Results 81 to 90 of about 8,453,335 (366)

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Anti-resonant acoustic waveguides enabled tailorable Brillouin scattering on chip

Nature Communications
Empowering independent control of optical and acoustic modes and enhancing the photon-phonon interaction, integrated photonics boosts the advancements of on-chip stimulated Brillouin scattering (SBS). However, achieving acoustic waveguides with low loss,
Peng Lei, Mingyu Xu, Yunhui Bai, Zhangyuan Chen, Xiaopeng Xie   +4 more
doaj   +1 more source

All-optical spiking neurosynaptic networks with self-learning capabilities [PDF]

Nature, 2019
Software implementations of brain-inspired computing underlie many important computational tasks, from image processing to speech recognition, artificial intelligence and deep learning applications.
J. Feldmann, N. Youngblood, C. Wright, H. Bhaskaran, W. Pernice   +4 more
semanticscholar   +1 more source

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

FEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori   +15 more
wiley   +1 more source

Improved Power Budget of 112 Gb/s/$\lambda$ Intra-Datacentre Links Using a Split-Carrier Transmitter Architecture

IEEE Photonics Journal, 2019
A split-carrier transmitter is proposed to improve loss budget for short distance 100 G-per-wavelength intra-datacentre links. By applying a low-complexity hardware modification to the transmitter, the proposed architecture reduces transmitter loss ...
Thomas Gerard, Zhixin Liu, M. Sezer Erkilinc, Lidia Galdino, Polina Bayvel, Benn Thomsen, Domanic Lavery   +6 more
doaj   +1 more source

Frequency-insensitive spatiotemporal shaping of single photon in multiuser quantum network

npj Quantum Information, 2023
Exploiting the fundamental features of quantum mechanics, an entanglement-based quantum network offers a promising platform for many dramatic applications such as multi-user cryptography.
Yiwen Huang, Zhantong Qi, Yilin Yang, Yuanhua Li, Yiwei Sun, Yongzhi Tang, Fengchao Ni, Lanting Li, Yuanlin Zheng, Xianfeng Chen   +9 more
doaj   +1 more source

Knockout of the mitoribosome rescue factors Ict1 or Mtrfr is viable in zebrafish but not mice: compensatory mechanisms underlying each factor's loss

FEBS Open Bio, EarlyView.
Mitochondria contain two mitoribosome rescue factors, ICT1 and MTRFR (C12orf65). ICT1 also functions as a mitoribosomal protein in mice and humans, and its loss is lethal. Although Mtrfr knockout mice could not be generated, knockout zebrafish lines for ict1 and mtrfr were established.
Nobukazu Nameki, Chika Tomisawa, Soichiro Hoshino, Hidehiko Shimizu, Masashi Abe, Sho Arai, Kanako Kuwasako, Naoki Asakawa, Yusuke Inoue, Takuro Horii, Izuho Hatada, Masakatsu Watanabe   +11 more
wiley   +1 more source

Profiling the effect of low frequency mechanical vibration on the metabolic and oxidative stress responses of A431 carcinoma

FEBS Open Bio, EarlyView.
20 Hz mechanical vibration induced A431 cancer cells' apoptosis without such effect on other healthy cell lines of L929 and C2C12. Lowered glucose consumption is observed specifically in A431. The expressions of ROS, HMGB1, and HSP1 levels initially increase and subsequently decrease in the cancer cell line, as opposed to L929 and C2C12, which ...
Wresti L. Anggayasti, Chikahiro Imashiro, Takashi Morikura, Shogo Miyata, Akira Funahashi, Kenjiro Takemura   +5 more
wiley   +1 more source

SOON: self-optimizing optical networks with machine learning.

Optics Express, 2018
As optical networks undergo rapid development, the trade-offs among higher network service capability, and increasing operating expense (OPEX) about operations, administration and maintenance (OAM) become telecom operators' key obstacles. Intelligent and
Yongli Zhao, Boyuan Yan, Dongmei Liu, Yongqi He, Dajiang Wang, Jie Zhang   +5 more
semanticscholar   +1 more source

UR‐cycleGAN: Denoising full‐body low‐dose PET images using cycle‐consistent Generative Adversarial Networks

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose This study aims to develop a CycleGAN based denoising model to enhance the quality of low‐dose PET (LDPET) images, making them as close as possible to standard‐dose PET (SDPET) images. Methods Using a Philips Vereos PET/CT system, whole‐body PET images of fluorine‐18 fluorodeoxyglucose (18F‐FDG) were acquired from 37 patients to ...
Yang Liu, ZhiWu Sun, HaoJia Liu
wiley   +1 more source