Results 111 to 120 of about 700,724 (318)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Multiplexing a serial array of tapered optical fibre sensors using coherent optical frequency domain reflectometry [PDF]

, 2012
The use of high spatial resolution optical frequency domain reflectometry (OFDR) to facilitate the multiplexing of a serial array of tapered optical fibre sensors is presented.
Tatam, Ralph P., Chehura, Edmon, James, Stephen W., Jarzebinska, Renata   +3 more
core   +1 more source

Optical Radiation Measurements and Instrumentation

Journal of Investigative Dermatology, 1981
Accurate measurement of optical radiation is required when sources of optical radiation are used in biological research. Such measurement of broad-band noncoherent optical radiations usually must be performed by a highly trained specialist using sophisticated, complex, and expensive instruments.
Andersen, F. Alan, Landry, Robert J.
openaire   +2 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Nonlinear optical characterisation of organic chromophores and aspects of molecular aggregation [PDF]

, 2001
The work presented in this thesis describes an investigation into the properties and behaviour of a new class of nonlinear optical organic chromophores.
Hackman, Nancy-Ann
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Verification of NADH content measurements by portable optical diagnostic system in living brain tissue [PDF]

, 2018
The overall aim of this study was verification of the possibility to register the change of NADH fluorescence in live tissue by a portable diagnostical laser system with fibre optical probe output and excitation by compact semiconductor UV light source ...
Sokolovski, S, Abramov, A, Edik U. Rafailov, Andrey Abramov, Rafailov, E, Abramov, Andrey, Sergei G. Sokolovski, Zherebtsov, E, Angelova, Plamena, Zherebtsov, Evgeny, Angelova, P, Rafailov, Edik U., Sokolovski, Sergei G., Tuchin, Valery V., Evgeny Zherebtsov, Plamena Angelova   +15 more
core   +1 more source

Evaluating the Degradation of WE43 for Implant Applications: Optical and Mechanical Insights

Applied Sciences
In the context of an ageing society, advancements in medicine and biomedical technology are becoming increasingly important. A major goal is to minimise the number of surgical operations.
Janina Siring, Anil Cökelek, Norman Mohnfeld, Hendrik Wester, Bernd-Arno Behrens   +4 more
doaj   +1 more source

Testing of Piezo-Actuated Glass Micro-Membranes by Optical Low-Coherence Reflectometry

Sensors, 2017
In this work, we have applied optical low-coherence reflectometry (OLCR), implemented with infra-red light propagating in fiberoptic paths, to perform static and dynamic analyses on piezo-actuated glass micro-membranes.
Sabina Merlo, Paolo Poma, Eleonora Crisà, Dino Faralli, Marco Soldo   +4 more
doaj   +1 more source