Results 21 to 30 of about 1,824,086 (180)

Intravitreal Neuroglobin Mitigates Primate Experimental Glaucomatous Structural Damage in Association with Reduced Optic Nerve Microglial and Complement 3-Astrocyte Activation

Biomolecules, 2023
Current management of glaucomatous optic neuropathy is limited to intraocular pressure control. Neuroglobin (Ngb) is an endogenous neuroprotectant expressed in neurons and astrocytes.
Anita S. Y. Chan, Sai B. B. Tun, Myoe N. Lynn, Candice Ho, Tin A. Tun, Michaël J. A. Girard, Rehena Sultana, Veluchamy A. Barathi, Tin Aung, Makoto Aihara   +9 more
doaj   +1 more source

TGF-beta(2)- and H2O2-Induced Biological Changes in Optic Nerve Head Astrocytes Are Reduced by the Antioxidant Alpha-Lipoic Acid [PDF]

, 2012
Background/Aims: The goal of the present study was to determine whether transforming growth factor-beta(2) (TGF-beta(2))- and oxidative stress-induced cellular changes in cultured human optic nerve head (ONH) astrocytes could be reduced by pretreatment ...
Yu, Alice L., Welge-Lussen, Ulrich, Moriniere, Jerome   +2 more
core   +1 more source

Smarcc1 drives optic stalk patterning and optic nerve head astrocyte differentiation. [PDF]

Development
The optic nerve develops from the neuroectodermal optic stalk, which undergoes coordinated morphogenesis and gives rise to optic nerve astrocytes that support retinal ganglion cell axons.
Zuk-Bar N, Ovadia S, Cui G, Obolensky A, Banin E, Ofri R, Jing N, Ashery-Padan R.   +7 more
europepmc   +2 more sources

Effects of glutamate receptor activation on NG2-glia in the rat optic nerve [PDF]

, 2009
NG2-glia are a substantial population of cells in the central nervous system (CNS) that can be identified by their specific expression of the NG2 chondroitin sulphate (CSPG).
Hubbard, Paul S., Hamilton, Nicola; id_orcid, Hamilton, N., Butt, Arthur, Hubbard, Paul, Butt, Arthur M., Hamilton, N, Hubbard, P., Butt, AM   +8 more
core   +1 more source

Neurolin expression in the optic nerve and immunoreactivity of Pax6-positive niches in the brain of rainbow trout (Oncorhynchus mykiss) after unilateral eye injury

Neural Regeneration Research, 2019
In contrast to astrocytes in mammals, fish astrocytes promote axon regeneration after brain injury and actively participate in the regeneration process. Neurolin, a regeneration-associated, Zn8-labeled protein, is involved in the repair of damaged optic ...
Evgeniya V Pushchina, Anatoly A Varaksin
doaj   +1 more source

The Time Course of Gene Expression during Reactive Gliosis in the Optic Nerve. [PDF]

PLoS ONE, 2013
Reactive gliosis is a complex process that involves changes in gene expression and morphological remodeling. The mouse optic nerve, where astrocytes, microglia and oligodendrocytes interact with retinal ganglion cell axons and each other, is a ...
Juan Qu, Tatjana C Jakobs
doaj   +1 more source

Mechanobiological responses of astrocytes in optic nerve head due to biaxial stretch

BMC Ophthalmology, 2022
Background Elevated intraocular pressure (IOP) is the main risk factor for glaucoma, which might cause the activation of astrocytes in optic nerve head. To determine the effect of mechanical stretch on the astrocytes, we investigated the changes in cell ...
Zhiwen Li, Fan Peng, Zhicheng Liu, Shanshan Li, Lin Li, Xiuqing Qian   +5 more
doaj   +1 more source

Comparative evaluation of methods for estimating retinal ganglion cell loss in retinal sections and wholemounts. [PDF]

PLoS ONE, 2014
To investigate the reliability of different methods of quantifying retinal ganglion cells (RGCs) in rat retinal sections and wholemounts from eyes with either intact optic nerves or those axotomised after optic nerve crush (ONC).
Ben Mead, Adam Thompson, Ben A Scheven, Ann Logan, Martin Berry, Wendy Leadbeater   +5 more
doaj   +1 more source

Chronic Histological Outcomes of Indirect Traumatic Optic Neuropathy in Adolescent Mice: Persistent Degeneration and Temporally Regulated Glial Responses

Cells, 2021
Injury to the optic nerve, termed, traumatic optic neuropathy (TON) is a known comorbidity of traumatic brain injury (TBI) and is now known to cause chronic and progressive retinal thinning up to 35 years after injury.
Shelby M. Hetzer, Emily M. Shalosky, Jordyn N. Torrens, Nathan K. Evanson   +3 more
doaj   +1 more source

Characterization of Pax2 expression in the goldfish optic nerve head during retina regeneration. [PDF]

PLoS ONE, 2012
The Pax2 transcription factor plays a crucial role in axon-guidance and astrocyte differentiation in the optic nerve head (ONH) during vertebrate visual system development. However, little is known about its function during regeneration.
Marta Parrilla, Concepción Lillo, M Javier Herrero-Turrión, Rosario Arévalo, José Aijón, Juan M Lara, Almudena Velasco   +6 more
doaj   +1 more source