Results 61 to 70 of about 10,950 (228)

The multiple sclerosis visual pathway cohort: understanding neurodegeneration in MS [PDF]

, 2017
BACKGROUND: Multiple Sclerosis (MS) is an immune-mediated disease of the Central Nervous System with two major underlying etiopathogenic processes: inflammation and neurodegeneration. The latter determines the prognosis of this disease.
Andorra, Magi, Figueras Roca, Marc, Fraga Pumar, Elena, Gabilondo, Iñigo, Hernández Martinez Lapiscina, Elena, Lampert, Erika, Llufriu Duran, Sara, Martínez-Heras, Eloy, Ortiz Pérez, Santiago, Saiz Hinajeros, Albert, Sánchez Dalmau, Bernardo, Tercero Uribe, Ana, Torres Torres, Ruben, Villoslada, Pablo, Zubizarreta, Irati   +14 more
core   +1 more source

Cancer therapy‐induced ototoxicity: Current challenges and emerging management strategies

Animal Models and Experimental Medicine, EarlyView.
This review comprehensively examines the key risk factors for cancer therapy‐induced ototoxicity, including cumulative drug dose, genetic susceptibility, and combined treatment regimens. It highlights current challenges in ototoxicity monitoring, such as insufficient timeliness and limited clinical adoption, and advocates for standardized auditory ...
Yuqi Huang, Baoying Xu, Xinru Chen, Yu Chen, Dehong Yu   +4 more
wiley   +1 more source

Clinical Profile and a Comparison of Intravenous Methylprednisolone and Oral Prednisolone for Acute Attack of Optic Neuritis Attending at a Tertiary Care Hospital – A Hospital-Based Prospective Study

TNOA Journal of Ophthalmic Science and Research
Purpose: To evaluate the clinical profile and short-term visual outcome of optic neuritis (ON) patients attending to our outpatient department (OPD). Materials and Methods: This prospective observational study carried out over a period of two years among
Sujit Das
doaj   +1 more source

Longitudinal visual field archetypal analysis of optic neuritis treated in a clinical setting

BMJ Open Ophthalmology, 2022
Background/aims We previously used archetypal analysis (AA) to create a model that quantified patterns (archetypes (ATs)) of visual field (VF) loss that can predict recovery and reveal residual VF deficits from eyes in the Optic Neuritis Treatment Trial (
Mark J Kupersmith, Louis R Pasquale, Randy Kardon, Tobias Elze, Joseph Branco, Jui-Kai Wang, Mona K Garvin   +6 more
doaj   +1 more source

Tranexamic Acid Use in Hip Arthroscopy Reduces Bleeding Without Increased Risk of Major Complications: A Systematic Review

Arthroscopy, EarlyView.
Purpose To critically evaluate the impact of tranexamic acid (TXA) on hip arthroscopy outcomes, including its effects on bleeding, functional recovery, postoperative pain, complications, intraoperative visualization, and surgical efficiency. Methods A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic ...
Paul B. Walker, Mathangi Sridharan, Adrian Lin, Atousa Nourmahnad, Alexander Fish, Sharon L. Hame, Kristofer J. Jones   +6 more
wiley   +1 more source

Retinal atrophy in relation to visual functioning and vision-related quality of life in patients with multiple sclerosis [PDF]

, 2017
BACKGROUND: Inner retinal layer atrophy in patients with multiple sclerosis (MS) has been validated as a structural imaging biomarker for neurodegeneration. OBJECTIVE: To determine how retinal layer thickness relates to high-contrast visual acuity (HCVA),
Balk, LJ, Coric, D, Killestein, J, Nij Bijvank, JA, Petzold, A, Uitdehaag, BM   +5 more
core   +1 more source

Exposure‐adjusted safety and efficacy of GLP‐I and GLP‐1/GIP receptor agonists compared with non‐GLP‐I for weight management and type 2 diabetes: Based on FDA medical and statistical reports of 34 280 safety and 36 312 efficacy subjects

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to contextualize glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and glucose‐dependent insulinotropic polypeptide (GIP) receptor agonists safety and efficacy regarding weight management (WM); we analysed Food and Drug Administration (FDA) Medical Reviews to analyse 14 medications using patient‐exposure year normalization and ...
Aishwarya Prasad, Anshu Arora, Arun Arora, Jeena Vaid, Arif Khan   +4 more
wiley   +1 more source

Adverse events in bedaquiline‐ and pretomanid‐based regimens for drug‐resistant tuberculosis from trial, implementation and pharmacovigilance studies

British Journal of Clinical Pharmacology, EarlyView.
Abstract The availability of safety data, particularly concerning adverse events (AEs) associated with the new shorter regimen for drug‐resistant tuberculosis (TB) containing a bedaquiline–pretomanid‐based regimen, is still limited. This systematic review aims to provide a comprehensive and updated analysis of AEs related to this new regimen by ...
Nisa Maria, Annisa Lazuardi Larasati, Indri Yuliani Hamdani, Jin‐Gun Cho, Jan‐Willem C. Alffenaar   +4 more
wiley   +1 more source

Tapering Oral Steroid Treatment After IV Methylprednisolone Pulse Therapy in Demyelinating Optic Neuritis

Caspian Journal of Neurological Sciences, 2018
Background: Optic neuritis is an inflammation of the optic nerve. Because of importance of vision for human, management of optic neuritis is an important issue in neurology.
Seyed-Ehsan Mohammadianinejad, Nastaran Majidinasab, Adel Nejati, Hamidreza Hatamian, Asieh Mehramiri, Seyed-Aidin Sajedi, Saeed Hesam   +6 more
doaj  

Secondary antibody deficiency: a complication of anti-CD20 therapy for neuroinflammation [PDF]

, 2018
B-cell depleting anti-CD20 monoclonal antibody therapies are being increasingly used as long-term maintenance therapy for neuroinflammatory disease compared to many non-neurological diseases where they are used as remission-inducing agents.
Constantinescu, C., Jacob, A., Jolles, Stephen, Paling, D., Robertson, Neil, Tallantyre, Emma, Whittam, D. H.   +6 more
core   +2 more sources