Results 91 to 100 of about 123,133 (293)

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Fano Resonance Thermo-Optic Modulator Based on Double T-Bus Waveguides-Coupled Micro-Ring Resonator

Photonics
For the silicon optical computing chip, the optical convolution unit based on the micro-ring modulator has been demonstrated to have high integration and large computing density.
Hongpeng Li, Lidan Lu, Guang Chen, Shuai Wang, Jianzhen Ou, Lianqing Zhu   +5 more
doaj   +1 more source

Optical Single Sideband Modulator Without Second-Order Sidebands

IEEE Photonics Journal, 2018
An optical single sideband modulator without generating both the −2nd- and +2nd-order sidebands is presented. It is based on a parallel operation of two dual-drive Mach–Zehnder modulators (DDMZMs) where one is operated as a ...
Erwin Hoi Wing Chan, Chongjia Huang, Chirappanath B. Albert   +2 more
doaj   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

A Comparison between Two Heterodyne Light Sources Using Different Electro-Optic Modulators for Optical Temperature Measurements at Visible Wavelengths

Sensors, 2010
In this paper we have successfully demonstrated a z-propagating Zn-indiffused lithium niobate electro-optic modulator used for optical heterodyne interferometry.
Ruey-Ching Twu, Yi-Huan Lee, Hong-Yao Hou   +2 more
doaj   +1 more source

Light ray modulation controls optical system alignment [PDF]

, 1965
Light ray modulator maintains focus in optical system subject to severe thermal gradients, vibration and shock.

core   +1 more source

Attojoule-efficient graphene optical modulators

Applied Optics, 2018
arXiv admin note: text overlap with arXiv:1502.04672 by other ...
Rubab Amin, Zhizhen Ma, Rishi Maiti, Sikandar Khan, Jacob B. Khurgin, Hamed Dalir, Volker J. Sorger   +6 more
openaire   +3 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

A Conceptual Study of Rapidly Reconfigurable and Scalable Optical Convolutional Neural Networks Based on Free-Space Optics Using a Smart Pixel Light Modulator

Computers
The smart-pixel-based optical convolutional neural network was proposed to improve kernel refresh rates in scalable optical convolutional neural networks (CNNs) by replacing the spatial light modulator with a smart pixel light modulator while preserving ...
Young-Gu Ju
doaj   +1 more source

High-Performance Hybrid Silicon and Lithium Niobate Mach-Zehnder Modulators for 100 Gbit/s and Beyond

, 2018
Optical modulators are at the heart of optical communication links. Ideally, they should feature low insertion loss, low drive voltage, large modulation bandwidth, high linearity, compact footprint and low manufacturing cost.
Cai, Xinlun, Chen, Hui, Gao, Shengqian, Guo, Changjian, He, Mingbo, Jian, Jian, Liu, Lin, Liu, Liu, Ren, Yuxuan, Ruan, Ziliang, Sun, Shihao, Wen, Xueqin, Xu, Mengyue, Xu, Yongsheng, Yu, Siyuan, Zhou, Lidan   +15 more
core   +1 more source