Results 101 to 110 of about 77,061 (306)

Model‐informed precision dosing of carboplatin in cancer patients by leveraging myelosuppression data from electronic health records

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims This study aimed to develop and validate a population pharmacokinetic‐pharmacodynamic (pop‐PK‐PD) model to describe carboplatin‐induced myelosuppression in cancer patients and support dose individualization. Methods Data from 580 cancer patients treated with carboplatin at Amsterdam UMC between 2019 and 2022 were used for model ...
Alessandro De Carlo, Elena Maria Tosca, Mirjam Crul, Tim Schutte, Lia van Zuijlen, Idris Bahce, Medhat M. Said, Jan Buter, Harmen Huls, Paolo Magni, Imke Bartelink   +10 more
wiley   +1 more source

Risk factors for optic neuropathy after clipping for paraclinoid aneurysms: A retrospective study

World Neurosurgery: X
Background: Anterior clinoidectomy (AC) is an important technique for the management of aneurysms in the paraclinoid region. Conventional drill-based AC technique (Drill AC) can cause optic neuropathy. Therefore, starting in July 2017, we transitioned to
Junya Iwama, Hiroki Sato, Seiji Kuribara, Makoto Mizushima, Takumi Hirabayashi, Ryosuke Tsuchiya, Takafumi Shindo, Keisuke Ohnaka, Takanori Hayakawa, Katsumi Takizawa   +9 more
doaj   +1 more source

Magnetic resonance imaging indicator of the causes of optic neuropathy in IgG4-related ophthalmic disease

BMC Medical Imaging, 2019
Background The following study investigates the involvement of optic neuropathy in IgG4-related ophthalmic diseases (IgG4-ROD) based on the magnetic resonance imaging (MRI) data, and different imaging features of IgG4-ROD related optic neuropathy related
Jing Li, Yan Zhang, Hang Zhou, Lei Wang, Zhenchang Wang, Hongyang Li   +5 more
doaj   +1 more source

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

Why do we need optic nerve decompression of traumatic optic neuropathy patients?

Interdisciplinary Neurosurgery, 2014
Traumatic optic neuropathy can be treated by various methods including high-dose steroids and surgical decompression. Neurosurgical decompression could be required in patients with mechanical compression of the optic nerve by displaced orbital roof ...
Seong Rok Han, M.D., Ph.D.
doaj   +1 more source

Traumatic Optic Neuropathy [PDF]

Korean Journal of Neurotrauma, 2018
Traumatic optic neuropathy (TON) refers to optic nerve injury resulting from direct and indirect head and facial trauma. The pathogenesis of indirect TON has not been fully elucidated, and the management of TON remains controversial. In this review article, I review the recent literature regarding TON and discuss how to manage indirect TON.
openaire   +2 more sources

Optical Coherence Tomography Angiography Vessel Density in Healthy, Glaucoma Suspect, and Glaucoma Eyes. [PDF]

, 2016
PurposeThe purpose of this study was to compare retinal nerve fiber layer (RNFL) thickness and optical coherence tomography angiography (OCT-A) retinal vasculature measurements in healthy, glaucoma suspect, and glaucoma patients.MethodsTwo hundred sixty ...
Belghith, Akram, Diniz-Filho, Alberto, Fatehee, Naeem, Huang, David, Manalastas, Patricia Isabel, Medeiros, Felipe A, Saunders, Luke J, Suh, Min Hee, Weinreb, Robert N, Yarmohammadi, Adeleh, Yousefi, Siamak, Zangwill, Linda M   +11 more
core  

Clinical Safety of Extended Interval Dosing of Nivolumab in Patients with Melanoma

Clinical Pharmacology &Therapeutics, EarlyView.
Extended interval dosing regimens of immune checkpoint inhibitors have been implemented widely. However, their approval was mainly based on pharmacokinetic modeling and simulations. Consequently, comparative safety data of extended interval dosing regimens in a real‐world setting are limited.
Ruben Malmberg, Maaike M. Hofman, Fatima Ashad, Alaa Daloul, Stefani Oosterveld, Edwin A. Basak, Esther Oomen‐de Hoop, Astrid A. M. van der Veldt, Arjen Joosse, Roelof W. F. van Leeuwen, Ron H. J. Mathijssen   +10 more
wiley   +1 more source

Nonarteritic anterior ischemic optic neuropathy: cause, effect, and management

Eye and Brain, 2017
Shauna Berry,1 Weijie V Lin,2 Ama Sadaka,1 Andrew G Lee1–7 1Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, TX, USA; 2Department of Ophthalmology, Baylor College of Medicine, Houston, TX, USA; 3Department of
Berry S, Lin WV, Sadaka A, Lee AG
doaj  

Immunophenotypic characteristics of plasma cells in POEMS syndrome

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract To analyze the immunophenotypic characteristics of plasma cells in patients with polyneuropathy, organomegaly, endocrinopathy, myeloma protein, and skin changes (POEMS) syndrome. This retrospective study included patients with POEMS syndrome hospitalized in the Department of Hematology, Huashan Hospital, from September 2017 to August 2025 ...
Zhenhua Wang, Tianling Ding, Beiqian Wu, Qiang Niu, Leyao Gu, Yan Yuan, Ping Zhu   +6 more
wiley   +1 more source