Results 81 to 90 of about 1,411,173 (257)

In Situ Photo‑Crosslinked Functional Bilayer Hydrogel Modulates Local Microenvironment and Remyelination After Optic Nerve Injury

Advanced Science, EarlyView.
A blue‐light‐crosslinked bilayer hydrogel was developed for local optic nerve repair. The adhesive GM‐Odex outer layer seals and anchors the lesion, while the non‐adhesive GM‐imid inner layer releases MPDA‐Cle without obstructing CSF flow. This system modulates oxidative and inflammatory microenvironments, supports oligodendrocyte differentiation and ...
Tonghe Pan, Yate Huang, Junhao Zhang, Shudong Tian, Zhixing Li, Xuanwen Li, Yanchen Zhang, Dongmei Wang, Sihao Ye, Ming Jin, Neng Ling, Wentao Yan, Kaihui Nan, Wencan Wu   +13 more
wiley   +1 more source

3D Bioprinted Blood–Brain–Tumor Barrier Spheroid‐Based In Situ Evaluation of Anticancer Compounds Against Glioblastoma: ROS‐Producing Ruthenium as a Potential Therapeutic Candidate

Advanced Science, EarlyView.
The blood–brain–tumor barrier (BBTB) penetration by anticancer drugs and their effects on glioblastoma (GBM) is assessed using 3D bioprinted‐spheroids. Anticancer drug‐induced U‐87 MG cell death is quantified through in situ imaging of spheroids using a cancer cell death probe. The Ru compound, a partial P‐gp substrate, induces greater tumor‐cell death
Hyunjung Lee, Chan Ho Jeon, Doyun Kim, Minjae Lee, Minji Kwon, Joon Myong Song   +5 more
wiley   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

Cervical Hyperextension Causes Acute Cerebral Congestion in Non-Anesthetized Healthy Adults: An Observational Self-Controlled Design Study

Medicina
Background and Objectives: Severe complications associated with cervical hyperextension during general anesthesia have been reported. The question is whether some of the cerebral/spinal ischemic complications could be partially related to the position ...
Ozlem Ersoy Karka, Derya Guclu, Ilknur S. Yorulmaz, Mehmet A. Sungur, Gizem Demir Senoglu, Gulbin Sezen, Yavuz Demiraran   +6 more
doaj   +1 more source

Optic nerve sheath meningocele

, 2018
Musleh Algarni,1,2 Pejman J Maralani,3 Arun NE Sundaram1 1Department of Ophthalmology and Vision Sciences, Sunnybrook Health Sciences Center, University of Toronto, Toronto, ON, Canada; 2Department of Medicine, Al Thagher General Hospital, Jeddah, Saudi ...
Algarni M, Maralani PJ, Sundaram ANE
core  

A Novel Bioactive Component, Efoba, From Aged Garlic Targets CTSC to Suppress NET‐Driven Neuroinflammation and Ameliorate Secondary Brain Injury After Intracerebral Hemorrhage

Advanced Science, EarlyView.
Efoba, a novel bioactive component derived from aged garlic, confers neuroprotection against intracerebral hemorrhage. It acts on microglia to suppress CTSC release, inhibits NET‐mediated neural injury, and blocks pathological microglia‐neutrophil crosstalk. This study provides a highly promising lead compound for hemorrhagic‐stroke therapy.
Junjun Meng, Jianhua Wang, Tao Zhang, Xiaofan Fan, Jinxiu Guo, Shiyuan Zhao, Wenxue Sun, Pei Jiang   +7 more
wiley   +1 more source

Value of Optic Nerve Sheath Diameter in Diagnosis and Follow Up of Patients with Disturbed Conscious Level

Eye and Brain, 2022
Osama Mahmoud Momtaz,1 Omar M Said,2 Amany Mahmoud Mohamed,1 Tamer Sayed Abdel Mawla1 1Critical Care Department, Fayoum University, Fayoum, Egypt; 2Ophthalmology Department, Fayoum University, Fayoum, EgyptCorrespondence: Omar M Said, Ophthalmology ...
Momtaz OM, Said OM, Mohamed AM, Abdel Mawla TS   +3 more
doaj  

Measurement of Optic Nerve Sheath Diameter: Differences between Methods? A Pilot Study

, 2015
Background: Quantification of the optic nerve sheath diameter is a promising approach for the detection of elevated intracranial pressure. The comparability of current methods is unclear. The objective of this study was to assess the relationship between
Holzmann, D, Eisenack, J, Sturm, V, Killer, H E, Landau, K, Giger-Tobler, C, Jaggi, G P, Pangalu, A, Killer HE, Jaggi GP, Pangalu A, Eisenack J, Giger-Tobler C, Landau K, Holzmann D, Sturm V   +15 more
core   +1 more source

Decoupling Quasi‐Solid‐State Sulfur Conversion Mechanisms in Weakly Solvating and Locally High Concentration Electrolytes

Advanced Energy Materials, EarlyView.
Weakly solvating CME–TTE and localized high‐concentration G2–TTE electrolytes redirect lithium–sulfur chemistry toward quasi‐solid‐state conversion through distinct coordination environments. Molecular dynamics and multimodal electrochemical and spectroscopic measurements show that G2–TTE couples multidentate solvent coordination, anion participation ...
Boyi Pang, Huanxin Li, Liam Bird, Yiming Guo, Bochen Li, Xiaoxia Guo, Roby Soni, Yi Zeng, Paul R. Shearing, Thomas S. Miller, Rhodri Jervis, Alexander J. Kibler, James B. Robinson   +12 more
wiley   +1 more source

Thermally Drawn Bioelectric Catheters: Enabling Proprioceptive Endovascular Navigation

Advanced Intelligent Systems, EarlyView.
This work introduces a novel bioelectric navigation system eliminates the need for harmful fluoroscopy during endovascular surgeries. A bespoke 16‐electrode catheter is fabricated using rapid thermal drawing and laser micro‐machining. Paired with a real‐time tracking algorithm fusing vascular geometry detection and distance estimation, this technology ...
Alex Ranne, Heiko Maier, Jinshi Zhao, Songli Moey, Ayhan Aktas, Manik Chana, Burak Temelkuran, Nassir Navab, Ferdinando Rodriguez y Baena   +8 more
wiley   +1 more source