Results 41 to 50 of about 153,319 (310)
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Future broadband access network challenges
, 2010 Copyright @ 2010 IEEEThe optical and wireless communication systems convergence will activate the potential capacity of photonic technology for providing the expected growth in interactive video, voice communication and data traffic services that are ...
Nilavalan, R +7 more
core +1 more source
IEEE Photonics Journal, 2023 The All-Photonics Metro-Access Converged Network (APN) aims to achieve a flat and simple architecture that even covers access areas and represents the evolution of optical transport.
Shin Kaneko +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
High-Capacity Free Space Optics-Based Passive Optical Network for 5G Front-Haul Deployment
, 2023 With the expansion of Information and Communication Technology, it is important to develop a communication network that can provide high-capacity ubiquitous connectivity.
Sibghat Ullah +7 more
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
A comparative study of the performance of seven- and 63-chip optical code-division multiple-access encoders and decoders based on superstructured fiber Bragg gratings [PDF]
, 2001 We report a range of elementary optical coding and decoding experiments employing superstructured fiber Bragg grating (SSFBG) components: first, we perform a comparative study of the relative merits of bipolar and unipolar coding: decoding schemes and ...
Teh, Peh Chiong +3 more
core +1 more source
Study and Test on Energy-Saving Technology of Optical Access Network
Dianxin kexue, 2013 According to the energy consumption status and network characteristics of the optical access network，the energy consumption distribution and the main factors that could affect energy consumption in optical access network environment were analyzed.
Yan Jiang, Zhanhai Zhuang
doaj +2 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source