Results 61 to 70 of about 449,684 (296)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Intensity noise in ultra-high frequency modulated semiconductor laser with strong feedback and its influence on noise figure of RoF links [PDF]

Journal of the European Optical Society-Rapid Publications, 2013
We characterize the intensity noise associated with the ultra-high frequency direct modulation of semiconductor lasers under strong optical feedback over a millimeter-wave frequency passband between 54.5 and 56.5 GHz.
Ahmed M., Bakry A., Altuwirqi R., Alghamdi M. S., Koyama F.   +4 more
doaj   +1 more source

Parameter Optimization for Modulation-Enhanced External Cavity Resonant Frequency in Fiber Fault Detection

Photonics, 2023
Fiber fault detection is crucial for maintaining the quality of optical communication, especially in well-established optical access networks with extended distances and a growing number of subscribers.
Xiuzhu Li, Min Zhang, Haoran Guo, Zixiong Shi, Yuanyuan Guo, Tong Zhao, Anbang Wang   +6 more
doaj   +1 more source

Phase conjugate fluorozirconate fibre laser operating at 800nm [PDF]

, 1992
We report phase-conjugate feedback into a fluorozirconate optical fiber amplifier at infrared wavelengths. By using a semiconductor laser diode at 807 nm, a grating is established in photorefractive BaTiO3 that, in the ring configuration, provides ...
Carter, Cronin-Golomb, Daryl Szebesta, Graeme W. Ross, Jeremy N. Carter, Kogelnik, McMichael, Nielsen, Raman Kashyap, Ramsey, Robert W. Eason, Stephen W. James, Steven T. Davey   +12 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Feedback Regimes of LFI Sensors: Experimental Investigations

Sensors, 2022
In this article, we revisit the concept of optical feedback regimes in diode lasers and explore each regime experimentally from a somewhat unconventional point of view by relating the feedback regimes to the laser bias current and its optical feedback ...
Karl Bertling, Xiaoqiong Qi, Thomas Taimre, Yah Leng Lim, Aleksandar D. Rakić   +4 more
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Characterizing Extreme Events in a Fabry–Perot Laser with Optical Feedback

Photonics
The study of extreme events (EEs) in photonics has expanded significantly due to straightforward implementation conditions. EEs have not been discussed systematically, to the best of our knowledge, in the chaotic dynamics of a Fabry–Perot laser with ...
Shanshan Ge, Yu Huang, Kun Li, Pei Zhou, Penghua Mu, Xin Zhu, Nianqiang Li   +6 more
doaj   +1 more source

Optical bistability in nonlinear system with two loops of feedback

, 2010
A model of nonlinear optical system surrounded by two loops of feedback is investigated. The cell with the vapor of rubidium - type atoms is taken in the capacity of nonlinear element. Two modes of near-resonant electromagnetic field interacting with the
Miroshnichenko, George P., Trifanov, Alexander I.   +1 more
core   +1 more source