Results 1 to 10 of about 7,956,506 (236)

From the Optic Neuritis Treatment Trial to Antibody-Mediated Optic Neuritis: Four Decades of Progress and Unanswered Questions [PDF]

Biomedicines
Optic neuritis (ON) has been recognized since antiquity, but its modern clinical identity emerged only in the late 19th century and was definitively shaped by the Optic Neuritis Treatment Trial (ONTT).
Marco A. Lana-Peixoto, Natália C. Talim, Paulo P. Christo   +2 more
doaj   +7 more sources

The effect of optic neuritis treatment trial (ONTT) combined corticosteroid regimen on pattern reversal visual evoked potentials: a prospective follow-up study [PDF]

BMC Ophthalmology, 2021
Background The combined corticosteroid regimen of the original Optic Neuritis Treatment Trial (ONTT) is used in many centers to treat optic neuritis. Though pattern reversal visual evoked potentials (PRVEPs) are a sensitive, standard measure of visual ...
Padmini Dahanayake, Tharaka L. Dassanayake, Manoji Pathirage, Saman Senanayake, Mike Sedgwick, Vajira S. Weerasinghe   +5 more
doaj   +2 more sources

Development of a predictive model for predicting disability after optic neuritis: a secondary analysis of the Optic Neuritis Treatment Trial

Frontiers in Neurology
ObjectiveThe present study aimed to develop a prediction model for predicting developing debilities after optic neuritis.MethodsThe data for this research was obtained from the Optic Neuritis Treatment Trial (ONTT).
Siqian Wei, Yi Du, Meifeng Luo, Ruitong Song   +3 more
doaj   +5 more sources

Parent and medical professional willingness to enroll children in a hypothetical pediatric optic neuritis treatment trial

Frontiers in Neurology, 2011
The Optic Neuritis Treatment Trial and subsequent studies have had a tremendous impact on the treatment and prognosis of optic neuritis and multiple sclerosis in adults. The results of these studies have been extrapolated to children; however, pediatric
Amy eWaldman, Michael eShumski, Grant T. Liu   +2 more
doaj   +3 more sources

A Challenging Case of MOG-Associated Optic Neuritis: The Role of IL-6 Inhibition in Refractory Disease [PDF]

International Medical Case Reports Journal
Hind Alnajashi,1,2 Mesedah Alnahdi2 1Neurology Department, King Abdulaziz University, Jeddah, Saudi Arabia; 2Neurology Department, King Abdulaziz University Hospital, Jeddah, Saudi ArabiaCorrespondence: Hind Alnajashi, Neurology Department, King ...
Alnajashi H, Alnahdi M
doaj   +2 more sources

Successful Management of Isolated Optic Neuritis in Acute Diseminated Encephalomyelitis: A Case Report [PDF]

Annals of Mechnikov's Institute, 2021
Background: Optic neuritis is an inflammatory disease that results in demyelination of the optic nerve. Isolated Optic Neuritis in Acute Disseminated Encephalomyelitis is a rare case, this disease attacks the central nervous system. It is monophasic, and
Arantrinita Arantrinita, Agustini Lukisiari   +1 more
doaj   +2 more sources

Diffusion Basis Spectrum Imaging Detects Axonal Loss After Transient Dexamethasone Treatment in Optic Neuritis Mice

Frontiers in Neuroscience, 2021
Optic neuritis is a frequent first symptom of multiple sclerosis (MS) for which corticosteroids are a widely employed treatment option. The Optic Neuritis Treatment Trial (ONTT) reported that corticosteroid treatment does not improve long-term visual ...
Tsen-Hsuan Lin, Jie Zhan, Jie Zhan, Chunyu Song, Michael Wallendorf, Peng Sun, Xuan Niu, Ruimeng Yang, Ruimeng Yang, Anne H. Cross, Anne H. Cross, Sheng-Kwei Song, Sheng-Kwei Song, Sheng-Kwei Song   +13 more
doaj   +1 more source

Treatment of Acute Optic Neuritis [PDF]

Archives of Ophthalmology, 2008
inconclusive because of small sample size. In the 1980s, the Optic Neuritis Treatment Trial was developed to evaluate corticosteroid treatment for optic neuritis. This multicenter randomized clinical trial, supported by the National Eye Institute, was designed to answer the following questions: (1) Does treatment with either oral prednisone or ...
Roy W, Beck, Robin L, Gal
openaire   +2 more sources

The Optic Neuritis Treatment Trial

Journal of Neuro-Ophthalmology, 1995
The publications of the Optic Neuritis Treatment Trial (1-3) have generated some misconceptions about the study design and the results. In this article, we offer a digest of how the ONTT was conducted, what it showed, how its results may affect management of optic neuritis, and answers to some of the most frequently asked questions about the validity ...
Roy W. Beck, Jonathan D. Trobe
openaire   +3 more sources

A practical approach to the diagnosis and management of optic neuritis

Annals of Indian Academy of Neurology, 2022
Optic neuritis (ON), as an umbrella term, refers to a spectrum of inflammatory optic neuropathies arising from a myriad of potential causes. In its most common form, “typical” ON presents as a unilateral, painful subacute vision loss event in young ...
Etienne Benard-Seguin, Fiona Costello
doaj   +1 more source