought to have important significance in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD).
Moonseok Choi +3 more
doaj +1 more source
Reactive astrogliosis in the era of single-cell transcriptomics
Frontiers in Cellular Neuroscience, 2023 Reactive astrogliosis is a reaction of astrocytes to disturbed homeostasis in the central nervous system (CNS), accompanied by changes in astrocyte numbers, morphology, and function.
Zuzana Matusova +9 more
doaj +1 more source
Roles of neuropathology-associated reactive astrocytes: a systematic review
Acta Neuropathologica Communications, 2023 In the contexts of aging, injury, or neuroinflammation, activated microglia signaling with TNF-α, IL-1α, and C1q induces a neurotoxic astrocytic phenotype, classified as A1, A1-like, or neuroinflammatory reactive astrocytes.
Jill M. Lawrence +3 more
doaj +1 more source
The Specific Role of Reactive Astrocytes in Stroke [PDF]
Frontiers in Cellular Neuroscience, 2022 Astrocytes are essential in maintaining normal brain functions such as blood brain barrier (BBB) homeostasis and synapse formation as the most abundant cell type in the central nervous system (CNS). After the stroke, astrocytes are known as reactive astrocytes (RAs) because they are stimulated by various damage-associated molecular patterns (DAMPs) and
Leiyang Li +13 more
openaire +3 more sources
TGF-beta(2)- and H2O2-Induced Biological Changes in Optic Nerve Head Astrocytes Are Reduced by the Antioxidant Alpha-Lipoic Acid [PDF]
, 2012 Background/Aims: The goal of the present study was to determine whether transforming growth factor-beta(2) (TGF-beta(2))- and oxidative stress-induced cellular changes in cultured human optic nerve head (ONH) astrocytes could be reduced by pretreatment ...
Yu, Alice L. +2 more
core +1 more source
Gene expression profiles of reactive astrocytes cultured from dopamine-depleted striatum
Neurobiology of Disease, 2005 We have carried out cDNA array analysis in order to characterize the gene expression profiles of reactive astrocytes from dopamine-depleted striatum.
Takao Nakagawa +2 more
doaj +1 more source
Crosstalk of Astrocytes and Other Cells during Ischemic Stroke
Life, 2022 Stroke is a leading cause of death and long-term disability worldwide. Astrocytes structurally compose tripartite synapses, blood–brain barrier, and the neurovascular unit and perform multiple functions through cell-to-cell signaling of neurons, glial ...
Tingting He, Guo-Yuan Yang, Zhijun Zhang
doaj +1 more source
Neural Regeneration Research, 2021 Our previous study has confirmed that astrocytes overexpressing neurogenic differentiation factor 1 (NEUROD1) in the spinal cord can be reprogrammed into neurons under in vivo conditions.
Wen-Hao Chen +5 more
doaj +1 more source