Results 21 to 30 of about 303,232 (214)

The effect of A1 and A2 reactive astrocyte expression on hydrocephalus shunt failure

Fluids and Barriers of the CNS, 2022
Background The composition of tissue obstructing neuroprosthetic devices is largely composed of inflammatory cells with a significant astrocyte component.
Fatemeh Khodadadei, Rooshan Arshad, Diego M. Morales, Jacob Gluski, Neena I. Marupudi, James P. McAllister, David D. Limbrick, Carolyn A. Harris   +7 more
doaj   +1 more source

NLRP3 inflammasome regulates astrocyte transformation in brain injury induced by chronic intermittent hypoxia

BMC Neuroscience, 2022
Background Obstructive sleep apnea (OSA) is mainly characterized by sleep fragmentation and chronic intermittent hypoxia (CIH), the latter one being associated with multiple organ injury. Recently, OSA-induced cognition dysfunction has received extensive
Ningning She, Yewen Shi, Yani Feng, Lina Ma, Yuqi Yuan, Yitong Zhang, Zine Cao, Xi Chen, Bingjie Zhao, Haiqin Liu, Xiaoyong Ren   +10 more
doaj   +1 more source

Astrocytes-hNS1 are a pure culture of human astrocytes.

, 2023
hNS-1 cells were differentiated for 21 days. The differentiated cells were harvested and seeded in culture labware without poly-L-lysine treatment and with DMEM.
Edson Iván Rubio-Hernández (14856891), Mauricio Comas-García (14856894), Mayra Colunga-Saucedo (14856900), Miguel Angel Coronado-Ipiña (14856897), Claudia G. Castillo (14856906), Hilda Minerva González Sánchez (14856903)   +5 more
core   +1 more source

Selective Modulation of A1 Astrocytes by Drug-Loaded Nano-Structured Gel In Spinal Cord Injury [PDF]

, 2020
Astrogliosis has a very dynamic response during the progression of spinal cord injury, with beneficial or detrimental effects on recovery. It is therefore important to develop strategies to target activated astrocytes and their harmful molecular ...
Mariani A., De Paola M., Mauri E., Vismara I., Rossi F., Sponchioni M., Affatato R., Moscatelli D., Veglianese P., Forloni G., Veneruso V., Rossetti A., Papa S., Sacchetti A.   +13 more
core   +1 more source

Fluoxetine inhibited the activation of A1 reactive astrocyte in a mouse model of major depressive disorder through astrocytic 5-HT2BR/β-arrestin2 pathway

Journal of Neuroinflammation, 2022
Background Fluoxetine, a selective serotonin reuptake inhibitor, has been reported to directly bind with 5-HT2B receptor (5-HT2BR), but the precise mechanisms, whereby fluoxetine confers the anti-depressive actions via 5-HT2BR is not fully understood ...
Yinquan Fang, Xiao Ding, Yihe Zhang, Lei Cai, Yuan Ge, Kaiyang Ma, Rong Xu, Shanshan Li, Mengmeng Song, Hong Zhu, Jiaqi Liu, Jianhua Ding, Ming Lu, Gang Hu   +13 more
doaj   +1 more source

An update on reactive astrocytes in chronic pain

Journal of Neuroinflammation, 2019
Chronic pain is a critical clinical problem with an increasing prevalence. However, there are limited effective prevention measures and treatments for chronic pain.
Ting Li, Xuhui Chen, Chuanhan Zhang, Yue Zhang, Wenlong Yao   +4 more
doaj   +1 more source

Exocytosis of ATP from astrocytes modulates phasic and tonic inhibition in the neocortex [PDF]

, 2014
Communication between neuronal and glial cells is important for many brain functions. Astrocytes can modulate synaptic strength via Ca2+-stimulated release of various gliotransmitters, including glutamate and ATP. A physiological role of ATP release from
Lalo, Ulyana, Pankratov, Yuriy, Palygin, Oleg, Oleg Palygin (407627), Philip G Haydon, Ulyana Lalo (506296), Yuriy Pankratov, Seyed Rasooli-Nejad (506297), Rasooli-Nejad, Seyed, Yuriy Pankratov (407630), Oleg Palygin, Ulyana Lalo, Haydon, Philip G., Jemma Andrew, Jemma Andrew (506298), Philip G. Haydon (506299), Andrew, Jemma, Seyed Rasooli-Nejad, Pankratov Yuriy, Lalo Ulyana, Andrew Jemma, Palygin Oleg, Rasooli-Nejad Seyed, Haydon Philip G.   +23 more
core   +2 more sources

Osteopontin regulates proliferation, migration, and survival of astrocytes depending on their activation phenotype

, 2021
The glycoprotein osteopontin is highly upregulated in central nervous system (CNS) disorders such as ischemic stroke. Osteopontin regulates cell growth, cell adhesion, homeostasis, migration, and survival of various cell types.
Elena Gross, Rueger, Maria Adele, Monika Rabenstein, Stefan Johannes Blaschke, Gereon Rudolf Fink, Petereit, Helena, Vay, Sabine Ulrike, Rabenstein, Monika, Olschewski, Daniel Navin, Blaschke, Stefan Johannes, Maria Adele Rueger, Felix Lange, Fink, Gereon Rudolf, Schroeter, Michael, Nazarzadeh, Nilufar, Nilufar Nazarzadeh, Sabine Ulrike Vay, Lange, Felix, Gross, Elena, Michael Schroeter, Daniel Navin Olschewski, Helena Petereit   +21 more
core   +1 more source

Roles of neuropathology-associated reactive astrocytes: a systematic review

Acta Neuropathologica Communications, 2023
In the contexts of aging, injury, or neuroinflammation, activated microglia signaling with TNF-α, IL-1α, and C1q induces a neurotoxic astrocytic phenotype, classified as A1, A1-like, or neuroinflammatory reactive astrocytes.
Jill M. Lawrence, Kayla Schardien, Brian Wigdahl, Michael R. Nonnemacher   +3 more
doaj   +1 more source

P2X1 and P2X5 subunits form the functional P2X receptor in mouse cortical astrocytes [PDF]

, 2008
ATP plays an important role in signal transduction between neuronal and glial circuits and within glial networks. Here we describe currents activated by ATP in astrocytes acutely isolated from cortical brain slices by non-enzymatic mechanical ...
Lalo, Ulyana, Pankratov, Yuriy, Verkhratsky, A. N. (Alekseĭ Nestorovich), Wichert, S., Kirchhoff, F., Rossner, Moritz J., Verkhratsky, Alexei; id_orcid, Kirchhoff, Frank, Verkhratsky, Alexei, Pankratov, Y., Rossner, M., Lalo, U., Verkhratskiĭ, A. N. (Alekseĭ Nestorovich), North, R., Pankratov, Yuri, North, R. Alan, Verkhratsky, A., Wichert, Sven P.   +17 more
core   +1 more source