Results 81 to 90 of about 179,886 (315)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Detecting Anomalies in the Optical Layer Using Unsupervised Machine Learning

We propose an unsupervised machine learning (ML) approach using field data for the detection of optical layer anomalies.
Tremblay, Christine,, Aladin, Sandra,, Wosinska, Lena,   +2 more
core   +1 more source

Detecting the trapping of small metal nanoparticles in the gap of nanoantennas with optical second harmonic generation [PDF]

The second harmonic generation from gold nanoparticles trapped into realistic and idealized gold nanoantennas is numerically investigated using a surface integral equations technique.
Martin, O. J. F., Lovera, Andrea, Butet, Jérémy   +2 more
core   +1 more source

Moving Object Detection Using a Stereo Camera Mounted on a Moving Platform

SICE Journal of Control, Measurement, and System Integration, 2017
In this paper, we propose a method for detecting moving objects using a moving stereo camera. First, the camera motion parameters are estimated by using optical flow with a stereo camera.
Tetsuro Toda, Gakuto Masuyama, Kazunori Umeda   +2 more
doaj   +1 more source

Creation of an optical sensor based on the pCdTe – nCdS and pCdTe – nCdSe heterostructure for detecting polluted air [PDF]

E3S Web of Conferences
This article discusses the creation of optical sensors for detecting polluted air based on the pCdTe – nCdS and pCdTe – nCdSe heterostructures. It was established that the developed optical sensors, with an automatic control system using Arduino, operate
Otajonov Salim, Ergashev Ravshanbek, Xaydarov Zokir, Botirov Kadir, Bahromov Mansur, Axmedov Tursun, Raxmonkulov Muxammdjon   +6 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Remote detection optical magnetometry

Physics Reports
Sensitive magnetometers have been applied in a wide range of research fields, including geophysical exploration, bio-magnetic field detection, ultralow-field nuclear magnetic resonance, etc. Commonly, magnetometers are directly placed at the position where the magnetic field is to be measured.
Alexander M. Akulshin, Dmitry Budker, Felipe Pedreros Bustos, Tong Dang, Emmanuel Klinger, Simon M. Rochester, Arne Wickenbrock, Rui Zhang   +7 more
openaire   +3 more sources

Ultrasensitive Optical Sensing Based on Non-Hermitian Metasurfaces

, 2019
We present here an ultrasensitive optical sensing technique based on the parity-time (PT)-symmetric non-Hermitian metasurfaces. The system is composed of a pair of active and passive metasurfaces with the subtle gain-loss balance. Specifically, these two
Chen, Pai-Yen, Farhat, Mohamed
core   +1 more source