Results 31 to 40 of about 10,950 (228)

Clinical profile and short-term outcomes of optic neuritis patients in India

Indian Journal of Ophthalmology, 2014
Purpose: To evaluate the clinical profile and short-term visual outcome of optic neuritis (ON) patients in India. Materials and Methods: In this prospective study carried out over a period of 3 years, 99 eyes of 83 ON patients were examined and followed ...
Rohit Saxena, Swati Phuljhele, Vimla Menon, Shailesh Gadaginamath, Ankur Sinha, Pradeep Sharma   +5 more
doaj   +1 more source

Oral lipoic acid as a treatment for acute optic neuritis: a blinded, placebo controlled randomized trial

Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2019
Background Lipoic acid, an antioxidant, has beneficial effects in experimental acute optic neuritis and autoimmune encephalomyelitis. Optical coherence tomography can detect retinal nerve fiber layer thinning, representing axonal degeneration ...
Julie Falardeau, Allison Fryman, Rohan Wanchu, Gail H Marracci, Michele Mass, Lindsey Wooliscroft, Dennis N Bourdette, Charles F Murchison, William L Hills, Vijayshree Yadav   +9 more
doaj   +1 more source

Cell-specific and region-specific transcriptomics in the multiple sclerosis model: Focus on astrocytes. [PDF]

, 2017
Changes in gene expression that occur across the central nervous system (CNS) during neurological diseases do not address the heterogeneity of cell types from one CNS region to another and are complicated by alterations in cellular composition during ...
Ao, Yan, Burda, Josh, Farkhondeh, Vista, Itoh, Noriko, Itoh, Yuichiro, Johnsonbaugh, Hadley, Kaito, Max, Ohno, Ai, Ren, Emily, Sofroniew, Michael V, Tassoni, Alessia, Voskuhl, Rhonda R   +11 more
core   +2 more sources

The Optic Neuritis Treatment Trial [PDF]

Archives of Ophthalmology, 2008
T HE OPTIC NEURITIS TREATMENT TRIAL (ONTT)hashadahighly significant impact on thepracticesofophthalmologyandneurology. The impact can be attributed to its systematic collection and analysis of enormousamountsofdata,adherencetosoundclinicaltrialmethodology, as well as important unanticipated findings.
openaire   +2 more sources

Efficacy of vision restoration therapy after optic neuritis (VISION study): study protocol for a randomized controlled trial

Trials, 2012
Background Optic neuritis is a frequent manifestation of multiple sclerosis. Visual deficits range from a minor impairment of visual functions through to complete loss of vision.
Schinzel Johann, Schwarzlose Lina, Dietze Holger, Bartusch Karolina, Weiss Susanne, Ohlraun Stephanie, Paul Friedemann, Dörr Jan   +7 more
doaj   +1 more source

Experimental mouse model of optic neuritis with inflammatory demyelination produced by passive transfer of neuromyelitis optica-immunoglobulin G. [PDF]

, 2014
Background Although optic neuritis (ON) is a defining feature of neuromyelitis optica (NMO), appropriate animal models of NMO ON are lacking. Most NMO patients are seropositive for immunoglobulin G autoantibodies (NMO-IgG) against the astrocyte water ...
Asavapanumas, N, Bennett, JL, Levin, MH, Papadopoulos, MC, Ratelade, J, Verkman, Alan, Verkman, AS   +6 more
core   +2 more sources

Vestibular Patient Journey: Insights From Vestibular Disorders Association (VeDA) Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Vestibular symptoms impose a high burden of disability. Understanding real‐world diagnostic and treatment pathways can identify care gaps and guide interventions. We aimed to characterize symptom profiles, diagnostic trends, provider involvement, and treatment patterns in vestibular disorders.
Ali Rafati, Sami I. Nassar, Shaun A. Nguyen, Patricia L. Gerend, Michael C. Schubert, Michael T. Teixido, Frederick A. Godley, Joel A. Goebel, Cynthia A. Ryan, Habib G. Rizk, Amir Kheradmand   +10 more
wiley   +1 more source

