Results 101 to 110 of about 2,822,034 (303)

Instantaneous modulations in time-varying complex optical potentials

New Journal of Physics, 2017
We study the impact of a spatially homogeneous yet non-stationary dielectric permittivity on the dynamical and spectral properties of light. Our choice of potential is motivated by the interest in ${ \mathcal P }{ \mathcal T }$ -symmetric systems as an ...
Armen G Hayrapetyan, S P Klevansky, Jörg B Götte   +2 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

New class of antisymmetrized optical potentials

Physical Review C, 1984
This paper is mainly concerned with the construction and various properties of a new class of antisymmetric, two-fragment, elastic scattering optical potentials. The construction is based directly on the wave function formulation of $N$-particle collision theories, which are antisymmetrized herein using the method of Adhikari and Gl\"ockle.
Sadhan K. Adhikari, R. Kozack, F.S. Levin   +2 more
openaire   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Measurements of the Beam-Wave Fluctuations over a 142-km Atmospheric Path [PDF]

, 2006
An optical link has been established between the Canary Islands La Palma and Tenerife. A 1064-nm transmitting laser was located on La Palma whereas a BPSK communication receiver and measurement instruments were installed in ESA's OGS on Tenerife.
Perlot, Nicolas, K. Zettl, Knapek, Markus, Zettl, Karl, H. Henniger, Giggenbach, Dirk, D. Giggenbach, Henniger, Hennes, Horwath, Joachim, J. Horwath, N. Perlot, M. Knapek   +11 more
core   +1 more source

Prediction of reaction cross section for p-Cr

EPJ Web of Conferences, 2016
Nuclear matter densities and charge radii for even 46−62Cr isotopes have been calculated using relativistic Hartree-Bogoliubov model based on density-dependent meson-exchange relativistic energy density functional.
Hemalatha M., Maladkar N., Kailas S.
doaj   +1 more source

Probing membrane potential with nonlinear optics

Biophysical Journal, 1993
The nonlinear optical phenomenon of second harmonic generation is shown to have intrinsic sensitivity to the voltage across a biological membrane. Our results demonstrate that this second order nonlinear optical process can be used to monitor membrane voltage with excellent signal to noise and other crucial advantages.
Bouevitch, O., Lewis, A., Pinevsky, I., Wuskell, J.P., Loew, L.M.   +4 more
openaire   +2 more sources

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source