Results 41 to 50 of about 2,541 (217)

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

Population pharmacokinetic/pharmacodynamic modelling to evaluate favipiravir in combination with lopinavir–ritonavir in patients with COVID‐19

British Journal of Clinical Pharmacology, EarlyView.
Aims The repurposed use of favipiravir in COVID‐19 has been reported to have limited clinical efficacy, yet it has been widely used in some countries. Favipiravir causes mutagenesis in RNA viruses, and it is currently unknown whether it may have a measurable effect on the virus in humans.
Akosua A. Agyeman, Laura Buggiotti, Li‐An K. Brown, Jose A. Guerra‐Assuncao, Japhette E. Kembou‐Ringert, Wen Y. Mak, Judith Breuer, David M. Lowe, Joseph F. Standing, FLARE Investigators   +9 more
wiley   +1 more source

The decline of 6‐thioguanine nucleotides is not linked to impaired efficacy or safety of thiopurines in pregnant women with inflammatory bowel disease

British Journal of Clinical Pharmacology, EarlyView.
Background Thiopurines are used to maintain remission in inflammatory bowel disease (IBD). These drugs are metabolized into 6‐thioguanine nucleotides (6‐TGN), associated with efficacy, and 6‐methylmercaptopurine ribonucleotides (6‐MMPR), associated with adverse drug reactions. Pregnancy has been linked to a shift in thiopurine metabolism, characterized
Dianne G. Bouwknegt, Paola Mian, Femke Groen, Denise van den Berg‐Zuiddam, Andrea E. van der Meulen, Femke Crouwel, Nanne K. de Boer, Debbie S. Deben, Dennis R. Wong, Luc J. J. Derijks, Gerard Dijkstra, Arno R. Bourgonje, C. Janneke van der Woude, Marijn C. Visschedijk   +13 more
wiley   +1 more source

Shock Cooling and Breakout Emission for Optical Flares Associated with Gravitational-wave Events

The Astrophysical Journal
The astrophysical origin of stellar-mass black hole (BH) mergers discovered through gravitational waves (GWs) is widely debated. Mergers in the disks of active galactic nuclei (AGNs) represent promising environments for at least a fraction of these ...
Hiromichi Tagawa, Shigeo S Kimura, Zoltán Haiman, Rosalba Perna, Imre Bartos   +4 more
doaj   +1 more source

S. aureus colonization and clinical symptoms remain stable upon topical XZ.700 treatment: Results of a double‐blind randomized clinical trial in patients with mild to moderate atopic dermatitis

British Journal of Clinical Pharmacology, EarlyView.
Aim Recovering dysbiosis may improve atopic dermatitis (AD) symptoms. XZ.700 is a recombinant chimeric endolysin that specifically targets Staphylococcus aureus and could be a new treatment option for patients with AD. The aim of this first‐in‐human study was to evaluate the safety, tolerability and efficacy of topical XZ.700 and explore the ...
Laura W. J. van der Meulen, Menthe E. Bergmans, Salma Assil, Naomi Klarenbeek, Marieke L. de Kam, Alexa J. Tibboel, Thorsten Brach, Bjorn L. Herpers, Johan Frieling, Vincent de Jong, Benthe Freyee, Martijn B. A. van Doorn, Robert Rissmann, Tessa Niemeyer–van der Kolk   +13 more
wiley   +1 more source

Magnetic Field Amplification and Blazar Flares

EPJ Web of Conferences, 2013
Recent multiwavelength observations of PKS 0208-512 by SMARTS, Fermi, and Swift revealed that γ-ray and optical light curves of this flat spectrum radio quasars are highly correlated, but with an exception of one large optical flare having no ...
Chen Xuhui, Chatterjee Ritaban, Fossati Giovanni, Pohl Martin   +3 more
doaj   +1 more source

‘Where are the adults?’: Troubling child‐activism and children's political participation

British Educational Research Journal, EarlyView.
Abstract Children's political participation is a well‐established theme in childhood studies. In this article we offer an original account of child activism that takes into account the entangled and emergent aspect of children as activists. We begin with a historical and a conceptual review, noting the importance of mid‐20th century developments such ...
Sharon Hunter, Claire Cassidy
wiley   +1 more source

Flaring Behavior in the M Dwarf PM J11183+1347 from TESS Observations

The Astrophysical Journal
This study presents analysis of the flaring properties and magnetic activity of an M dwarf PM J11183+1347 based on photometry light curves from the Transiting Exoplanet Survey Satellite (TESS) mission. PM J11183+1347 is an active flaring star of dMe type,
Dorothy M. Mwanzia, Rajib Kumbhakar, Soumen Mondal, Sneh Lata, Geoffrey Okeng’o, Samrat Ghosh, John Buers   +6 more
doaj   +1 more source

Beyond the Reports: Cultural Pressures, Unheard Voices and the Climate Accountability Gap in Oil and Gas Sector Governance

Business Strategy and the Environment, EarlyView.
ABSTRACT Environmental governance in Nigeria's oil and gas sector remains central to global climate justice debates, yet persistent accountability failures continue to undermine meaningful environmental and social outcomes. Despite extensive regulatory frameworks, accountability in resource‐dependent contexts is frequently reduced to formal reporting ...
Hammed Afolabi, Ronita Ram, Adetola Abdulfattah Sogbesan   +2 more
wiley   +1 more source

AT 2019aalc: A Bowen Fluorescence Flare with a Precursor Flare in an Active Galactic Nucleus

The Astrophysical Journal
AT 2019aalc is a peculiar sequence of highly variable emission events observed towards the nucleus of the broad-line active galactic nucleus (AGN) SDSS J152416.66+045119.0.
Marzena Śniegowska, Benny Trakhtenbrot, Lydia Makrygianni, Iair Arcavi, Claudio Ricci, Sara Faris, Biswaraj Palit, D. Andrew Howell, Megan Newsome, Joseph Farah, Curtis McCully, Estefania Padilla-Gonzalez, Giacomo Terreran   +12 more
doaj   +1 more source