Results 71 to 80 of about 493,288 (280)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Optical Computing and Computational Complexity
, 2006 This work concerns the computational complexity of a model of computation that is inspired by optical computers. The model is called the continuous space machine and operates in discrete timesteps over a number of two-dimensional images of fixed size and arbitrary spatial resolution.
openaire +2 more sources
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Experimental Demonstration of a Quantum Circuit using Linear Optics Gates
, 2004 One of the main advantages of an optical approach to quantum computing is the fact that optical fibers can be used to connect the logic and memory devices to form useful circuits, in analogy with the wires of a conventional computer.
B. C. Jacobs +3 more
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Monolithically integrated asynchronous optical recurrent accelerator
eLightComputing with light is widely recognized as a promising paradigm for overcoming the energy and latency limitations of electronic computing. However, the energy consumption and latency in current optical computing hardware predominantly arise in the ...
Bo Wu +9 more
doaj +1 more source
All-optical wavelength-tunable narrow-linewidth fiber laser
, 2017 Parameter regulations of narrow-linewidth fiber lasers in frequency domain has drawn considerable interests for widespread applications in the light quantum computing, precise coherent detection, and generation of micro-waves. All-optical methods provide
Cao, Yulong +5 more
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Ultrafast optical spin echo for electron spins in semiconductors
, 2009 Spin-based quantum computing and magnetic resonance techniques rely on the ability to measure the coherence time, T2, of a spin system. We report on the experimental implementation of all-optical spin echo to determine the T2 time of a semiconductor ...
C. P. Slichter +6 more
core +1 more source