Results 111 to 120 of about 347,881 (287)
Humanized Mouse Models for Type 1 Diabetes
Current Protocols, Volume 5, Issue 10, October 2025.Abstract T cell–mediated autoimmune type 1 diabetes (T1D) is under complex polygenic control in both humans and the NOD mouse model. However, in both species, particular major histocompatibility complex (MHC; designated HLA in humans) haplotypes provide the primary T1D risk factor. Both MHC/HLA class I and II variants interactively contribute to T1D by
David V. Serreze +2 more
wiley +1 more source
Arquivos de Neuro-Psiquiatria, 2013 Objective It was to investigate visual field (VF) abnormalities in a group of multiple sclerosis (MS) patients in the remission phase and the presence of magnetic resonance imaging (MRI) lesions in the optic radiations.
Stella Maris Costa Castro +6 more
doaj +1 more source
A Paper ON "OPTIC NEURITIS," "CHOKED DISC," OR "PAPILLOEDEMA": TREATMENT, LOCALIZING VALUE, AND PATHOLOGY: Delivered before the Section of Ophthalmology of the British Medical Association at Belfast [PDF]
, 1910 Victor Horsley
openalex +1 more source
Update on pediatric optic neuritis.
Current Opinion in Ophthalmology, 2019 PURPOSE OF REVIEW To summarize recent developments in the classification, investigation and management of pediatric optic neuritis (PON). RECENT FINDINGS A recent surge in interest surrounding antibodies to myelin oligodendrocyte glycoprotein antibody (
Jane H Lock +3 more
semanticscholar +1 more source
Journal of Medical Virology, Volume 97, Issue 10, October 2025.ABSTRACT Dengue virus (DENV) is a major arthropod‐borne pathogen, endemic in over 100 countries and posing global health challenges. While innate immune responses and viral evasion mechanisms have been extensively studied in animal models and mononuclear cells, severe dengue can affect multiple tissues, including the central nervous system (CNS ...
Leandro Mantovani de Castro +10 more
wiley +1 more source
LVIII. Monocular Retrobulbar Optic Neuritis Caused by Purulent Maxillary Sinusitis [PDF]
, 1921 J. W. Jervey
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Aging Cell, Volume 24, Issue 10, October 2025.MAPT accumulation inhibited CHMP4B expression and thus disrupted ESCRT‐III‐mediated autophagosome‐lysosome fusion, which induced a vicious cycle between MAPT aggregation and autophagic deficits. Aerobic exercise could effectively block the vicious cycle and reverse autophagic deficits by promoting the β2‐AR‐RXRα‐CHMP4B‐ESCRT‐III pathway, reducing ...
Shu‐Guang Bi +12 more
wiley +1 more source
CNS Neuroscience &Therapeutics, Volume 31, Issue 10, October 2025.Lymphoplasmapheresis (LPE) may potentially represent a promising therapeutic approach for AQP4‐Ab+ NMOSD patients, particularly those with an inadequate response to glucocorticoid therapy. LPE appears to exert a comprehensive effect by modulating immune cell subsets, reducing inflammation, and lowering antibody titers.
Qiuming Zeng +16 more
wiley +1 more source