Results 91 to 100 of about 4,751 (169)

Activated mTOR Signaling in the RPE Drives EMT, Autophagy, and Metabolic Disruption, Resulting in AMD‐Like Pathology in Mice

Aging Cell, Volume 24, Issue 6, June 2025.
Our study reveals that overactivation of both mTOR complexes through mLST8 in RPE cells triggers AMD‐like pathology and cellular dysfunction. This finding highlights the critical role of balanced mTOR signaling in retinal health and suggests that targeting both complexes could be therapeutic for AMD treatment.
Olivia Chowdhury, Sridhar Bammidi, Pooja Gautam, Vishnu Suresh Babu, Haitao Liu, Peng Shang, Ying Xin, Emma Mahally, Mihir Nemani, Victoria Koontz, Kira Lathrop, Katarzyna M. Kedziora, Jonathan Franks, Ming Sun, Joshua W. Smith, Lauren R. DeVine, Robert N. Cole, Nadezda Stepicheva, Anastasia Strizhakova, Sreya Chattopadhyay, Stacey Hose, Jacob Samuel Zigler Jr., José‐Alain Sahel, Jiang Qian, Prasun Guha, James T. Handa, Sayan Ghosh, Debasish Sinha   +27 more
wiley   +1 more source

The role and therapeutic potential of melatonin in age-related ocular diseases [PDF]

, 2017
The eye is continuously exposed to solar UV radiation and pollutants, making it prone to oxidative attacks. In fact, oxidative damage is a major cause of age-related ocular diseases including cataract, glaucoma, age-related macular degeneration and ...
Colligris, Basilio, Crooke, Almudena, Huete Toral, Fernando, Pintor, Jesús   +3 more
core   +2 more sources

Do Optic Disc Drusen Cause Unilateral Nyctalopia

Case Reports in Ophthalmology, 2010
This is a case report of a patient with unilateral nyctalopia in whom ipsilateral optic disc drusen were the only finding despite extensive investigation.
Yi Wei Goh, Alex Buller
doaj   +1 more source

Visual Field Defects in Patients With Optic Nerve Head Drusen. [PDF]

Cureus, 2023
Viana AR, Pereira S, Lemos A, Basto R, Correia Barbosa R, Reis da Silva A.   +5 more
europepmc   +1 more source

Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis. [PDF]

, 2015
The degradation of phagosomes, derived from the ingestion of photoreceptor outer segment (POS) disk membranes, is a major role of the retinal pigment epithelium (RPE). Here, POS phagosomes were observed to associate with myosin-7a, and then kinesin-1, as
Diemer, Tanja, Esteve-Rudd, Julian, Jiang, Mei, Lillo, Concepción, Lopes, Vanda S, Rump, Agrani, Williams, David S   +6 more
core   +1 more source

The effects of ocular magnification on Spectralis spectral domain optical coherence tomography scan length [PDF]

, 2015
Purpose The purpose of this study was to assess the effects of incorporating individual ocular biometry measures of corneal curvature, refractive error, and axial length on scan length obtained using Spectralis spectral domain optical coherence ...
A Sanchez-Cano, AG Bennett, AKC Lam, AR Rudnicka, Byki Huntjens, CK Leung, CK Leung, CV Regatieri, D Huang, D Odell, DF Garway-Heath, EM Anger, F Mojana, FA Folgar, FM Rauscher, G Savini, H Song, Irene Ctori, J Moreno-Montañés, J Oh, JC Tan, JM Nolan, K Pesudovs, LA Paunescu, M Wagner-Schuman, ML Kirby, MN Menke, MS Almeida, N Nassif, N Visser, NB Patel, P Carpineto, PK Verkicharla, S Bayraktar, S Lee, S Ooto, SJ Chiu, Stephen Gruppetta, T Röck, U Chakravarthy, Y Wakitani   +40 more
core   +1 more source

Enhancing the knowledge in fundus autofluorescence of optic nerve head drusen assessed with broad line fundus imaging technology. [PDF]

GMS Ophthalmol Cases, 2023
Barbosa GCS, Zacharias LC, Novais EA, Guerra RLL.   +3 more
europepmc   +1 more source

Functional deficits precede structural lesions in mice with high-fat diet-induced diabetic retinopathy [PDF]

, 2016
Obesity predisposes to human type 2 diabetes, the most common cause of diabetic retinopathy. To determine if high-fat diet–induced diabetes in mice can model retinal disease, we weaned mice to chow or a high-fat diet and tested the hypothesis that diet ...
Bligard, Gregory W, Lukasiewicz, Peter, Rajagopal, Rithwick, Semenkovich, Clay F, Yin, Li, Zhang, Sheng   +5 more
core   +2 more sources

Quantitative Optical Coherence Tomography Angiography of Choroidal Neovascularization in Age-Related Macular Degeneration [PDF]

, 2014
Purpose To detect and quantify choroidal neovascularization (CNV) in patients with age-related macular degeneration (AMD) using optical coherence tomography (OCT) angiography. Design Observational, cross-sectional study.
Bailey, Steven T., Flaxel, Christina J., Fujimoto, James G., Huang, David, Jia, Yali, Klein, Michael L., Kraus, Martin F., Liu, Jonathan Jaoshin, Lu, Chen David, Potsaid, Benjamin M., Tan, Ou, Wilson, David J.   +11 more
core   +1 more source

Bilateral Optic Disc Drusen in an Adolescent Female: A Case Report

Nigerian Journal of Medicine
Optic disc drusen (ODD) are calcified deposits within the optic nerve head, usually buried and uncalcified in young patients, and present as pseudopapilloedema, therefore, posing a diagnostic challenge.
Mary Oheobe Ugalahi, Oluwole Iyiola Majekodunmi, Steve Oluwaseun Adebusoye, Tunji Sunday Oluleye   +3 more
doaj   +1 more source