Results 51 to 60 of about 153,319 (310)

Study on the Solutions to Heterogeneous ONU Propagation Delays for Energy-Efficient and Low-Latency EPONs

IEEE Access, 2020
The scattered Optical Network Units (ONUs) in an optical access network have different propagation delays. In an Ethernet passive optical network (EPON) adopting the traditional Interleaved Polling with Adaptive Cycle Time (IPACT) scheme, such ONU ...
Yunxin Lv, Meihua Bi, Yanrong Zhai, Hao Chi, Yuxi Wang   +4 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

A Lightweight Two-Way Authentication Scheme Between Communication Nodes for Software Defined Optical Access Network

IEEE Access, 2019
For the rapid increase in the number of optical line terminals (OLTs) and optical network units (ONUs) connected to the control center in the software defined optical access network (SDOAN) environment, the security problems caused by the communication ...
Yongli Tang, Tao Liu, Xu He, Jinxia Yu, Panke Qin   +4 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Optical multiple access by receiver access control protocol for optical wireless networks [PDF]

2011 IEEE GLOBECOM Workshops (GC Wkshps), 2011
Optical wireless networks often require more than one transmitter to maintain consistent connection with a single receiver. Accordingly, an efficient control mechanism is required to address challenges associated with multiple access to the receiver. This paper proposes a receiver access control (RAC) mechanism for optical wireless mesh networks that ...
Falahpour, Maryam, Moradi, Hassan, Refai, Hazem H., LoPresti, Peter G.   +3 more
openaire   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Techno-Economic Analysis of Active Optical Network Migration Toward Next-Generation Optical Access

, 2017
Active optical networks (AONs) have been one of the most deployed fiber access solutions in Europe. However, with the increasing traffic demand, the capacity of the existing AONs is becoming insufficient. For the legacy AONs, there are two major variants
Chen, Jiajia,, Gavler, Anders,, Urban, Patryk J.,, A. Gavler, K. Brunnström, J. Chen, Gavler, A.,, Wosinska, Lena,, Chen, J.,, L. Wosinska, MasMachuca, C.,, C. Mas Machuca, Wang, K.,, P. J. Urban, Urban, P. J.,, Wosinska, L.,, Brunnström, Kjell,, Wang, Kun,, K. Wang, Mas Machuca, Carmen,   +19 more
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Fault Tolerant Spectral/Spatial Optical Code Division Multiple Access Passive Optical Network

Sensors
High-capacity communication networks are built to provide high throughput and low latency to accommodate the growing demand for bandwidth. However, the provision of these features is subject to a robust underlying network, which can provide high capacity
Rahat Ullah, Sibghat Ullah, Jianxin Ren, Yaya Mao, Zhipeng Qi, Jamil Hussain, Feng Wang, Faheem Khan, Waqas Ahmed Imtiaz   +8 more
doaj   +1 more source