Results 81 to 90 of about 10,950 (228)

Recent Progress In The Diagnosis And Treatment Of Multiple Sclerosis [PDF]

, 1999
Magnetic resonance imaging (MRI) now provides valuable diagnostic and prognostic information for the management of multiple sclerosis (MS) but the diagnosis still largely rests on the clinical features of central nervous system (CNS) lesions disseminated
Achiron, Alam, Barkhof, Barkhof, Barnes, Beck, Bornstein, Calabresi, Calabresi, Callanan, Charcot, Charcot, Cross, Davie, Durelli, Fazekas, Ferguson, Goodkin, Goodkin, Jacobs, Johnson, Katz, Kermode, Losseff, Losseff, Lublin, Lublin, Martin, McDonnell, Michael P Pender, Milligan, Munafo, O'Riordan, Oliveri, Pachner, Paty, Pender, Pender, Pender, Poser, Roelcke, Rudick, Rudick, Rudick, Sellebjerg, Sheean, Sorensen, Stone, Thompson, Thorpe, Trapp, Truyen, Van Walderveen, Yudkin   +53 more
core   +1 more source

What is the incidence and clinical significance of dry eye disease in patients treated with immune checkpoint inhibitors? A systematic review and meta‐analysis of ocular immune‐related adverse events

Acta Ophthalmologica, EarlyView.
Abstract Purpose Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but may cause immune‐related adverse events (irAEs), including dry eye disease (DED). This study aimed to quantify the incidence of ICI‐associated DED and to evaluate factors contributing to variability across studies.
Kai‐Yang Chen, Hoi‐Chun Chan, Chi‐Ming Chan   +2 more
wiley   +1 more source

Neuritis óptica inflamatoria

Anales del Sistema Sanitario de Navarra, 2009
La neuritis óptica inflamatoria (NO) es la causa más frecuente de pérdida visual aguda en adultos jóvenes. Aunque el pronóstico visual es excelente en la mayoría de los casos, muchos pacientes desarrollarán otra patología como esclerosis múltiple en la ...
T. Ayuso Blanco, D. Aliseda Pérez de Madrid, I. Ajuria Foronda, B. Zandío Amorena, S. Mayor Gomez, M.C. Navarro Azpiroz   +5 more
doaj   +1 more source

Optic neuritis - more than a loss of vision [PDF]

, 2009
Optic neuritis (ON) is the presence of an acute inflammation of the optic nerve that results in painful loss of vision. It is the most commonly encountered optic neuropathy in general practice, and is often associated with multiple sclerosis (MS ...
Chen, Celia Shin Wen, Chu, Edward R
core  

Alemtuzumab use in neuromyelitis optica spectrum disorders: a brief case series. [PDF]

, 2016
Alemtuzumab is an anti-CD52 monoclonal antibody recently licensed for use in relapsing-remitting multiple sclerosis. Here, we report our experience of its use in neuromyelitis optica (NMO) spectrum disorders.
Azzopardi, L, Coles, AJ, Cox, AL, Jones, JL, McCarthy, CL   +4 more
core   +1 more source

Aniridia‐associated keratopathy: Clinical and molecular mechanisms of disease progression and emerging therapeutic targets

Acta Ophthalmologica, EarlyView.
Abstract Congenital aniridia is a rare genetic disorder primarily caused by pathogenic variants of the PAX6 gene. It leads to various panocular anomalies, including aniridia‐associated keratopathy (AAK). This review highlights recent insights into its pathogenesis, focusing on clinical staging, microstructural changes in the cornea and molecular ...
N. Szentmáry, S. Suiwal, M. Amini, F. N. Fries, A. Náray, L. Latta, Z. Li, S. Li, S. Liu, S. L. Hsu, S. Kundu, G. Tóth, S. Trusen, J. Zimmermann, B. Seitz, B. Käsmann‐Kellner, Z. Hoxha, A. Langenbucher, O. Stachs, M. Cortón‐Perez, K. Tory, A. Csorba, Z. Z. Nagy, M. C. Acosta, J. Gallar, M. Csidey, E. Maka, T. Stachon   +27 more
wiley   +1 more source

Effect of vitamin A on recovery from the acute phase of multiple sclerosis-related optic neuritis, double-blind, randomized, placebo-controlled trial

Caspian Journal of Internal Medicine, 2023
Background: Optic neuritis (ON) is one of the main neuro-ophthalmic presentations of multiple sclerosis (MS), and it causes optic nerve atrophy and axonal loss. However, so far, there is no effective treatment to improve long-term outcomes. Methods: In a
Shiva Rahimi-Dehgolan, Maryam Masoudi, Shahram Rahimi-Dehgolan, Amir Reza Azimi, Mohammad Ali Sahraian, Seyed Mohammad Baghbanian, Abdorreza Naser Moghadasi   +6 more
doaj  

Increased expression of Tbet in CD4+ T cells from clinically isolated syndrome patients at high risk of conversion to clinically definite MS [PDF]

, 2016
BACKGROUND: The ability to identify clinically isolated syndrome (CIS) patients at high risk of progression to clinically definite multiple sclerosis (CDMS) would be clinically beneficial.
Christopher McGuigan, Jean M. Fletcher, Karen O’Connell, Niall Tubridy, Sharee A. Basdeo, Siobhan Kelly   +5 more
core   +1 more source

Oral versus intravenous high-dose methylprednisolone for treatment of relapses in patients with multiple sclerosis (COPOUSEP) [PDF]

, 2015
International audienceSummaryBackground High doses of intravenous methylprednisolone are recommended to treat relapses in patients with multiple sclerosis, but can be inconvenient and expensive. We aimed to assess whether oral administration of high-dose
Coustans, Marc, Deburghgraeve, Véronique, Edan, Gilles, Hamonic, Stéphanie, Laplaud, David A, Le Page, Emmanuelle, Lebrun, Christine, Veillard, David, Wardi, Rasha, Wiertlewski, Sandrine, Zagnoli, Fabien   +10 more
core   +3 more sources

NEMO‐NDAS: Case Report and Review of the Literature

Pediatric Dermatology, EarlyView.
ABSTRACT NEMO‐deleted exon 5 autoinflammatory syndrome (NEMO‐NDAS) is the result of a gain‐of‐function IKBKG pathogenic variant leading to dysregulated NF‐κB signaling and systemic inflammation. We present a case of NEMO‐NDAS in a 2‐year‐old female presenting with recurrent fevers, subcutaneous nodules, lymphadenopathy, and splenomegaly.
Angela Yang, Kristie Mar, Kimberly A. Morishita, Kevin Meesters, Antonio Torrelo, Joseph M. Lam   +5 more
wiley   +1 more source