Results 91 to 100 of about 584,548 (310)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Single-atom imaging of fermions in a quantum-gas microscope
, 2015 The authors acknowledge support by EU (ERC-StG FERMILATT, SIQS, Marie Curie Fellowship to E.H.), EPSRC, Scottish Universities Physics Alliance (SUPA).Single-atom-resolved detection in optical lattices using quantum-gas microscopes has enabled a new ...
Bruno Peaudecerf +13 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Advanced optical imaging methods for investigating manuscripts
, 2011 This paper gives an overview of advanced optical imaging methods relevant to the study of manuscripts. While some of the methods covered are well established, others are very much in active development.
Liang, H
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
High-dynamic-range imaging optical detectors
, 2002 Imaging spectrometers allowing spatially resolved targets to be spectrally discriminated are valuable for remote sensing and defense applications. The drawback of such instruments is the need to quickly process very large amounts of data.
Coutinho, R.C. +2 more
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Illumination waveform optimization for time-of-flight range imaging cameras
, 2011 Time-of-flight range imaging sensors acquire an image of a scene, where in addition to standard intensity information, the range (or distance) is also measured concurrently by each pixel.
A. A. Dorrington +5 more
core +1 more source
Optical coherence tomography in archaeological and conservation science - a new emerging field [PDF]
, 2008 There has been a long tradition of applying biomedical imaging techniques to the examination of historical artefacts, owing to similar demands for non-invasive methods in both fields. Optical Coherence Tomography (OCT) is no exception.
Peric, B. +17 more
core +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Proof of concept of diffuse optical tomography using time-of-flight range imaging cameras
, 2010 Diffuse optical tomography is an optical technique to create 3-dimensional images of the inside of highly scattering material. Research groups around the world have been developing imaging systems using various source-detector arrangements to determine ...
Ahmad Hassan +7 more
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