Results 11 to 20 of about 303,232 (214)

Mesenchymal Stem Cell-Derived Exosomes Reduce A1 Astrocytes via Downregulation of Phosphorylated NFκB P65 Subunit in Spinal Cord Injury [PDF]

Cellular Physiology and Biochemistry, 2018
Background/Aims: Neurotoxic A1 astrocytes are induced by inflammation after spinal cord injury (SCI), and the inflammation-related Nuclear Factor Kappa B (NFκB) pathway may be related to A1-astrocyte activation.
Lin Wang, Shuang Pei, Linlin Han, Bin Guo, Yanfei Li, Ranran Duan, Yaobing Yao, Bohan Xue, Xuemei Chen, Yanjie Jia   +9 more
doaj   +2 more sources

The EIF2α-PERK Signaling Pathway Mediates Manganese Exposure-Induced A1-Type Astrocytes Activation via Endoplasmic Reticulum Stress

Toxics
Elevated exposure to manganese (Mn) has been linked to a broad spectrum of neurological disorders, including motor dysfunction. Neuroinflammation with excessively activated astrocytes plays a critical role in the pathogenesis and progression of ...
Jing Wang, Tingting Guo, Yang Hu, Congcong Zhuang, Peng Su, Xinqin Liu   +5 more
doaj   +2 more sources

Kynurenic acid blunts A1 astrocyte activation against neurodegeneration in HIV-associated neurocognitive disorders

Journal of Neuroinflammation, 2023
Despite extensive astrocyte activation in patients suffering from HIV-associated neurocognitive disorders (HAND), little is known about the contribution of astrocytes to HAND neuropathology.
Jingxian Lun, Yubin Li, Xuefeng Gao, Zelong Gong, Xiaoliang Chen, Jinhu Zou, Chengxing Zhou, Yuanyuan Huang, Bingliang Zhou, Pengwei Huang, Hong Cao   +10 more
doaj   +2 more sources

Blocking Notch signal pathway suppresses the activation of neurotoxic A1 astrocytes after spinal cord injury. [PDF]

Cell Cycle, 2019
Spinal cord injury (SCI) is a catastrophic disease which has complicated pathogenesis including inflammation, oxidative stress and glial scar formation.
Qian D, Li L, Rong Y, Liu W, Wang Q, Zhou Z, Gu C, Huang Y, Zhao X, Chen J, Fan J, Yin G.   +11 more
europepmc   +2 more sources

Markers of A1 astrocytes stratify to molecular sub-types in sporadic Creutzfeldt-Jakob disease brain. [PDF]

Brain Commun, 2020
Astrocytes are glial cells of the central nervous system that become reactive under conditions of stress. The functional properties of reactive astrocytes depend on their stimulus that induces the upregulation of specific genes. Reactive astrocytes are a
Ugalde CL, Lewis V, Stehmann C, McLean CA, Lawson VA, Collins SJ, Hill AF.   +6 more
europepmc   +2 more sources

Early Reactive A1 Astrocytes Induction by the Neurotoxin 3-Nitropropionic Acid in Rat Brain. [PDF]

Int J Mol Sci, 2020
3-Nitropropionic acid (NPA) administration to rodents produces degeneration of the striatum, accompanied by neurological disturbances that mimic Huntington’s disease (HD) motor neurological dysfunctions. It has been shown that inflammation mediates
Lopez-Sanchez C, Garcia-Martinez V, Poejo J, Garcia-Lopez V, Salazar J, Gutierrez-Merino C.   +5 more
europepmc   +2 more sources

Modulation of GPER1 alleviates early brain injury via inhibition of A1 reactive astrocytes activation after intracerebral hemorrhage in mice

Heliyon
Background: Early brain injury (EBI) caused by inflammatory responses in acute phase of Intracerebral hemorrhage (ICH) plays a vital role in the pathological progression of ICH.
Jianchao Mao, Yongkun Guo, Huanhuan Li, Hongfei Ge, Chao Zhang, Hua Feng, Jun Zhong, Rong Hu, Xinjun Wang   +8 more
doaj   +2 more sources

Study on the Polarization of Astrocytes in the Optic Nerve Head of Rats Under High Intraocular Pressure: In Vitro

Bioengineering
Astrocytes, the most common glial cells in the optic nerve head (ONH), provide support and nutrition to retinal ganglion cells. This study aims to investigate the polarization types of astrocytes in the ONH of rats under high intraocular pressure (IOP ...
Bochao Ma, Jifeng Ren, Xiuqing Qian
doaj   +2 more sources

Microglia induce the transformation of A1/A2 reactive astrocytes via the CXCR7/PI3K/Akt pathway in chronic post-surgical pain

Journal of Neuroinflammation, 2020
Background Activated astrocytes play important roles in chronic post-surgical pain (CPSP). Recent studies have shown reactive astrocytes are classified into A1 and A2 phenotypes, but their precise roles in CPSP remain unknown.
Ting Li, Tongtong Liu, Xuhui Chen, Li Li, Miaomiao Feng, Yue Zhang, Li Wan, Chuanhan Zhang, Wenlong Yao   +8 more
doaj   +1 more source

The critical role of KLF4 in regulating the activation of A1/A2 reactive astrocytes following ischemic stroke

Journal of Neuroinflammation, 2023
Background We have previously demonstrated that the expression of kruppel-like transcription factor-4 (KLF-4) is upregulated in astrocytes following acute ischemic stroke (AIS) and found that KLF4 confers vascular protection against cerebral ischemic ...
Cong Wang, Longxuan Li
doaj   +1 more source