Results 151 to 160 of about 1,469,459 (252)

BioEdge-RGC: Compact Neural Policy Transfer from Model-Predictive Control in a Transcriptomics-Informed Optic Nerve Injury Simulation. [PDF]

Brain Sci
Iancu RI, Eva L, Buzea CG, Nedeff F, Nedeff V, Mirilă D, Panainte-Lehaduș M, Agop M, Grădinaru I, Iancu DPT.   +9 more
europepmc   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Lifestyle Modify Optic Nerve Injury in Mendelian Randomization. [PDF]

Genet Res (Camb)
Zhou M, Shangguan Y, Liu X.
europepmc   +1 more source

Retinal transcriptome of neonatal mice after optic nerve injury. [PDF]

PLoS One, 2023
Yao SQ, Wang M, Liang JJ, Ng TK, Cen LP.
europepmc   +1 more source

Retrolaminar Optic Nerve Enhancement on Orbital MRI in Leber\u27s Hereditary Optic Neuropathy: Clinical and Pathophysiologic Implications

, 2002
To determine whether Leber\u27s hereditary optic neuropathy (LHON) is associated with acute injury to there trolaminar optic ...
Michael S. Vaphiades, DO; Paul H. Phillips, MD
core  

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Experimental upregulation of Lancl1 promotes axon regeneration after optic nerve injury in vivo. [PDF]

Exp Neurol
Lukomska A, Frost MP, Brady J, Kearney A, Balaji AJ, D'Souza C, Trakhtenberg EF.   +6 more
europepmc   +1 more source

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

Advanced Science, EarlyView.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang, Bing‐Jie Tang, Jia‐Yi Li, Shu‐Lan Xie, Shumin Duan, Junping Chen, Shengmei Zhu, Zhen‐Zhong Xu   +7 more
wiley   +1 more source

Multi-genomics data mining identified critical transcription factors and immune response pathways in traumatic optic nerve injury and retinal injury. [PDF]

Front Ophthalmol (Lausanne)
Li J, Zhang Y, Zhou S.
europepmc   +1 more source

Machine Learning‐Driven Design of Multicomponent Bone Inorganic Matrix Mimicking Scaffolds for Osteogenesis Enhanced by Neurogenesis

Advanced Science, EarlyView.
Schematic illustration of development of experimental datasets and algorithm models, screening and preparation of the scaffolds and their applications in vivo. ABSTRACT Bone defects require materials with osteogenic, neurogenic, and angiogenic activity, yet designing such materials within high‐dimensional compositional spaces remains challenging. Here,
Kunlu Lin, Ying Yang, Chuyao Zhou, Hanyue Mao, Zhiquan Zhang, Libangxi Liu, Xiaoying Yu, Haoming Liu, Long Liu, Xiaoyan Wang   +9 more
wiley   +1 more source