Results 1 to 10 of about 21,947 (115)
A1 astrocytes contribute to murine depression-like behavior and cognitive dysfunction, which can be alleviated by IL-10 or fluorocitrate treatment [PDF]
Journal of Neuroinflammation, 2020 Background Astrocytes are crucial regulators in the central nervous system. Abnormal activation of astrocytes contributes to some behavior deficits. However, mechanisms underlying the effects remain unclear.
He-Yang Zhang +10 more
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Effects of FGF2/FGFR1 Pathway on Expression of A1 Astrocytes After Infrasound Exposure [PDF]
Frontiers in Neuroscience, 2019 Two types of reactive astrocytes, A1 and A2 astrocytes, are induced following neuroinflammation and ischemia. In this study, we evaluated the effects of the fibroblast growth factor (FGF)2/FGF receptor (FGFR)1 pathway on A1 and A2 astrocytes in the rat ...
Lin-Hui Zou +8 more
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Homer1 promotes the conversion of A1 astrocytes to A2 astrocytes and improves the recovery of transgenic mice after intracerebral hemorrhage [PDF]
Journal of Neuroinflammation, 2022 Background Inflammation induced by intracerebral hemorrhage (ICH) is one of the main causes of the high mortality and poor prognosis of patients with ICH.
Xiaowei Fei +9 more
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Induced Expression of kir6.2 in A1 Astrocytes Propagates Inflammatory Neurodegeneration via Drp1-dependent Mitochondrial Fission [PDF]
Frontiers in Pharmacology, 2021 Glia-mediated inflammatory processes are crucial in the pathogenesis of Parkinson’s disease (PD). As the most abundant cells of the brain and active participants in neuroinflammatory responses, astrocytes largely propagate inflammatory signals and ...
Nanshan Song +10 more
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Repeated lidocaine exposure induces synaptic and cognitive impairment in aged mice by activating microglia and neurotoxic A1 astrocytes [PDF]
iScienceSummary: In the perioperative setting, the administration of intravenous lidocaine is widespread. This study investigates the effects of varying frequencies of intravenous lidocaine on cognitive function in mice of differing ages.
Xiaohui Chen +9 more
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Molecules, 2023 Highly neurotoxic A1-reactive astrocytes have been associated with several human neurodegenerative diseases. Complement protein C3 expression is strongly upregulated in A1 astrocytes, and this protein has been shown to be a specific biomarker of these ...
Joana Poejo +4 more
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Frontiers in Neuroscience, 2021 After spinal cord injury (SCI), reactive astrocytes can be classified into two distinctive phenotypes according to their different functions: neurotoxic (A1) astrocytes and neuroprotective (A2) astrocytes.
Xuankang Wang +10 more
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Journal of Neuroinflammation, 2021 Background Two activation states of reactive astrocytes termed A1 and A2 subtypes emerge at the lesion sites following spinal cord injury (SCI). A1 astrocytes are known to be neurotoxic that participate in neuropathogenesis, whereas A2 astrocytes have ...
Lilan Li +12 more
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Cell Communication and Signaling, 2023 Background Limited progress in terms of an effective treatment for spinal cord injury (SCI) emphasizes the urgent need for novel therapies. As a vital central nervous system component, the resident astrocytes play crucial roles in regulating recovery ...
Jie Chang +10 more
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Astrocyte polarization in glaucoma: a new opportunity
Neural Regeneration Research, 2022 Astrocyte polarization is a new concept which is similar to microglia polarization and in which astrocytes are classified as A1 (neurotoxic) and A2 (neuroprotective).
Yi-Xin Liu, Hao Sun, Wen-Yi Guo
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