Results 41 to 50 of about 10,950 (228)

Optic neuritis as the initial clinical presentation of limbic encephalitis: a case report

Journal of Medical Case Reports, 2018
Background Limbic encephalitis is characterized by rapid onset of working memory deficit, mood changes, and often seizures. The condition has a strong paraneoplastic association, but not all cases are invariably due to tumors.
Stephanie S. L. Cheung, Gary K. K. Lau, Koon-Ho Chan, Ian Y. H. Wong, Jimmy S. M. Lai, Wai Kiu Tang, Kendrick C. Shih   +6 more
doaj   +1 more source

Lesional-targeting of neuroprotection to the inflammatory penumbra in experimental multiple sclerosis [PDF]

, 2013
The authors would like to thank the support of the National Multiple Sclerosis Society (USA) and the Multiple Sclerosis Society of Great Britain and Northern ...
Al-Izki, S, Amor, S, Baker, D, Browne, L, Chan, AWE, Clutterbuck, L, Garthwaite, J, Gerritsen, WH, Giovannoni, G, Hankey, DJR, Joel, SP, Lidster, K, Montoya, A, Peferoen-Baert, R, Perkins, V, Posada, C, Pryce, G, Selwood, DL, Ummenthum, K, van der Valk, P, von Kutzleben, SM   +20 more
core   +2 more sources

Low Incidence of Relapses After Vaccination in Anti‐Aquaporin‐4 Antibody‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Patients with neuromyelitis optica spectrum disorder (NMOSD) may experience increased signs and symptoms of their underlying disease when vaccinated against meningococcal disease before receiving complement component 5 inhibitor therapies. This retrospective analysis indicated an overall low relapse incidence (mean [range], 3.3% [0.7%–10.6 ...
Sean J. Pittock, Jin Nakahara, Becky Parks, Kerstin Allen, Sami Fam   +4 more
wiley   +1 more source

Correlation of Retinal Nerve Fibre Layer Thickness in Optical Coherence Tomography with Visual Outcome in Optic Neuritis

TNOA Journal of Ophthalmic Science and Research
Purpose: In this study, the changes in optical coherence tomography (OCT) were correlated with the post-treatment visual outcome of optic neuritis, thereby determining the patients who are at risk of optic atrophy. Design: Prospective observational study.
C Usha, M Balasubramanian, M Nivethitha
doaj   +1 more source

MOG encephalomyelitis: international recommendations on diagnosis and antibody testing [PDF]

, 2018
Over the past few years, new-generation cell-based assays have demonstrated a robust association of autoantibodies to full-length human myelin oligodendrocyte glycoprotein (MOG-IgG) with (mostly recurrent) optic neuritis, myelitis and brainstem ...
Aktas, O., Asgari, N., Dale, R. C., Franciotta, D., Fujihara, K., Jacob, A., Jarius, S., Kim, H. J., Kleiter, I., Kümpfel, T., Levy, M., Palace, J., Paul, F., Ruprecht, K., Saiz, A., Seze, J., Trebst, C., Weinshenker, B. G, Wildemann, B.   +18 more
core   +9 more sources

Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Cognitive impairment is common in multiple sclerosis (MS), but manifestations following the first demyelinating event are relatively unexplored. We investigated cross‐sectional associations between magnetic resonance imaging (MRI)–derived brain volumes and the presence of cognitive impairment outcomes five years after the first ...
Piriyankan Ananthavarathan, Marco Pitteri, Michael Foster, Sara Collorone, Sara Salama, Elisa Colato, Ferran Prados, Baris Kanber, Marios Yiannakas, Claudia A. M. Gandini Wheeler‐Kingshott, Indran Davagnanam, Frederik Barkhof, Declan Chard, Olga Ciccarelli, Ahmed Toosy   +14 more
wiley   +1 more source

The clinical profile of new-onset optic neuritis in arabs, a tertiary center experience in Kuwait

Heliyon
Background: Optic neuritis is an inflammatory disorder of the optic nerve and is often the initial manifestation of systemic demyelinating diseases such as multiple sclerosis (MS), neuromyelitis optic spectrum disorder (NMOSD), and myelin-oligodendrocyte
Raed Behbehani, Abdullah Ali, Ahmed Alakool, Samar Farouk, Raed Alroughani   +4 more
doaj   +1 more source

The diagnostic and prognostic value of neurofilament heavy chain levels in immune-mediated optic neuropathies [PDF]

, 2012
Background. Loss of visual function differs between immune-mediated optic neuropathies and is related to axonal loss in the optic nerve. This study investigated the diagnostic and prognostic value of a biomarker for neurodegeneration, the neurofilament ...
Petzold, A, Plant, GT
core   +4 more sources

Understanding Further the Phenotypic Spectrum of Central Nervous System Inflammatory Demyelinating Disorders Using Unsupervised Clustering

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Central nervous system (CNS) inflammatory demyelinating syndromes, including multiple sclerosis (MS), aquaporin‐4 antibody–positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD), occasionally overlap.
Bade Gulec, Elif Everest, Melih Tutuncu, Ugur Bilge, Sabahattin Saip, Ugur Uygunoglu, Aksel Siva   +6 more
wiley   +1 more source

Intravenous methylprednisolone versus oral prednisone for initial attacks of optic neuritis, A review of evidence

Philippine Journal of Ophthalmology, 2005
Objective: To review current available evidence that addresses the question regarding the efficacy of intravenous methylprednisolone and oral-prednisone treatment regimens in improving vision among optic-neuritis patients. Methods: A literature search
Teresita R. Castillo, MD, MHPEd
doaj