Results 91 to 100 of about 183,318 (235)

Retinal thinning differentiates treatment effects in relapsing multiple sclerosis below the clinical threshold

Annals of Clinical and Translational Neurology, Volume 12, Issue 2, Page 345-354, February 2025.
Abstract Objective To investigate retinal layer thinning as a biomarker of disease‐modifying treatment (DMT) effects in relapsing multiple sclerosis (RMS). Methods From an ongoing prospective observational study, we included patients with RMS, who (i) had an optical coherence tomography (OCT) scan within 6 to 12 months after DMT start (rebaseline) and ≥
Gabriel Bsteh, Harald Hegen, Nik Krajnc, Fabian Föttinger, Patrick Altmann, Michael Auer, Klaus Berek, Barbara Kornek, Fritz Leutmezer, Stefan Macher, Tobias Monschein, Markus Ponleitner, Paulus Rommer, Christiane Schmied, Karin Zebenholzer, Gudrun Zulehner, Tobias Zrzavy, Florian Deisenhammer, Franziska Di Pauli, Berthold Pemp, Thomas Berger   +20 more
wiley   +1 more source

Optic Disc and Cup Segmentation Methods for Glaucoma Detection with Modification of U-Net Convolutional Neural Network [PDF]

, 2017
Glaucoma is the second leading cause of blindness all over the world, with approximately 60 million cases reported worldwide in 2010. If undiagnosed in time, glaucoma causes irreversible damage to the optic nerve leading to blindness. The optic nerve head examination, which involves measurement of cup-to-disc ratio, is considered one of the most ...
arxiv   +1 more source

The 3D Structural Phenotype of the Glaucomatous Optic Nerve Head and its Relationship with The Severity of Visual Field Damage [PDF]

arXiv, 2023
$\bf{Purpose}$: To describe the 3D structural changes in both connective and neural tissues of the optic nerve head (ONH) that occur concurrently at different stages of glaucoma using traditional and AI-driven approaches. $\bf{Methods}$: We included 213 normal, 204 mild glaucoma (mean deviation [MD] $\ge$ -6.00 dB), 118 moderate glaucoma (MD of -6.01
arxiv  

Enhanced Depth Imaging Optical Coherence Tomography of Optic Nerve Head Drusen: A Comparison of Cases with and without Visual Field Loss [PDF]

, 2017
PURPOSE: Enhanced depth imaging (EDI) spectral-domain optical coherence tomography (SD OCT) has been recognized as the most sensitive tool to diagnose optic nerve head drusen (ONHD).
Keane, PA, Plant, GT, Sabah, M, Traber, GL, Weber, KP   +4 more
core  

Seven Novel Variants of Weiss‐Kruszka Syndrome and Phenotype Expansion

American Journal of Medical Genetics Part A, Volume 197, Issue 2, February 2025.
ABSTRACT Weiss‐Kruszka syndrome (WKS) is a rare genetic disorder characterized by metopic ridging, ptosis, arched eyebrows, down slanting palpebral fissures, abnormalities in the corpus callosum, cardiac malformations, and variable neurodevelopmental delay. To date, 32 individuals with a diagnosis of WKS have been reported in the literature.
Anna Hau, Anne Baxter, Kate Chandler, Andrew Fennell, Tzung‐Chien Hsieh, Peter M. Krawitz, Jason Pinner, Himanshu Goel   +7 more
wiley   +1 more source

Trends and Clinical Characteristics of Pediatric Patients Presenting to an Ophthalmology Emergency Department with an Initial Diagnosis of Optic Nerve Head Elevation

Clinical Ophthalmology, 2022
Kara M Cavuoto, Zahra Markatia, Annika Patel, Carla J Osigian Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USACorrespondence: Kara M Cavuoto, Department of Ophthalmology, Bascom ...
Cavuoto KM, Markatia Z, Patel A, Osigian CJ   +3 more
doaj  

Clinical Findings and Optical Coherence Tomography Measurements of Pediatric Patients with Papilledema and Pseudopapilledema

Türk Oftalmoloji Dergisi, 2023
Objectives:To compare the clinical findings and multimodal imaging of pediatric patients diagnosed with papilledema and pseudopapilledema with those of healthy individuals.Materials and Methods:Ninety children (
Ayşin Tuba Kaplan, Sibel Öskan Yalçın, Safiye Güneş Sağer   +2 more
doaj   +1 more source

AnatomyNet: Deep Learning for Fast and Fully Automated Whole-volume Segmentation of Head and Neck Anatomy [PDF]

, 2018
Methods: Our deep learning model, called AnatomyNet, segments OARs from head and neck CT images in an end-to-end fashion, receiving whole-volume HaN CT images as input and generating masks of all OARs of interest in one shot. AnatomyNet is built upon the popular 3D U-net architecture, but extends it in three important ways: 1) a new encoding scheme to ...
arxiv   +1 more source

Diagnosis of papilledema and pseudopapilledema using optical coherence tomography [PDF]

, 2022
Background: Papilledema is a common clinical problem where the ophthalmologist plays an important role in its diagnosis. Optical coherence tomography (OCT) provides high resolution images of the retina and the retinal nerve fiber layer (RNFL).Objective ...
Al-Nashar, Haitham Younis, Elmenezaa, Ahmed Gamal Ahmed, Fawzy, Khaled Mohamed, Nasr, Abdullah Ahmed Hassan   +3 more
core   +1 more source

Retinal dysfunction in APOE4 knock‐in mouse model of Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue 2, February 2025.
Graphical summary of retinal dysfunction in APOE4 knock‐in (KI) mice aged 5257 weeks. The model exhibits vascular deficits (increased vascular tortuosity), behavioral dysfunction (decreased visual acuity and contrast sensitivity), and neuronal deficits (impaired retinal function, bipolar cell stunting, and loss of photoreceptors).
Surabhi D. Abhyankar, Qianyi Luo, Gabriella D. Hartman, Neha Mahajan, Timothy W. Corson, Adrian L. Oblak, Bruce T. Lamb, Ashay D. Bhatwadekar   +7 more
wiley   +1 more source