Results 111 to 120 of about 498,908 (256)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Verification of an in Process Optical System based on High Resolution Interferometry for Detecting Flexible PV Barrier Films Defects [PDF]

, 2014
The relationship between surface morphology, defects density and water vapor permeability of aluminium oxide (Al2O3) barrier coating on polyethylene naphthalate (PEN) films, used particularly to prevent water vapor and/or oxygen ingress into flexible ...
Blunt, Liam, Elrawemi, Mohamed, Fleming, Leigh, Gao, Feng, Muhamedsalih, Hussam   +4 more
core  

Detecting the tunneling rates for strongly interacting fermions on optical lattices

, 2010
Strongly interacting fermionic atoms on optical lattices are studied through a Hubbard-like model Hamiltonian, in which tunneling rates of atoms and molecules between neighboring sites are assumed to be different. In the limit of large onsite repulsion U,
Anfossi, Alberto, Barbiero, Luca, Montorsi, Arianna   +2 more
core   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Entangled states of trapped ions allow measuring the magnetic field gradient of a single atomic spin

, 2012
Using trapped ions in an entangled state we propose detecting a magnetic dipole of a single atom at distance of a few $\mu$m. This requires a measurement of the magnetic field gradient at a level of about 10$^{-13}$ Tesla/$\mu$m.
Dorner U., F. Schmidt-Kaler, Grotz B., Hemmerling B., Jackson J. D., Kirchmair G., R. Gerritsma, Schmidt P.   +7 more
core   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

High-Speed Microprocessor-Based Optical Instrumentation for the Detection and Analysis of Hydrodynamic Cavitation Downstream of an Additively Manufactured Nozzle

Fluids
This study presents the development and validation of a high-speed optical data acquisition system for detecting and characterizing hydrodynamic cavitation downstream of a triangular nozzle.
Luís Gustavo Macêdo West, André Jackson Ramos Simões, Leandro do Rozário Teixeira, Lucas Ramalho Oliveira, Juliane Grasiela de Carvalho Gomes, Igor Silva Moreira dos Anjos, Antonio Samuel Bacelar de Freitas Devesa, Leonardo Rafael Teixeira Cotrim Gomes, Lucas Gomes Pereira, Iran Eduardo Lima Neto, Júlio Cesar de Souza Inácio Gonçalves, Luiz Carlos Simões Soares Junior, Germano Pinto Guedes, Geydison Gonzaga Demetino, Marcus Vinícius Santos da Silva, Vitor Leão Filardi, Vitor Pinheiro Ferreira, André Luiz Andrade Simões, Luciano Matos Queiroz, Iuri Muniz Pepe   +19 more
doaj   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source