Results 71 to 80 of about 179,886 (315)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Evanescent field sensing in novel flat fiber

, 2008
Recently developed novel 'flat fiber' substrate promises flexible, long-haul integrated optical devices. Here, we present the first demonstration of one such device; an evanescent field sensor, based upon direct UV written Bragg ...
Gawith, C.B.E., A.S. Webb, P.G.R. Smith, C.B.E. Gawith, Holmes, C., F.R. Mahamd Adikan, Gates, J.C., Webb, A.S., J.K. Sahu, Payne, D.N., Smith, P.G.R., D.N. Payne, J.C. Gates, C. Holmes, Adikan, M.F.R., Sahu, J.K.   +15 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Distributed Partial Discharge Locating and Detecting Scheme Based on Optical Fiber Rayleigh Backscattering Light Interference

, 2023
Optical fiber sensors are used for partial discharge detection in many applications due their advantage of strong anti-electromagnetic interference capability.
Yashuai Han, Dawei Zhang, Xianfeng Zheng, Jun Qu, Xinyan Yang, Hao Liu, Zhengxian Zhou   +6 more
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Integrated Optical Motion Detection

, 1986
Two systems for detecting the motion of a scene are described. For both, an image is projected directly onto an integrated circuit that contains photosensors and computing circuitry to extract the motion. The first system, which has been reported earlier, correlates the analog image with a digitized version of the image stored from the previous cycle ...
openaire   +2 more sources

Experimental Detection of the Optical Pendellösung Effect [PDF]

Physical Review Letters, 2006
We report observations of periodic oscillatory behavior of the angular selectivity, near the Bragg angle, in volume holographic gratings recorded in a new photopolymerizable glass with high refractive index modulation. We have detected the presence of overmodulation in the intensity distribution of the first diffraction order. The results reported here
Calvo, M. L., Cheben, Pavel, Martínez-Matos, O., del Monte, F., Rodrigo, J.   +4 more
openaire   +5 more sources

A metalens for detecting fractional-order optical vortices

Компьютерная оптика
In this work, a metalens for detecting an incident field with a fractional topological charge ranging from – 2 to 0 is proposed. The metalens is based on a spiral zone plate with a topological charge of 1.5.
A.G. Nalimov, V.V. Kotlyar, Y.V. Khanenko, S.D. Poletaev   +3 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Automatic detection of Cyanobacterial blooms using multi-source optical satellite imagery: method development and application

Ecological Indicators
Cyanobacterial blooms (CyanoBloom) are a widespread environmental concern in lakes, and optical satellite imagery has been widely used to monitor their spatiotemporal dynamics.
Hailong Zhang, Chen Lu, Deyong Sun, Xiaomin Ye, Shengqiang Wang, Quan Qin   +5 more
doaj   +1 more source