Results 61 to 70 of about 134,221 (268)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Evolution of the Phase Singularity of an Orbital Angular Momentum Beam with an Astigmatism Phase

Photonics
In this study, we explore the impact of the astigmatism phase on the evolution of the phase singularity of an orbital angular momentum (OAM) beam propagating through free space. The results demonstrate that the high-order phase singularity dispersed into
Chunhao Liang, Cuiling Zheng, Xinru Lian, Qian Chen, Yaru Gao, Jinsong Liu, Yangjian Cai, Jun Zeng   +7 more
doaj   +1 more source

Enhanced neuroimaging with a calcium sensor in ex-vivo Drosophila melanogaster brains using closed-loop adaptive optics light-sheet fluorescence microscopy. [PDF]

J Biomed Opt, 2023
Hubert A, Farkouh G, Harms F, Veilly C, Imperato S, Mercier M, Loriette V, Rouyer F, Fragola A.   +8 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Optical Communication Performance of Cylindrical Vector Partially Coherent Laguerre–Gaussian Beams in Atmospheric Turbulence

Photonics
The optical communication performance of cylindrical vector partially coherent Laguerre–Gaussian (PCLG) beams in different atmospheric turbulence models are investigated.
Meng Liu, Linxuan Yao, Yaru Gao, Hui Zhang, Yangsheng Yuan, Bohan Guo, Huimin Shi   +6 more
doaj   +1 more source

Spin-Independent Plasmonic Lens

Nanoscale Research Letters, 2019
For the semicircular plasmonic lens, the spiral phase is the origin of the spin-dependent surface plasmon polariton (SPP) focusing. By counterbalancing the spin-dependent spiral phase with another spiral phase or Pancharatnam-Berry phase, we realized the
Guoqun Li, Yuqing Sun, Sen Wang
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Full polarization and high coherence control of thermal emissions via saddle-band dispersion engineering

Nature Communications
Photonic engineering in metasurfaces has enabled unprecedented control over thermal emissions in recent years. Here, we present a design strategy that achieves full and simultaneous control over both polarization and coherence of thermal emission across ...
Kaili Sun, Guangdong Wang, Wenyu Li, Yinghan Wang, Yangjian Cai, Lujun Huang, Andrea Alù, Zhanghua Han   +7 more
doaj   +1 more source

A Novel Joint Denoising Strategy for Coherent Doppler Wind Lidar Signals

Remote Sensing
Coherent Doppler Wind Lidar (CDWL) is an effective tool for measuring the atmospheric wind field. However, CDWL is affected by various noises, which can reduce the usable value of the received echo signal.
Yuefeng Zhao, Wenkai Song, Nannan Hu, Xue Zhou, Jiankang Luo, Jinrun Huang, Qianqian Tao   +6 more
doaj   +1 more source