Results 31 to 40 of about 303,232 (214)

GLP-1 Receptor Agonist NLY01 Reduces Retinal Inflammation and Neuron Death Secondary to Ocular Hypertension

Cell Reports, 2020
Summary: Glaucoma is the leading cause of irreversible blindness and is characterized by the death of retinal ganglion cells (RGCs). Recent studies have implicated pro-inflammatory microglia, macrophages, and A1 astrocytes in the pathogenesis of ...
Jacob K. Sterling, Modupe O. Adetunji, Samyuktha Guttha, Albert R. Bargoud, Katherine E. Uyhazi, Ahmara G. Ross, Joshua L. Dunaief, Qi N. Cui   +7 more
doaj   +1 more source

Astrocytic A1/A2 paradigm participates in glycogen mobilization mediated neuroprotection on reperfusion injury after ischemic stroke

Journal of Neuroinflammation, 2021
Background Astrocytic glycogen works as an essential energy reserve for surrounding neurons and is reported to accumulate excessively during cerebral ischemia/reperfusion (I/R) injury.
Haiyun Guo, Ze Fan, Shiquan Wang, Lina Ma, Jin Wang, Doutong Yu, Zhen Zhang, Lin Wu, Zhengwu Peng, Wenming Liu, Wugang Hou, Yanhui Cai   +11 more
doaj   +1 more source

Flow cytometry analysis of immune and glial cells in a trigeminal neuralgia rat model

Scientific Reports, 2021
Microvascular compression of the trigeminal root entry zone (TREZ) is the main cause of most primary trigeminal neuralgia (TN), change of glial plasticity was previously studied in the TREZ of TN rat model induced by chronic compression.
Junjin Lin, Luxi Zhou, Zhaoke Luo, Madeha Ishag Adam, Li Zhao, Feng Wang, Daoshu Luo   +6 more
doaj   +1 more source

Neurotoxic astrocytes express the d-serine synthesizing enzyme, serine racemase, in Alzheimer's disease

Neurobiology of Disease, 2019
Although β-amyloid plaques are a well-recognized hallmark of Alzheimer's disease (AD) neuropathology, no drugs reducing amyloid burden have shown efficacy in clinical trials, suggesting that once AD symptoms emerge, disease progression becomes ...
Darrick T. Balu, Harry Pantazopoulos, Cathy C.Y. Huang, Kevin Muszynski, Theresa Lynn Harvey, Yota Uno, Jacki M. Rorabaugh, Claire R. Galloway, Christian Botz-Zapp, Sabina Berretta, David Weinshenker, Joseph T. Coyle   +11 more
doaj   +1 more source

Complement 3+-astrocytes are highly abundant in prion diseases, but their abolishment led to an accelerated disease course and early dysregulation of microglia

Acta Neuropathologica Communications, 2019
Astrogliosis and activation of microglia are hallmarks of prion diseases in humans and animals. Both were viewed to be rather independent events in disease pathophysiology, with proinflammatory microglia considered to be the potential neurotoxic species ...
Kristin Hartmann, Diego Sepulveda-Falla, Indigo V. L. Rose, Charlotte Madore, Christiane Muth, Jakob Matschke, Oleg Butovsky, Shane Liddelow, Markus Glatzel, Susanne Krasemann   +9 more
doaj   +1 more source

Table_1_Photobiomodulation Promotes Repair Following Spinal Cord Injury by Regulating the Transformation of A1/A2 Reactive Astrocytes.XLSX

, 2021
After spinal cord injury (SCI), reactive astrocytes can be classified into two distinctive phenotypes according to their different functions: neurotoxic (A1) astrocytes and neuroprotective (A2) astrocytes.
Zhiwen Song (704672), Xuankang Wang (11633899), Xin Li (51274), Xueyu Hu (110540), Zhihao Zhang (1605406), Zhijie Zhu (381047), Zhe Wang (41178), Zhuowen Liang (8536353), Cheng Ju (4987847), Xiaoshuang Zuo (11633902)   +9 more
core   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Adenosine-mediated modulation of ventral horn interneurons and spinal motoneurons in neonatal mice [PDF]

, 2015
The authors are grateful for support from the Wellcome Trust.Neuromodulation allows neural networks to adapt to varying environmental and biomechanical demands. Purinergic signalling is known to be an important modulatory system in many parts of the CNS,
Witts, Emily Charlotte, Miles, Gareth Brian, Nascimento, Filipe, Miles, Gareth Brian; id_orcid   +3 more
core   +1 more source

Frequency and Phenotype of Coexisting Aquaporin‐4 and Autoimmune Encephalitis Autoantibodies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Among 9457 aquaporin‐4 (AQP4) immunoglobulin G‐positive patients, 2071 underwent autoimmune encephalitis antibody testing and 85 (4%) had coexisting antibodies, most commonly cerebrospinal fluid glial fibrillary acidic protein‐IgG and N‐methyl‐D‐aspartate receptor‐IgG, or serum high‐titer GAD65‐IgG.
Laura Cacciaguerra, Binxia Yang, Vanda A. Lennon, Shruti P. Agnihotri, Nusrat Ahsan, Karen S. Fernandez, Erin McLeod, Georgios Mangioris, William R. Meador, Wendy G. Mitchell, Jacqueline A. Nicholas, Amy M. L. Quek, Thomas Shoemaker, Kurt Sieloff, Matt C. Edmond, Rebekah A. Laggis, Kristin L. Flynn, Jessica A. Sagen, Emmanuelle Waubant, John J. Chen, Sarosh R. Irani, Andrew McKeon, Anastasia Zekeridou, Eoin P. Flanagan, Sean J. Pittock, Amy Kunchok   +25 more
wiley   +1 more source

Ceria nanoparticles ameliorate white matter injury after intracerebral hemorrhage: microglia-astrocyte involvement in remyelination

Journal of Neuroinflammation, 2021
Background Intracerebral hemorrhage (ICH) can induce excessive accumulation of reactive oxygen species (ROS) that may subsequently cause severe white matter injury.
Jingwei Zheng, Jia’nan Lu, Shuhao Mei, Haijian Wu, Zeyu Sun, Yuanjian Fang, Shenbin Xu, Xiaoyu Wang, Ligen Shi, Weilin Xu, Sheng Chen, Jun Yu, Feng Liang, Jianmin Zhang   +13 more
doaj   +1 more source