Results 11 to 20 of about 7,956,506 (236)

Neuroprotection in a novel mouse model of multiple sclerosis. [PDF]

PLoS ONE, 2013
Multiple sclerosis is an immune-mediated, demyelinating and neurodegenerative disease that currently lacks any neuroprotective treatments. Innovative neuroprotective trial designs are required to hasten the translational process of drug development.
Katie Lidster, Samuel J Jackson, Zubair Ahmed, Peter Munro, Pete Coffey, Gavin Giovannoni, Mark D Baker, David Baker   +7 more
doaj   +2 more sources

Optic Neuritis

Journal of Ophthalmic & Vision Research, 2010
Demyelinating optic neuritis is the most common cause of unilateral painful visual loss in the United States. Although patients presenting with demyelinating optic neuritis have favorable long-term visual prognosis, optic neuritis is the initial clinical
Mary Caitlin Dooley
doaj   +1 more source

Treatment Outcomes with the Optic Neuritis Treatment Trial Protocol in Typical Optic Neuritis and Prognostic Factors Associated with Final Visual Acuity: Real-Life Data

Namık Kemal Tıp Dergisi
Aim: This study aims to evaluate the etiological, demographic, and clinical characteristics of patients diagnosed with typical optic neuritis and treated according to the optic neuritis treatment trial (ONTT) protocol, as well as to assess prognostic ...
Abdulkadir Can ÇINAR, Ayça KÜPELİ ÇINAR, Ayşe Naz MUTLU DİNÇ, Tuğçe BEK, Ahmet Kürşad SAKALLIOĞLU, Rüveyde GARİP, Ezgi KULA, Hande GÜÇLÜ   +7 more
doaj   +2 more sources

Development of a novel model of optic neuritis to assess neuroprotective and repair strategies in multiple sclerosis [PDF]

, 2012
PhDMultiple sclerosis (MS) is a putative autoimmune disease of the central nervous system (CNS), which often affects the optic nerve pathway. Optic neuritis (ON) is a clinical feature of MS that can cause loss of vision due to conduction block and ...
Lidster, Katie
core   +4 more sources

Treatment of optic neuritis with erythropoietin (TONE): a randomised, double-blind, placebo-controlled trial-study protocol. [PDF]

, 2016
INTRODUCTION Optic neuritis leads to degeneration of retinal ganglion cells whose axons form the optic nerve. The standard treatment is a methylprednisolone pulse therapy.
Rauer, Sebastian, Beisse, Flemming, Joachimsen, Lutz, Drueschler, Katharina, Molnar, Fanni, Wildemann, Brigitte, Heinrich, Sven P., Sühs, Kurt-Wolfram, Hartmann, Kathrin, Kümpfel, Tania, Hein, Katharina, Wick, Wolfgang, Schiefer, Ulrich, Lagrèze, Wolf A, Drüschler, Katharina, Müller, Matthias, Oterendorp, Christian van, Volkmann, Martin, van Oterendorp, Christian, Wolf, Sebastian, Grotejohann, Birgit, Diem, Ricarda, Mueller, Matthias, Aktas, Orhan, Maurer, Julia, Heesen, Christoph, Heinrich, Sven P, Ihorst, Gabriele, Platten, Michael, Suehs, Kurt-Wolfram, Kernstock, Christoph, Guthoff, Tanja, Gross, Nikolai, Linker, Ralf Andreas, Kuempfel, Tania, Lagreze, Wolf A., Hassenstein, Andrea, Huchzermeyer, Cord, Pielen, Amelie, Albrecht, Philipp, Tonagel, Felix   +40 more
core   +5 more sources

Inebilizumab in AQP4-Seropositive NMOSD: One-Year Follow-Up From a Multicenter, Real-World Study. [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective Real‐world evidence on inebilizumab among neuromyelitis optica spectrum disorder (NMOSD) patients is lacking. This study assessed inebilizumab among Chinese patients with aquaporin 4 autoantibody (AQP4‐IgG)‐seropositive NMOSD in a real‐world setting.
Gui M, Zhan J, Li W, Jin T, He D, Tian D, Li Z, Lin J, Li Y, Zhou H, Bu B.   +10 more
europepmc   +2 more sources

Central serous chorioretinopathy following intravenous steroid therapy for retrobulbar optic neuritis – “Treatment dilemma” – Case report and review of literature

TNOA Journal of Ophthalmic Science and Research, 2021
The adverse reactions of high-dose exogenous steroid administration are well documented, and central serous chorioretinopathy (CSCR) is one among them.
Roshni Mohan, M Arthi, Ayshwaria Basker, Priya Sivakumar   +3 more
doaj   +1 more source

Visual Outcome and Prognostic Factors of Optic Neuritis: A Perspective from the East

Delhi Journal of Ophthalmology, 2016
Optic neuritis is an inflammatory disorder of the optic nerve often resulting in a demyelination process. In the west and in Caucasian populations, the optic neuritis treatment trial demonstrated good recovery and excellent visual outcomes with a ...
Digvijay Singh, Rohit Saxena
doaj   +1 more source

Trial for a trial: Is there hope? – Optic neuritis treatment trial protocol in patients with traumatic optic neuropathy

Kerala Journal of Ophthalmology, 2020
Aims: The aim of this study was to analyze the clinical profile, visual outcome, factors predicting the visual outcome, and response to systemic methylprednisolone as per the Optic Neuritis Treatment Trial (ONTT) protocol in patients with traumatic optic
Jainy Joseph Emmatty, Smita Narayan, Rajini K Cherayath   +2 more
doaj   +1 more source

Optic Neuritis: Clinical Analysis of 27 Cases

Kaohsiung Journal of Medical Sciences, 2003
We retrospectively reviewed 27 cases diagnosed as idiopathic optic neuritis between 1992 and 2001 at Kaohsiung Veterans General Hospital to assess the clinical features, visual prognosis, neuroimaging, laboratory studies, and development of multiple ...
Youn-Shen Bee, Muh-Chiou Lin, Cheng-Chiang Wang, Shwu-Jiuan Sheu   +3 more
doaj   +1 more source