Results 51 to 60 of about 1,993 (216)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Feedback Regimes of LFI Sensors: Experimental Investigations

Sensors, 2022
In this article, we revisit the concept of optical feedback regimes in diode lasers and explore each regime experimentally from a somewhat unconventional point of view by relating the feedback regimes to the laser bias current and its optical feedback ...
Karl Bertling, Xiaoqiong Qi, Thomas Taimre, Yah Leng Lim, Aleksandar D. Rakić   +4 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Characterizing Extreme Events in a Fabry–Perot Laser with Optical Feedback

Photonics
The study of extreme events (EEs) in photonics has expanded significantly due to straightforward implementation conditions. EEs have not been discussed systematically, to the best of our knowledge, in the chaotic dynamics of a Fabry–Perot laser with ...
Shanshan Ge, Yu Huang, Kun Li, Pei Zhou, Penghua Mu, Xin Zhu, Nianqiang Li   +6 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Competition between Entrainment Phenomenon and Chaos in a Quantum-Cascade Laser under Strong Optical Reinjection

Photonics, 2022
The topic of external optical feedback in quantum-cascade lasers is relevant for stability and beam-properties considerations. Albeit less sensitive to external optical feedback than other lasers, quantum-cascade lasers can exhibit several behaviors ...
Olivier Spitz, Lauréline Durupt, Frédéric Grillot   +2 more
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Agile cavity ringdown spectroscopy enabled by moderate optical feedback to a quantum cascade laser

Opto-Electronic Advances
Cavity ringdown spectroscopy (CRDS), relying on measuring the decay time of photons inside a high-finesse optical cavity, offers an important analytical tool for chemistry, physics, environmental science, and biology.
Qinxue Nie, Yibo Peng, Qiheng Chen, Ningwu Liu, Zhen Wang, Cheng Wang, Wei Ren   +6 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Resonant fiber scanner with optical feedback

Optics Express, 2014
The addition of an apertured mirror before the imaging lens is proposed as a method of providing feedback in a single-axis resonant fiber scanner. Reflection at the scan extremities generates timing signals interlaced with back-scattered data, and a phase locked loop and a proportional controller then adjust the drive frequency and amplitude.
Mokhtar, MHH, Syms, RRA
openaire   +4 more sources