Treatment Outcomes with the Optic Neuritis Treatment Trial Protocol in Typical Optic Neuritis and Prognostic Factors Associated with Final Visual Acuity: Real-Life Data

Namık Kemal Tıp Dergisi
Aim: This study aims to evaluate the etiological, demographic, and clinical characteristics of patients diagnosed with typical optic neuritis and treated according to the optic neuritis treatment trial (ONTT) protocol, as well as to assess prognostic ...
Abdulkadir Can ÇINAR, Ayça KÜPELİ ÇINAR, Ayşe Naz MUTLU DİNÇ, Tuğçe BEK, Ahmet Kürşad SAKALLIOĞLU, Rüveyde GARİP, Ezgi KULA, Hande GÜÇLÜ   +7 more
doaj   +1 more source

Pediatric multiple sclerosis: update on diagnostic criteria, imaging, histopathology and treatment choices [PDF]

, 2016
Pediatric multiple sclerosis (MS) represents less than 5% of the MS population, but patients with pediatric-onset disease reach permanent disability at a younger age than adult onset patients.
A Ghezzi, A Ghezzi, A Ghezzi, A Ghezzi, A Langer-Gould, A Langer-Gould, A Rovira, A Scalfari, A Scalfari, A Waldman, AH Beecham, AJ Thompson, AK Probstel, B Banwell, B Banwell, B Banwell, B Huppke, B Kornek, BF Popescu, BT Gudbjornsson, C Lechner, C Lucchinetti, C Renoux, C Tornatore, CF Lucchinetti, CF Lucchinetti, CG Lee, CH Polman, CH Polman, CM Dalton, CM Lill, Cris S. Constantinescu, D Chabas, D Miller, DA Hafler, DH Miller, DH Miller, DM Wingerchuk, E Piscolla, EA Yeh, EA Yeh, EM Hennes, F Yang, FD Lublin, G Alper, G Bloomgren, G Filippini, H Butzkueven, Huei-Shyong Wang, I Kister, I Metz, I-Jun Chou, IA Ketelslegers, IA Ketelslegers, J Kira, J Kitley, J Kitley, J O’Mahony, J Palace, J Shimizu, JA Cohen, JK Swanton, JP Fryer, JW Peterson, K Chalmoukou, K Rostasy, KE Harding, L Belbasis, L Bo, L Kappos, L Mantia La, LB Krupp, LH Verhey, M Absinta, M Absoud, M Absoud, M Jurynczyk, M Reindl, MA Friese, MC Mayer, MF Liao, MH Barnett, MH Sun, MW Koch, N Collongues, N Heussinger, O Aktas, O Stuve, P Duquette, P Huppke, P Waters, PJ Waters, PW Schaefer, R Ali, RC Dale, RF Neuteboom, RM Ransohoff, S Bigi, S Jarius, S Lulu, S Pfeifenbring, S Ramanathan, SV Ramagopalan, T Chitnis, T Kanda, T Olsson, T Plavina, TE Lotze, William P. Whitehouse, Y Mikaeloff, Y Mikaeloff, Y Sadaka, YD Fragoso   +112 more
core   +2 more sources

Paramagnetic Rim Lesions Are Associated With Trans‐Synaptic Degeneration of the Visual Pathway in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem, Angel Liu, Sargis Manukyan, Mustafa Subhi, Elaina Luskin, Bryan Quah, Sreekanth Madhusoodhanan Nair, Arzu C. Has Silemek, Gabriela Zabala, Yujie Cui, Laura Locke, Paula Barreras, Marwa Kaisey, Vinicius Calsavara, Daniel S. Reich, Nancy L. Sicotte, Pascal Sati, Omar Al‐Louzi   +17 more
wiley   +1 more source