Results 81 to 90 of about 581,869 (300)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Refractionless propagation of discretized light

, 2017
Light refraction, i.e. the bending of the path of a light wave at the interface between two different dielectric media, is ubiquitous in optics. Refraction arises from the different speed of light and is unavoidable in continuous media according to Snell'
Longhi, Stefano
core   +1 more source

Light bullets in optical tandems [PDF]

Optics Letters, 2009
We address the concept of three-dimensional light bullet formation in structures where nonlinearity and dispersion are contributed by different materials, including metamaterials, which are used at their best to create suitable conditions where bullets can form.
Torner Sabata, Lluís, Kartashov, Yaroslav V.   +1 more
openaire   +5 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

PT-symmetry in optics beyond the paraxial approximation

, 2014
The concept of the PT-symmetry, originating from the quantum field theory, has been intensively investigated in optics, stimulated by the similarity between the Schr\"odinger equation and the paraxial wave equation that governs the propagation of light ...
Chen, Xianfeng, Huang, Changming, Kartashov, Yaroslav V., Malomed, Boris A, Ye, Fangwei   +4 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Evolution of the Phase Singularity of an Orbital Angular Momentum Beam with an Astigmatism Phase

Photonics
In this study, we explore the impact of the astigmatism phase on the evolution of the phase singularity of an orbital angular momentum (OAM) beam propagating through free space. The results demonstrate that the high-order phase singularity dispersed into
Chunhao Liang, Cuiling Zheng, Xinru Lian, Qian Chen, Yaru Gao, Jinsong Liu, Yangjian Cai, Jun Zeng   +7 more
doaj   +1 more source

Optical scatter of quantum noise filter cavity optics

, 2015
Optical cavities to filter squeezed light for quantum noise reduction require optics with very low scattering losses. We report on measured light scattering from two super-polished fused silica optics before and after applying highly-reflective ion-beam ...
Amra, Claude, Lequime, Michel, Magaña-Sandoval, Fabian, Smith, Joshua R., Vander-Hyde, Daniel, Zerrad, Myriam   +5 more
core   +3 more sources