Results 61 to 70 of about 532,754 (349)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Microfabricated high-finesse optical cavity with open access and small volume [PDF]

, 2005
We present a microfabricated optical cavity, which combines a very small mode volume with high finesse. In contrast to other micro-resonators, such as microspheres, the structure we have built gives atoms and molecules direct access to the high-intensity
Beckmann P., E. A. Curtis, E. A. Hinds, E. Kukharenka, M. Kraft, M. Trupke, Motamedi M., S. Eriksson, Z. Moktadir   +8 more
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Wavelength Reuse for Short-Reach Optical Access Network Utilizing MDM

IEEE Photonics Journal, 2017
Wavelength reuse has been proposed as an effective solution to realize colorless optical network units (ONUs) for next-generation passive optical network with simplified maintenance and reduced cost.
Yuanxiang Chen, Juhao Li, Jinglong Zhu, Paikun Zhu, Yu Tian, Huangfa Peng, Yongchi Xu, Jingbiao Chen, Yongqi He, Zhangyuan Chen   +9 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Fault Tolerant Spectral/Spatial Optical Code Division Multiple Access Passive Optical Network

Sensors
High-capacity communication networks are built to provide high throughput and low latency to accommodate the growing demand for bandwidth. However, the provision of these features is subject to a robust underlying network, which can provide high capacity
Rahat Ullah, Sibghat Ullah, Jianxin Ren, Yaya Mao, Zhipeng Qi, Jamil Hussain, Feng Wang, Faheem Khan, Waqas Ahmed Imtiaz   +8 more
doaj   +1 more source

Entanglement Distribution in Optical Networks [PDF]

, 2014
The ability to generate entangled photon-pairs over a broad wavelength range opens the door to the simultaneous distribution of entanglement to multiple users in a network by using centralized sources and flexible wavelength-division multiplexing schemes.
Ciurana, Alex, Martin, Vicente, Martinez-Mateo, Jesus, Peev, Momtchil, Poppe, Andreas, Schrenk, Bernhard   +5 more
core  

Densely Integrated Photonic Devices based on Microring Resonators in Access Networks [PDF]

, 2007
The application of optical fibers has led to virtually lossless point to point data links in the core network with practically unlimited bandwidth. In response to increasing bandwidth demands of consumers the optical techniques employed in these networks
Driessen, Alfred, Klein, Edwin J.
core   +4 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source