Results 51 to 60 of about 498,908 (256)

Optical excitation and detection of neuronal activity [PDF]

open access: yes, 2017
Optogenetics has emerged as an exciting tool for manipulating neural activity, which in turn, can modulate behavior in live organisms. However, detecting the response to the optical stimulation requires electrophysiology with physical contact or ...
Gillette, Martha   +8 more
core   +2 more sources

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi   +5 more
wiley   +1 more source

Optical Safety System [PDF]

open access: yesEngineering and Technology Journal, 2016
Laser fence is a mechanism used to detect objects that passes vision line between the laser source and optical detector. While, Motion detection theory is the operation of detecting a variation in the location of a body relative to its environment or a ...
Ayad Z. Mohammed   +2 more
doaj   +1 more source

Automated Geological Landmarks Detection on Mars Using Deep Domain Adaptation From Lunar High-Resolution Satellite Images

open access: yesIEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2022
The diversity in geological characteristics on the planetary surface, such as distribution (density), size, shapes, floor structures, ages, and availability of various input data types such as optical, thermal images, and digital elevation maps pose ...
Rasha Alshehhi, Claus Gebhardt
doaj   +1 more source

Detecting Chiral Edge States in the Hofstadter Optical Lattice

open access: yes, 2012
We propose a realistic scheme to detect topological edge states in an optical lattice subjected to a synthetic magnetic field, based on a generalization of Bragg spectroscopy sensitive to angular momentum.
Beugnon, Jerome   +2 more
core   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Broadband optical radiation detector [PDF]

open access: yes, 1981
A method and apparatus for detecting optical radiation by optically monitoring temperature changes in a microvolume caused by absorption of the optical radiation to be detected is described.
Gupta, A., Hong, S. D., Moacanin, J.
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

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