Results 171 to 180 of about 44,099 (219)

Discovery of PHB1 as a Novel Candidate Gene in Dominant Optic Atrophy

Clinical Genetics, EarlyView.
A heterozygous PHB1 missense variant (p.Ser147Phe) segregates with autosomal dominant optic atrophy in a multi‐generation family. Structural and cellular analyses suggest altered mitochondrial dynamics, identifying PHB1 as a novel candidate gene for hereditary optic neuropathy. ABSTRACT Hereditary optic neuropathies comprise a genetically heterogeneous
Marija Volk, Aleš Maver, Martina Jarc Vidmar, Nuša Trošt, Tanja Višnjar, Ana Fakin, Lea Kovač, Maja Šuštar Habjan, Lucija Malinar, Sanja Petrović Pajić, Urška Dragin Jerman, Rok Romih, Marko Hawlina, Borut Peterlin   +13 more
wiley   +1 more source

Think Outside the Lyme Box: Optic Neuropathy and Polyarthritis Caused by Borrelia miyamotoi. [PDF]

Cureus
Nagahata K, Ikeda T, Tsuji Y.
europepmc   +1 more source

Next‐Generation Strategies for Neural Repair and Regeneration: Neural Organoid Transplantation in the CNS

Cell Proliferation, EarlyView.
Neurological disorders are hard to treat. Stem cell‐derived neural organoids enable research, and their transplantation aids CNS therapy, with this article reviewing relevant advances, challenges and prospects. ABSTRACT Neurological disorders are often devastating and notoriously difficult to repair, creating an urgent need for novel research models ...
Yutong Wang, Jinrui Li, Xingjia Mao, Wanyu Wang, Yansong Li, Xuefei Hu, Jinjie Zhong, Fengdong Zhao, Linlin Wang   +8 more
wiley   +1 more source

Retinal Capillary Density Reduction Contributes to Dysthyroid Optic Neuropathy via an L-Arginine-NO Pathway: A Metabonomics and Clinical Trial Study. [PDF]

MedComm (2020)
Tu Y, Yan C, Chen L, Liu W, Hu X, Gao M, Rao W, Zhang J, Zhu J, Wu H, Zhang K, Zhou M, Wu W.   +12 more
europepmc   +1 more source

Leber hereditary optic neuropathy triggered by the AstraZeneca coronavirus disease 2019 vaccination.

Oman J Ophthalmol
Aljawi AA, Badeeb NO.
europepmc   +1 more source

Leber's Hereditary Optic Neuropathy. [PDF]

Med Arch
Popovic-Beganovic A, Dzinic V.
europepmc   +1 more source

Colorectal cancer outcomes show relationships with the type and extent of vascular complications in individuals with diabetes: A population‐based study

Diabetic Medicine, EarlyView.
Abstract Aims Diabetes is associated with poorer prognosis and treatment‐related outcomes in patients with cancer. Major surgical resection is the mainstay of potentially curative treatment for colorectal cancer (CRC). This study aimed to assess whether the risk of adverse outcomes for individuals with diabetes and CRC varies by diabetes status and ...
Rebecca J. Birch, John C. Taylor, Amy Downing, Philip Quirke, Paul Finan, Katie Spencer, Eva J. A. Morris, Simon Howell, Ramzi A. Ajjan   +8 more
wiley   +1 more source

Bilateral methanol-induced optic neuropathy following hand sanitizer ingestion. [PDF]

Am J Ophthalmol Case Rep
Sherman CS, Oatts JT, Sarlo D.
europepmc   +1 more source

Evaluation of a secondary care multidisciplinary clinic for adults with early‐onset type 2 diabetes at high risk in Leicester, Leicestershire and Rutland

Diabetic Medicine, EarlyView.
Abstract Background Clinical services for adults with early‐onset type 2 diabetes (EOT2D) are in urgent need of improvement. Methods We evaluated a multi‐disciplinary clinic for individuals with EOT2D at high risk (HbA1c >9%/triglyceride >20 mmol/L), providing 2–3 flexibly arranged consultations per individual between March 2024 and September 2025 ...
Jonathan Goldney, Malak Hamza, Priscilla Sarkar, Harriet Morgan, Nicole Green, James Ridgeway, Victoria Alabraba, Laura Willcocks, Krupali Chandracant, Kashmala Javed, Rhys O'Callaghan, Finley Turner, Samuel Seidu, Claire L. Meek, Melanie J. Davies   +14 more
wiley   +1 more source

Multimodal optical coherence tomography and angiography and serologic markers for accurate early diagnosis of dysthyroid optic neuropathy. [PDF]

Am J Transl Res
Zhao Y, Xiao Q, Fan B, Tang L, Chen X, Dai Y.   +5 more
europepmc   +1 more source