Results 71 to 80 of about 123,133 (293)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Dually-mode-locked ND: YAG laser [PDF]

, 1974
Mode-locking is stabilized effectively by conventional loss-modulator and phase-modulator, mode-locking elements placed in laser cavity in optical series with one another.
Osmundson, J., Rowe, E., Santarpia, D.
core   +1 more source

Optical interconnect with densely integrated plasmonic modulator and germanium photodetector arrays [PDF]

, 2016
We demonstrate the first chip-to-chip interconnect utilizing a densely integrated plasmonic Mach-Zehnder modulator array operating at 3 x 10 Gbit/s.
Bauerle, B, Chen, H, Dalton, LR, Elder, DL, Fedoryshyn, Y, Haffner, C, Hafner, C, Heni, W, Hillerkuss, D, Hoessbacher, C, Josten, A, Leuthold, J, Salamin, Y, Van Campenhout, J, Van Thourhout, Dries, Wehrli, S, Zahner, M   +16 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Wideband, high efficiency optical modulator requires less than 10 watts drive power [PDF]

, 1967
Wideband optical modulation system operates with less than 10-watts drive power. It consists of an optical modulator and transistorized driver that combines small cross-section potassium dideuterium phosphate crystals with laser beam-condensing optics ...
Becknell, W. E., Rattman, W. J., Yap, B. K.   +2 more
core   +1 more source

Modulation efficiency of LiNbO₃ waveguide electro-optic intensity modulator operating at high microwave frequency

, 2009
The modulation efficiency, at high-frequency microwave modulation, of a LiNbO3 waveguide electro-optic modulator is shown to be degraded severely, especially when it is used as a frequency translator in a Brillouin-distributed fiber-sensing system.
Liao, Y., Meng, Z., Zhou, H.
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Sol-Gel Material-Enabled Electro-Optic Polymer Modulators

Sensors, 2015
Sol-gels are an important material class, as they provide easy modification of material properties, good processability and are easy to synthesize. In general, an electro-optic (EO) modulator transforms an electrical signal into an optical signal.
Roland Himmelhuber, Robert A. Norwood, Yasufumi Enami, Nasser Peyghambarian   +3 more
doaj   +1 more source

Phase and Amplitude Responses of Narrow-Band Optical Filter Measured by Microwave Network Analyzer [PDF]

, 2006
The phase and amplitude responses of a narrow-band optical filter are measured simultaneously using a microwave network analyzer. The measurement is based on an interferometric arrangement to split light into two paths and then combine them.
Hau-kai Chen, Hsi-cheng Wang, Hsin-chia Lu Member, Keang-po Ho, Senior Member, Student Member   +5 more
core   +3 more sources